Bio X4

Updated May 16, 2019.
Published Aug 22, 2016.
Dr. Krystal Crawford, ND, MS
Medically reviewed by Dr. Krystal Crawford, ND, MS, written by Jane Weston.

Bio X4 contains 4 blended compounds that work together in order to attack weight loss issues. However, we don’t see how or why Bio X4 could help you lose weight as there is no evidence for probiotics and digestive enzyme supplements aiding weight loss. Added to this, is the lack of testimonials on the official site and lack of clinical studies.


  • Comes with a 90-day money-back guarantee
  • Available from a reputable company – no associated scam issues


  • No evidence that taking probiotics and digestive enzymes will lead to weight loss
  • May cause gastrointestinal side effects
  • Lack of positive testimonials
Bio X4
Bio X4 is a 4-in-1 weight management probiotic-created by Nucific, who have a range of products that they claim are backed by science to help us operate at our best.

The company says that they stick to four fundamental principles, which are applied to all their products. They claim only to use potent ingredients that are supported by clinical studies; the products are quality tested to ensure potency and purity. They are earth friendly, by using renewable energy and recyclable materials, and, lastly, all their products are made in California. Can Bio X4 live up to the hype?

Bio X4 Overview

What you need to know about Bio X4

After going over all the information we have collected, it would seem that Nucific Bio X4 may help some people improve their digestive health, but there is NO accepted evidence that it will help with weight loss.

If your digestive system is functioning normally, there seems to be no reason to take this supplement.

If you do have digestive problems, you should visit your doctor rather than trust a rather expensive and unproven OTC supplement. Although the fact that the company is run by trained medical professionals is encouraging, unfortunately, there is insufficient evidence to suggest that this supplement will be safe.

What are the side effects of Bio X4?

We feel that probiotics need a further clinical investigation to prove all the claims that have been made here and eliminate concerns about contamination and safety issues.

There is mounting evidence that certain Lactobacillus probiotics can actually cause weight gain:

Different Lactobacillus species are associated with different effects on weight change that are host-specific. Further studies are needed to clarify the role of Lactobacillus species in the human energy harvest and weight regulation. Attention should be drawn to the potential effects of commonly marketed lactobacillus-containing probiotics on weight gain. Source

We like green tea extract for weight loss, as it is included in a lot of products nowadays and has been proven to help with weight loss goals.

How much does Bio X4 cost?

One bottle (30-day supply) costs $49.00. Nucific seems to be a reputable company, and we love that they offer a guarantee on their products, something a lot of other companies could learn from.

What we weren’t impressed with is the lack of testimonials on the official site and lack of clinical studies. How many people have actually tried this product and found it to work in the way they state?

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Bio X4 Key Features

Bio X4 Key Points

  • Nucific is based in California – full contact details are provided
  • Each bottle contains 90 capsules or one month’s supply
  • Available to buy in a 6-month supply

Trying to lose weight can be a tough journey, but there are some techniques that can make it easier, such as eating a healthy diet and exercising regularly. Sometimes a dietary supplement can make all the difference in the world, and Bio X4 says that it is designed to help:

  • Control hunger cravings
  • Boost the metabolism and burn fat
  • Give you more energy and nutrients from the food you eat
  • Make you feel more confident without gas and bloating after eating

Bio X4 contains 4 blended compounds that work together in order to attack weight loss issues. This is perfect for people who would like a supplement that has no lactose, no fillers, uses 100% pure ingredients and uses vegetarian capsules. What’s not to like?

The principle ingredient is the probiotic blend, which is said to contain 4 billion healthy bacteria per capsule, which is a heck of a lot, and is composed of a Lactobacillus blend and a Bifidobacterium blend. Probiotics are important for our health, and our bodies could not do without these colonies of the live bacteria and yeasts found naturally in our bodies. Lactobacillus is a bacteria that is naturally present in the stomach, which produces vitamin K and Lactase (which breaks down Lactose, the sugars in milk products). Bifidobacterium is a type of bacteria present in the colon flora in animals, as well as in the gastrointestinal tract in humans.

Since the mid-1990s, probiotics and supplements containing them have been advertised as a way to benefit the digestion system and help with IBS, eczema, and oral health. However, the probiotic supplements and foods do not have any medical backing behind them, which could be a cause for concern.

As well as a probiotic blend, Bio X4 also contains a digestive enzyme blend. Digestive enzymes are present in the body naturally and break down food molecules so that they can be absorbed by the body, and taking a supplement including them is said to improve digestion. Bio X4 also contains green tea extract, which is well known for its beneficial effects on health and weight loss. There is some evidence that suggests green tea can increase the speed of the metabolism, making you lose weight more effectively.

The final ingredient in Bio X4 is Caralluma Fimbriata, a cactus extract that may help cause feelings of satiety to prevent overeating and food cravings.

Bio X4 Concerns:

  • You may not notice any effects from this supplement
  • No independent customer feedback
  • Not safe for everyone. May introduce infection if you have a weakened immune system. Could be dangerous if you don’t realize

What does Bio X4 claim to do?

The manufacturers claim that with Bio X4 you can:

Take control of your appetite again, enhance your metabolism & digestion, and feel better than ever.

The way that each ingredient blend works is explained:

  • Digestive enzymes that help get you the maximum amount of nutrients out of everything you eat.
  • 12 Billion Colony-Forming Units (CFUs) of probiotics to rebalance your digestive tract with healthy gut bacteria.
  • The appetite suppressing power of Caralluma Fimbriata.
  • EGCG, sourced from green tea extract, to help support your metabolism.

To utilize Bio X4 to the best of its ability you have to take one capsule with each meal. When taken three times daily, an individual receives 12 billion CFU’s. More may be taken as needed. Supplementing each meal with digestive help that assists in processing your food and extracting the maximum amount of nutrients gives your body the tools it requires to operate at its peak level of performance.

Does Bio X4 work?

When we look back over the facts, we don’t see how or why Bio X4 could help you lose weight, as there is no evidence for probiotics and digestive enzyme supplements aiding weight loss. While the green tea and Caralluma Fimbriata look promising, the ingredient amounts seem inadequate.

Probiotics for weight loss remain largely untrialled and untested. This form of medical science is in the early stages, and nobody knows for sure if probiotics are generally good to take in supplement form. In addition, they are not suitable for everyone as they come with the risk of introducing bacteria into your system.

Not only are the weight loss claims unproven, but the claims about digestive enzymes are also unproven. We cannot see Nucific Bio X4 doing much for your health or your weight loss.

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Bio X4 Ingredients

Nucific Bio X4 is a probiotic supplement that looks to address digestive issues as well as help you lose weight. Serving size is equal to one capsule.

Probiotic blend (4 billion):

  • Lactobacillus acidophilus blend (L. acidophilus, L. rhamnosus, L. planterum): Lactobacillus acidophilus is present in different parts of the body including intestines, mouth, and vagina where it helps protect against harmful bacteria and infection. It may help to protect against coronary heart disease. It may help improve lipid metabolism. However, it does require further evidence to prove these claims. Source
  • Bifidobacterium blend (B. lactis, B. animalis): This probiotic bacterium is found in some dairy products (including breast milk), and may help digestive disorders such as irritable bowel syndrome.

Digestive enzyme blend (88mg):

  • Amylase: This enzyme is present in our saliva and helps us digest carbs, such as rice and potatoes. Some ingredients, such as Kelp and Garcinia Cambogia, prevent this digestive process and some people believe that doing this stops carbs from being absorbed by the body and turning to fat. Other people believe that digestive enzyme supplements help the body’s digestion and help weight loss.
  • Bromelain: This natural enzyme is found in pineapple. According to clinical research, it may be effective in helping to reduce pain and inflammation.
  • Lipase: This is a digestive enzyme, which is made in the pancreas and is lacking in some people who suffer from medical conditions, such as celiac or Crohn’s disease. Lipase breaks down, transports fats, and is essential to the digestive process. It may help with digestive issues such as indigestion and gas. Source

Weight Management blend:

  • Green Tea (100mg): Clinical research has found that green tea has proven health benefits, and the antioxidants (EGCG and polyphenols) found to have anti-obesity and fat burning properties because of the effects upon the metabolism. Contains caffeine. Source

Craving control blend (166mg):

  • Caralluma Fimbriata: Promising although unproven ingredient for weight loss that may reduce appetite. We covered this native Indian succulent plant in a previous investigation and were impressed. However, it requires further evidence because testing has been very limited. Source

Bio X4 Side Effects

Everybody is different when it comes to supplements and the way he or she may react to them. Some are right as rain, and others feel side effects within moments of ingesting a product. With Bio X4 healthy people are unlikely to experience serious side effects, but the same cannot be said for those with underlying health conditions or a weakened immune system.

Bio X4 could cause the following side effects:

  • Intestinal gas
  • Bloating
  • Abdominal pains/cramps
  • Nausea
  • Diarrhea
  • Painful urination
  • Joint pain

If you are particularly sensitive to caffeine, which is present in green tea, you could experience the following:

  • Jitteriness
  • Sleep disturbances
  • Headaches
Caution: Not suitable for individuals under 18. Avoid if you are pregnant or breastfeeding. Ask your doctor before taking this supplement. Probiotics will not be suitable if you have a weakened immune system or certain medical conditions as it may introduce bacteria and infection into your system. This supplement may cause drug interactions so speak to your doctor if you are taking prescription medication.

Bio X4 Customer Feedback

As far as user reviews go we have been unable to locate any reviews on the official site, but we did locate some on Amazon, and the findings were interesting. Here are a few of them:

I tried one whole bottle and saw no results at all. No weight loss, no change in digestion, no change in appetite. Only benefit was it encouraged me to drink more water! I purchased directly through Bio-X4 which cost much less than on Amazon. Scam! Wish I could show no stars.

I bought the Bio-x4 from the company’s website – Nucific. I took it diligently for about 3 weeks. I did not experience any positive effects, e.g., of probiotics. However, my sleep became more restless, and I started experiencing some water retention. I’m returning the product back to the company and hope to receive my money back. Don’t waste your time and money on this product!

This company seems strange and perhaps shady. I bought Bio X4 because it sounded all natural; I thought even if I didn’t lose the weight I wanted to lose, the probiotics and green tea extract would still give me benefits. I bought several bottles because every time I went to check out a new, “better” deal would pop up. That should have been a red flag. As someone else already noted, the Google reviews also seem stacked in Nucific’s favor. All of the results are favorable to Nucific, but all are on web pages completely unfamiliar to me. When I ordered the product I thought it was because the product was so new, but months later, the Google results are still like that. I ended up with heartburn that I believe is related to probiotics (I admittedly could be wrong about this but have heard some people get heartburn from certain types of probiotics), so I tried to return the bottles I had not opened. Unfortunately the 90-day grace period was over, so I have lost significant money on my Nucific purchase with nothing noticeably gained on my end. The e-mails from the company are also strange, as are the recipes. Hard to explain but something seems fake or “off” about this company. I would not buy their products again.

Going by these reviews, it seems like Bio X4 does not help with weight loss and it is making people doubt the company.

Bio X4 Money-Back Guarantee

When it comes to important details, we feel that one of the most important is that a product must have a guarantee, so the user feels safe knowing that they won’t lose out if the product doesn’t work in the way they want it to. Nobody likes to be disappointed and realize they lost a lot of money for no reason.

On the site, Nucific offers a full 90-day money-back guarantee. Here is what they say:

If you’re not 110% satisfied by the results, send back your order within 90 days for a full refund – no questions asked. You will be absolutely amazed at just how quickly your body can change. See the results for yourself…

Unfortunately, it doesn’t specify whether this applies to opened and unopened bottles, so we would suggest contacting them beforehand for confirmation. To claim a refund, you need to call 888-679-5520 Monday – Friday from 6am to 8pm, as well as weekends 5am to 5pm.

Where To Buy Bio X4

Nucific Bio X4 is only available from the official site where there are 3 options available for you to choose from.

  • One bottle (30-day supply) costs $49.00
  • Three bottles (90-day supply) costs $129.00
  • Six bottles (180-day supply) costs $240.00

There is free shipping on all orders over $50.

Watchdog Verdict

While Bio X4 is marketed very slickly, especially with the video marketing featuring Dr. Amy Lee, the jury is still out on probiotics and weight loss. Is it worth taking something that some evidence shows may cause weight gain? We feel that the best bet if you want to experiment, is to consume a natural yoghurt every now and then.

For now, we have no other choice but to reject this supplement. We do not recommend Bio X4 to our readers.

Bio X4 Frequently Asked Questions (FAQ)

What is Bio X4?

Bio X4 is a 4-in-1 probiotic supplement that claims to help you lose weight, to help you take control of your cravings and to enhance your metabolism and digestion.

What are the side effects of Bio X4?

Bio X4 can cause gas, bloating, abdominal pain, nausea, diarrhea, joint pain, jitteriness, and headaches. If taken too close to bedtime, it may cause insomnia.

What are the ingredients in Bio X4?

Bio X4 contains four proprietary blends known as Probiotic Blend (lactobacillus acidophilus and bifidobacterium), Digestive Enzyme Blend (amylase, bromelain, and lipase), Weight Management Blend (green tea extract), and Craving Control Blend (Caralluma fimbriata).

Does Bio X4 work?

There is no evidence that probiotics could help with weight loss; the studies and clinical trials are scarce and inconclusive.

How much does Bio X4 cost?

A 30-day supply costs $49.00, a 90-day supply is $129.00, and a 180-day supply is $240.00.

Who makes Bio X4?

Bio X4 is manufactured by Nucific, a company based in California.

How do I take Bio X4?

Take one capsule with a meal, three times a day.

Can I take Bio X4 if I have a health condition?

Avoid if you are pregnant or breastfeeding. Probiotics are not recommended if you have a weakened immune system or certain medical conditions; it is recommended to see a doctor prior to the treatment.

Does Bio X4 have a money-back guarantee?

There is a 90-day money-back guarantee.

How long has Bio X4 been around?

The website only says that Bio X4 is ‘brand new’, but does not precise when it has been put on the market.

Where can I buy Bio X4?

Bio X4 can be bought online from the official Nucific website.

Can I buy Bio X4 in stores?

No, Bio X4 is only available online from the official website.

How do I contact Bio X4 customer service?

You can contact Nucific customer service seven days a week via email or phone with the details they provide on their website. It is important to remember that their business hours are Pacific Time.

Are there any Bio X4 coupons?

At this time, there are no Bio X4 coupons.

Are there any free samples of Bio X4?

Nucific does not offer free samples for Bio X4.

How does Bio X4 compare to Phentaslim?

Criteria Bio X4 Comparison Phentaslim comparison
Clinically Proven Ingredients
Side Effect Free
Positive Customer Reviews
24/7 Support
Money-back Guarantee

Disclaimer: Our reviews and investigations are based on extensive research from the information publicly available to us and consumers at the time of first publishing the post. Information is based on our personal opinion and whilst we endeavour to ensure information is up-to-date, manufacturers do from time to time change their products and future research may disagree with our findings. If you feel any of the information is inaccurate, please contact us and we will review the information provided.

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228 comments on 'Bio X4'

  1. This product has done everything it said it would. My stomach is not distended from bloating anymore. I can eat a salty meal and I don’t gain 3 pounds like I did before, and I poop once a day, which I haven’t for years and feel like it’s everything I ate the day before. My skin doesn’t look cellulitey from water retention, and I’ve lost 8 pounds without doing anything different. I didn’t buy it to lose weight, though. I bought this pill because I would eat a meal, and have a ball of bloating in my stomach. The bloating was ridiculous. I was creeping up the scale despite eating only two meals a day and cutting essentially all sweets and carbs and exercising. The candida inundation in my digestive system was acting like a sponge. This pill is undoing years of imbalance. Try it if you haven’t had a good poop in ages. I promise you, it will change your life.

  2. I agree with the Amy Lee sales pitch. It applies to most Americans, but I learned about our food product ingredients for sugar addiction many years ago. I do not buy anything without knowing all the ingredients, and recognize corporation advertisements are lying!
    I have always been below normal weight, and it has not changed 5 pounds in 50 years. I DO NOT EAT JUNK! (The most dangerous addictive drug in the world it SUGAR.)

  3. This product improved my digestive system, for years I been suffered with constipation for far as my digestive system improved tremendously … However I am having some joint pain, but the good news I lost 7 lbs in one month and my energy level are great, my fatigue are gone.
    I made a few changes in my life.. I walk a least 45 minutes everyday, trying to eat healthy. I cut a lot of the Sugar product, eating more vegetable, natural fruit eat more at home
    I hope this is helpful

  4. Got two months worth, of more potent ingredients, from quality suppliers for nearly HALF of the discount price of $49/month of Bio X4! Check out the Swanson Health Website.
    Healthy Origins Natural Teavigo – 150 mg 60 Caps $15.53 (I take 1 per day)
    Bio Nutrition Caralluma – 1,000 mg 60 Veg Caps $11.54 (I take 1 per day)
    NOW Foods Clinical GI Probiotic 50+ Formula – 20 Billion CFU 60 Veg Caps $18.59 (I take 1 per day)
    Swanson Premium Pancreatin 4X – Triple Strength – 750 mg 300 Tabs $14.99 (I take 3 per day)
    Swanson Premium Bromelain – 200mg 200 Tabs $8.38 (I take 3 per day)
    Total: $58.67 for TWO months, Nucific website shows $49.00 (discount) for one month…

  5. I took one pill the first day, no problem.the second day I took 2,the same night I could not sleep I had a very strong burning sensation in my stomach and my esophagus. I stop taking the pills but the burning sensation is still there lingering. Is anyone else had the same problem. I guess I am going to return it to the company.

  6. This stuff really improved my digestive system, unbelievably awesome far as my digestive system improved tremendously … However I am having some major pain for the last two nights so bad I can’t get any sleep . I don’t know if it is side effects from Bio X4 ? I do know I have never felt this kind of pain in my lower back around the Kidney area both sides.
    I really hope it’s not from this product because it really work for my digestive system.

  7. Thank you. I was considering the bio-x4 product. Instead I am opting for a physical check up. You just saved me $150.00. So glad I found this website. Thanks again.

  8. It’s amazing! I was a bit sceptical but within a few days my digestive system was 100% better, my energy has increased and I have lost 11lbs in 2 weeks.

  9. Dr. Amy Lee has a proven medical history and training. I will trust her product that comes in a GLASS jar over that plastic junk any day.

    Any major change to the body will have effects which will be unique from one person to the next.

    Dr. Lee did say talk to your physician first.

  10. This product has worked very well for myself. I took it only once, before every meal and I lost 29 lbs. I ordered the product a second time just to maintain my weight loss. I know only take 1-2 capsules per day. No real problems , such as joint pain or stomach problems. I must add that I did some exercise , not a lot, and I ate healthier foods. I would recommend this product.

  11. X4 – my first dose 3 pills one at each meal.I woke up during the night feeling uncomfortable. My head felt heavy and my body felt weird including my lower back. My legs and feet felt heavy and numb. I got out of bed and tried to walk. I have been up for 3 hours with my legs and feet feeling weak. I have to wait until Monday to see a doctor. I went on line it said it does have side effects, including joints. I have had problems with my joints in the past.I just want to up date you on what I am sure my problems comes from this product.

    1. Could be the Cellulose capsules. I get arthritis when I eat any type of cellulose and with the research I have done it turns out it’s not a vegetable capsule, they are just allowed to call it that. It really is wood pulp and I can’t even eat shredded cheese, which has it or else I have to wear a brace on my wrists.

  12. I have really lost over 10-15lbs All my friends are asking me what am I doing it really does work have been taken it for about 1mnth and half.

    1. I have received Nucific and have been taking for a week. I noticed painful urination immediately. What causes that from the extract and how is it treated?

    2. I can’t find the source now, but urinary tract pain was on a list of possible side effects of either bioX4 or one of it’s ingredients. I had this pain also, yesterday after the first two doses. I’m monitoring for side effects to decide whether to return or not. Most of the side effects listed online are GI – bloating, gas, stomach upset/pain, which may settle down after a week or so. I read some worrisome info on Wikipedia, EGCG is a catechin, which may have an immune response: “Depending on dose consumed, catechins and their metabolites can bind to red blood cells and possibly induce release of autoantibodies, resulting in haemolytic anaemia and renal failure.[53] This resulted in the withdrawal of the catechin-containing drug Catergen, used to treat viral hepatitis, from the European market in 1985.” Kidney failure isn’t something we’d want to chance, but it must be rare, or we’d hear more about it and ECGC would be taken off the market here. Also under catechins: “Main hazards: Mutagenic for mammalian somatic cells, mutagenic for bacteria and yeast.” The definition of mutagenic:capable of inducing mutation or increasing its rate. Doesn’t sound good, but I’m not a doctor or chemist, so take all of this with a grain of salt. On the plus side, catechins are antioxidants, which we need to destroy free radicals and thus reduce cancer risk. Moderation is good. Hope this is helpful.

  13. I do not recommend Bio.X4. I went to emergency room because of it. It caused horrible lower abdominal pain, and cost me far more paying hospital bills. It seems that it does not work with everyone, if it works at all. Certainly I did not loose one pound, it did not help with anything they claimed that it does help. I wish I can get a refund for it so expensive

  14. I tried Bio X4 for 30 days. I am in the process of trying to get a refund. I suffered with extreme constipation and DID NOT loose any weight. I gained weight!!! Very disappointed and feel that the video on line is deceiving.

    1. If you were constipated, it has nothing to do with enzymes, probiotic or green tea. You probably are dehydrated and not eating enough fats. The ingrediaents in biox4 are very basic and can be bought individually. Digestive enzymes and probuotics are recommended by all nutritionists. Weight gain is probably from stool build up and you probably didnt heed a good diet. Your commments show you are uneducated in nutrituon. See your doctor. He will recommend all the same ingredients in Bio x4 for good for health. You will NOT ever lose weight if your gut is unhealthy. Being constipated says your gut is unhealthy.

    2. you were very rude in your reply and I have read the later comments and others seem to have had the same response from the Bio x4. Did you try the product yourself that would leave you to tell this person that they didn’t feel that way because of the supplement?

  15. Though I can appreciate this website taking the time to “evaluate’ products, the issue for me is lack of information balance in your product promotion of Phentaslim over Bio X4. Both products contains essentially the same ingredients as. So how is it that you can make the claim that Phentaslim has no side effects and Bio X4 does, and how Phentaslim has clinically proven ingredients when Bio X4 doesn’t when Bio X4 has the same ingredients as Phentaslim? Additionally, by virtue of the fact the both products contain the same ingredients inclusive of lactobacillus, the claim of “NO accepted evidence that it will help with weight loss” would therefore be the same for Phentaslim.

  16. I have IBS with constipation will this help with the effects of IBS – regular pain in my left side, everything I eat either goes straight through me or causes constipation. I was told I should take BIO-X4.

  17. DO NOT deal with this company, they are crooks going after your money. They sent me the product even though I requested the order to be cancelled! You can see from the ordering process they are deceptive, trying to trick you into buying more. You never see a order confirmation to make changes before the final order goes through! Customer service will not resolve your problems. I have dealt with a great deal of different companies, but NONE of them is anything like Nucific. The owner is a doctor named Amy Lee from Hong Kong. What a disgrace she is! she should change her name to Amy Lie!

    1. Hi, Angel, I had the same experience with them. I tried to get my money back but they told me they never received the product I sent to them, I think it is a scam also. I felt terrible after using BioX.4


  18. Are these facts on this product accurate or true? How can I trust that what you are saying is true. Why does this product create those side effects and why does the Bio x4 website claim that there is no side effects, but this website is giving these side effects? Also you do not take with your meal, you take it 30 minutes before eating so that you give it time to break down into your digestive system so it can properly work. How did you conclude to take it with your meal? Last question. Those reviews, where can I find those reviews from people? The actual reviews that you posted on this site.

  19. Just using google i found at least 3 double blind plecebo studies showing that the enzymes help with weight loss and pro biotics help with digestion which in turn helps with weight loss. I think you should do some research before you tell people there is no proof of something working. Shame.

  20. Just watched the video and was impressed, but I’m obedient to my discernment and decided to check. Think I will pass on the Bio X4.

  21. I haven’t noticed any weigh-loss, but I do have painful urination and extreme joint pain. I have been to my doctor for the UTI and taken antibiotics. While on the antibiotics, I stopped taking Bio-X4 while on medication, and the problem cleared up. When I finished the antibiotic, I resumed the Bio-x4 and the pain returned. Also, the strongest leg cramps I have ever experienced happened, and I have tremendous pain in my right shoulder, so much so that my doctor thought I had torn the rotator cuff. I cannot recommend this product to anyone.

  22. I am trying to return my bottles, I to have not lost any weight in fact I put on weight and was not very happy !!!! I am looking to get my money back.This product is not what I had hoped it would be, and I should have know better than to try it.

    1. I also have found weight gain and am really upset by this! I’ve requested a refund for my purchase as well. Definitely didn’t help with weight loss and did the opposite. I’m a runner – am training for a marathon – running 5-10 miles a day 3x a week right now – and I’m GAINING WEIGHT? Something very wrong with this picture. Don’t waste your money on this product.

  23. I watched the Nucific video this morning with Dr. Lee. I was impressed and almost yielded to temptation but did not!!! I decided to do some checking and I am so glad that I came across your website. It actually saved me $130.00 that I was seriously thinking about spending on these so called healthy pills from Dr. Lee. If they did all that they say, it would be worth it but I just cannot afford to take a chance on something that won’t help me. I was looking for something that would help me to feel better, not necessarily for weight loss. Yes, I could certainly afford to lose a few pounds but that isn’t what I wanted in these supplements. I wanted to feel more healthy and energetic. I have severe pain drug induced constipation and I was hoping that just maybe these pills would help that situation. But now I have learned that these supplements could help cause constipation, gas, and bloating of which I have enough of the way I am.

    Thank you for telling us about Nucific. Maybe when they have a few thousand testimonials saying that it really helps I will reconsider my purchase.

    Thank you for your research,

    Joanie from NW Indiana USA

    1. Try taking magnesium for pain med induced constipation. I take 400 mg daily and will take a second 400 mg if I have eaten things I know will encourage constipation (like cheese, chocolate, etc.). You may have foods you know cause you problems. Also DSS helps without giving diarrhea. Common item at drug store.

      Good luck.

    2. Hi Joanie, I read your review because I was doing my due diligence to decide if I should try the Bio X4. I noticed that you mentioned that you have bad constipation, I used to suffer with that also but I now use Poop Doc formula 1, which I have been using for 2 years and It is a miracle worker. Google Poop Doc and see for yourself. This product is phenomenal. I’m only passing this info on to you because of my past experiences with constipation and I was blessed to find this. Just passing it forward to help another human being. I gain nothing from it other then helping others. If you decide to check them out ask for Scott the owner of Poop Doc, a down to earth and very knowledgeable person who personally talks to his customers. Good luck with feeling better. Frank L from NY

    3. Dear Joanie,
      I’m so sorry to hear that your suffering from Pain Medicine induces constipation. I too have suffered greatly from that. Please, if you can, start weaning yourself off of the medicine. I know you don’t know me, but I have suffered from pain for over 20 years and have taken medicine, including; Vicodin, Norco, and lastly Tramadol for about 13 years. I have been weaning myself off of the medicine for about a year now and although I’m still in pain, the medicine has it’s own side effects you should seriously know about. I came on this site because when your in pain your first thought is quality of life. Mine is limited. Now, I not only suffer from the pain I have had for such a long time but now I suffer from pain induced from the medicine. I have never been effected mentally from the medicine accept about 5 years ago the left side of my head went numb but it went away. Now…after having setbacks physically, I had to take a bit more medicine than normal but not the full monthly prescription. I was still taking less but now I have had to completely quit. you see, after all these years the medicine started making my right thigh go numb. Now it is numb all the time and although it was a fairly small area on the top of my thigh, it has reached down the side to the back and is extremely painful because now it has a serious burn feeling. I have had to literally pull my pants away from my leg to stop the pain I had from just contact with anything rubbing against my thigh.
      I don’t plan on taking this Bio-x4 but your note moved me because I pray that whoever reads this will stop taking pain medicine. The side effects from my pain medicine has been worse than my daily pain and that says a lot. God Bless you and I hope you can find what you need. Take care.

    4. Joanie, I forgot to tell you this too. Please drink as much water as you can. I drink at least 8 to 10 glasses a day….still! I have had to drink water all through the night because the medicine for pain dehydrates you substantially and will also effect the inside of your stomach and your intestines. Don’t be surprised if you end up with tears on your anal wall. If you have bleeding don’t be surprised if the doctor tells you that it’s internal too. I’m sincerely not trying to grose you out but I have sincerely suffered because the doctor’s don’t always tell you the additional side effects because they don’t know! You have to be, everyone has to be they’re own advocate when they go to the doctor’s. Even when I haven’t taken medicine for a month I’m still dehydrated. I have lost 15 lbs by making small changes and my overall health has improved a bit with the changes. Take baby steps and sincerely look for ways to help yourself feel better. I really know, really know, what to do to improve my health. Knowing it and doing it are two completely different things. Take care.

    5. Hi Joannie and other repliers to her, I was taking pain relief after a hip replacement which caused severe constipation. I was then told to take Movicol and Sennacot to address this and after no effect, requested 2 enemas. None of the above worked as well as the advice of my New Zealand friend. She said eat kiwi fruit with their skins on! What a miracle! I ate two each day for 48 hours and the results were fantastic. After this I ate just one a day as two felt too strong, until I came off the pain killers. I still eat them with the skin on now if I get constipated or occasionally without if I have no digestive problems. Sounds horrible? Just slice them and you don’t really notice the hairy skin! What a pity every doctor isn’t aware of this. Think of how much money we could save and more importantly, you’re eating a natural food, not taking another drug. I don’t know if this works for everyone but lots of people in NZ use this method. Try it and see.

  24. I took Bio X-4 for 2 months. It didn’t work for me, even with other lifestyle changes. I didn’t lose any weight, and suffered from gas and constipation. I rated the product poorly when they sent me a survey, and promptly received a phone call urging me to be patient and persist. I saw no point in carrying on, and returned the remaining bottles. To my surprise, despite their much-touted total satisfaction guarantee, I only received credit for the return, not the entire order. So if you order 3 months’ supply, and persist as recommended, you won’t get any refund… I entered a “disputed charge” claim with my credit card company, and received a full refund from Nucific. But in their email to me Nucific said “Our apologies for any miscommunication in regards to our return policy, we refund for the bottles returned to us. But we are willing to make an exception.” The bottom line is: don’t trust their warranty, and be prepared to make a fuss.

  25. I’ve taken BIO-X4 for just over a week and have a terrible tummy ache today. I also have put a little weight on (started at 10 stone 5 pounds and am now 10 stone 6, which isn’t much, but is going the wrong way!!!). I’ve got three months supply, so will take the lot in the hope that everything improves (mostly because it was a lot of money), but I doubt I’ll buy anymore…

  26. Bio x-4 didn’t work for me. I took it for the month w/exercise (21 mils. per wk on a bike) & I gained 5 lbs. To be fair they reimbursed me. Besides I think this is a ad for Phentaslim!

    1. Probiotics are not a quick fix. Depending on your health history and if you been on antibiotics,taken over the counter medications like Tylenol and Zyrtec, eat GMO and processed foods, your body needs time to heal. 30 days is really not suffice. If you carried the excess weight for more than 30 days, your body needs time to adjust. If you gained weight, it’s a sign that your body is going through the changes and staying consistent with the probiotics, the weight will come off. I’ve been on a probiotic for three years and seen a huge improvement in my health. Hope this helps.

    2. Very curious for those who’ve seen weight loss and weight gain. How much did you weigh when you started?

  27. Looks like a site to promote your own product. Poor digestion is the beginning of all chronic disease. Supporting the digestion should be the 1st step in all programs for wellness, especially weight management.

  28. Reducing weight gain is through a balanced diet, exercise, eating 3 meals a day and 7-8 hours sleep. This includes reduction of refined sugar, products high in sugar, including soft drinks. I don’t use OTC supplements other than multivitamins and vitamin D3. I quit smoking and continue my regime that I started in early 2014.

    I will be 68 in July, my energy level has increased. While moderation of beer, wine and liquor is now reduced by 50% since I no longer smoke. This is about personal motiviation and common sense. If I can do it. Anyone can, it’s about discipline with health being the number 1 priority.

  29. I’m almost halfway through my second bottle and have actually gained about 4 pounds! The first couple weeks I had some stomach pain and diarrhea. Now the past couple weeks I am constipated, feel bloated and my stomach looks bigger. Big waste of money! I should’ve known better.

    1. Very curious for those who’ve seen weight loss and weight gain. How much did you weigh when you started?

  30. I have lost over 40 pounds. I look great, have more energy, my stomach pain from irritable bowel is gone, and my mood has even improved! Plus I don’t have to exercise if I don’t want to! This is a great product!

    1. Very curious for those who’ve seen weight loss and weight gain. How much did you weigh when you started?

  31. I have taken BIOx4 now for 4 months. I have lost 34 lbs. with just a slight increase in exercise. I do have more energy and don’t eat near as much as I use to. So far I believe the product is great.

    1. Very curious for those who’ve seen weight loss and weight gain. How much did you weigh when you started?

  32. Hi,I found the BIOX4 presentation very interesting as she seemed to be able to give very good medical reasons for each & every ingredient. However, I’m not convinced it would work & after reading some of the reviews on here I feel even less convinced that it would work. What I would like to know though, is whether I would have been able to use BIOX4 because I am on Warfarin for life as a result of pulmonary emboli. 2 attacks which landed me in A & E twice in the space of a year. I’m not going to buy it as I can’t afford to spare £40 per month; I only just get by as it is but I would like to know if I could have taken it? I would also like to know whether I can safely take Phentaslim? A pharmacist told me that ANYthing I take now will negatively affect my INR so I have to be careful even when it comes to something as innocent sounding as vitamins! So I would every much appreciate your opinion on this?
    Many thanks,
    Rose @~~>~~>~~> (that’s my emoticon for a rose:)

  33. So I have ordered Bio X4 for a one month supply. So far the product has helped me in many ways. I have more energy, my belly is smaller, and I am regular. For those of you chasing weight loss, I ask you to take a different approach. Your goal should not be weight loss, but should be a better body of health. If you gain some weight that is not necessarily a bad thing. You gain weight because you gain some kind of mass. It doesn’t automatically mean your fatter. You could have gained muscle or internal tissue due to a healthier body. For instance a healed stomachlining can allow your body to repair your stomach tissue adding more mass that was not previously there. I also suggest you use the supplement as instructed. Taking the supplement by itself does not help you. You should be taking with your meal. Your digestive system is looking for resources to fuel your body that the pill doesn’t have. That is why you take it with food, so your body gets what it needs plus an added bonus. Its kind of like tricking your pet take it’s medicine by hiding it in the pet’s food.
    Bio X4 can help you lose unwanted fat by increasing your metabolism. But this will only help you if your using the additional energy by being more active. If your body finds that you do not need the energy, it will store it as fat again. Exercise is great, but if your like me it is hard to keep up that routine. So get a hobby you love that makes you more active. Examples, hiking, biking, paintball, sports, gardening/landscaping, woodwork,automotive work. Pretty much anything that will make you use your body to accomplish a goal. Just get more physical than you normally would.
    Bio X4 may not be a solution for everyone. I suggest you watch the Dr. Lee video completely all the way through, and listen carefully to the information and explainations that are given. This is not a weight loss pill. It is a supplement that addresses digestive system issues that are found commonly in Americans. When these issues are addressed, it “may” lead to weight loss. Remember your goal should not be weight loss, but a healthier body. Not all weight loss is health for your body. When your healthy, you feel good, your body performs like you want it to, and you feel happier.

  34. HI AGAIN,

  35. Ijiust ordered 3 bottles of biox4. I have now received 3 emails showing 3 different orders. Please make sure that you send only the one order that I made,and be sure my credit card is only charged one time.

  36. I am doing much better with this product, My constipation is not as bad and my stomach pains have gone away. I think BIO-X4 is a great product!!!

  37. I think it is a shame a so called “doctor ” is taking advantage of consumers with this scam. Her license should be revoked

  38. I took BioX4 for about three weeks and had to discontinue it. I was having major problems with constipation and stomach upset. I went back to my usual probiotic and all of the problems disappeared in about three days. The only meds I take is a thyroid pill and I think it interacted with my thyroid medication because I was very lethargic. That along with the constipation make me quit it and unfortunately I bought a several month supply to try it out but couldn’t even get through one bottle. Do not recommend at all.

  39. I ordered 6 bottles of BIO-X4, I am almost done with the third bottle. I am still waiting for at least a pound of weight loss. I start having severe constipation I ADDED MORE FIBER TO MY DIET BY EATING MORE GREENS. THE CONSTIPATION IS BETTER NOW, BUT I AM STILL WAITING FOR SOME WEIGHT LOSS.

  40. I bought 3 bottles of the BIO X4 product and saw no results so I gave it the benefit of doubt and bought three more. There was a difference between the first order and the second as it upset my stomach. I called the company and was told someone would get back to me…nothing. I responded to multiple emails sent by Amy Lee but also heard nothing. My wife tried to use the second order and had the same results…upset stomach that lasted all day. Maybe this is their weight loss solution, you feel too sick to eat. I have two full bottles and more than half of the third bottle left so it is obvious we can’t take it. The guarantee offered by the company is worthless as no one will ever get back to you to discuss the problems much less provide a refund. It is another diet scam.

  41. I took a full three month supply of bio x 4 and lost 20 lbs. I have been the same weight my whole life and that was the first time I have seen my abs since highschool. about three months after I quit taking it, I gained the weight back. I am not overweight, just needed to tighten up a little and it worked for me

  42. I have a history of seizures. I have searched and have not found any reason why I should not take. Can you tell me if I can take it. I am seizure free for 2 years so I am cautious what I take. Thank you for time and information.
    Mary ann

  43. The post Office tried to deliver a package from you, but I wasn’t here. They left me a notice to go to the post office and pick it up with a charge of $10.08. I have rejected this delivery. The post office is sending it back to you as I reject it. DO NOT RESEND

  44. I order three bottles of Bio X4 .So far. I have not received a response as yet. I will like to know when i will receive my supply and which company you be shipping with. Thank you.

  45. My digestion issues have improved immensley since taking BioX4. Had slow digestion issues no matter how I ate before taking the product. Now, from meal to meal with supplement, I feel my intake is being digested and stomach emptying out quicker and improved without reflux or indegestion as I experienced for years prior to this supplement. I have appreciated the nutritional uptake improvements. Skin seems improved, as well as olfeelings of overall wellbeing. Most of all the acid reflux belly pain is almost gone. Before even water would trigger acid reflux. I did have gallbladder issue problems for years and now, with this product I have not experienced gallbladder attacks as before. Much improved, overall digestion issues on this supplement with month supply, so far, I have ingested BioX4 with meals.

    1. I was alarmed after reading that WATCH DOG REJECTS BIO-X14. After reading your reply I feel better. The part that BIO-X14 can cause WEIGHT gain is most alarming to my husband, who has 100 lbs. to loose! We will continue for 2 bottles, then see if we will return the other bottles. Phentaslim sounds like the new “diet” pill many are taking. I’m going to carefully monitor the results on this diet pill.

  46. I can’t believe that I just wasted 90 minutes of my life watching that video…knew they were going to try and sell me something. I have NEVER bought any diet scam in my life (now 54) and have been overweight my entire life. There will never be a lose weight pill EVER and the only way we can lose weight is to make drastic life changes! You must eat better, you must exercise, develop some self control,and you must work on your self respect. I can lose weight at the drop of a hat when I get motivated and have done it many times but have never gotten a hold on emotional over eating and depression. I weighed 427 pounds at my highest when I was an Executive Chef, became diabetic and couldn’t live with that so I went crazy and lost 100 pounds in 10 weeks. Stayed there for 15 years gained back 20 #’s and became diabetic again and now have just lost 70 #’s over the last 4 months by changing my diet and exercising daily….it all boils down to how bad do you want to get healthy? For right now I’m in a good place and sticking with it, hopefully I don’t fall off the merry go round and hit another low point in my life and crash. My advice to you all is to get motivated, stay strong, and do this for yourself and nobody else! Good Luck & God bless all of you!

  47. Eat vegetables. Not saying digestive troubles are simply solved, but for me it was. I’m a little overweight, also for a time, I didn’t “go” for days at a time. I went to the doctor, she preformed an xray and saw I was pretty much full. She recommended less processed food and more vegetables on a regular basis. Since my problem needed to be more immediately addressed, she said go on a plant based diet for at least a week. No meat or carbs. It worked. I ate many different plants that contain sufficient protein and felt better after just a few days.
    So in short -eat your vegetables. It should at least help.

  48. I would like to return my order. Have my bank card credited. Would like to get return package. Slip if needed. After I received them and showed them to him. Said definitively should take them.

    1. Would like to return product. My Dr. Said I should not take them. Due to some of the medication I am on. Send me a return slip, credit my debit card the full amount. One of the bottles was crushed

    2. You don’t have to publish this. I spent 533.43. Because I was so confident in your product.

  49. Bio x 4 did not work for me. I cut down on sugars did not eat any of the 3 foods they told you not to eat at nucific. I still gained weight. I switched to a Keto diet which has been working for me. I will not purchase that product again it was a waste of 50 dollars.

  50. Took 7 pills over a weekend with Bio x-4 for a 0 effect one way or another now suspecting the capsules contain inert ingredients or very ‘watered down’ capsules, per no effect. Waste of money on a dead product that does nothing IMHO.

  51. This is for Katt: I have your problem and I control it with Loperamide Hydrochloride which I buy at Walmart. I take it at the first sign of loose bowel and pain in abdomen. I have had accidents, and there is a new medication out that you can take on a daily basis that slows the peristalic action of the bowel…unfortunately it costs about 600+ a month, so I haven’t tried it. The one I’m talking about is the Equate brand called Anti-Diarrheal. Try it. Also, look up celiac disease and cut out the foods they recommend for a few weeks to see if that helps.

  52. I’ve read most every comment on this site. I believe everyone has a valid points with reference to their own experience. Pills of any kind will have a different effect on each of us. While something may work for one person it does not make sense that it will work for every person. Also, what I see is so many things going on at once, i.e. drinking more water/ or water before each meal. Cutting out fatty foods, packaged processed foods, wheat product, sugar, etc. So we all do several things at once to try to battle the bulge and irregularities in our systems. I wish there were a ” Magic Pill ” that would help all of us. However I do not believe there is. So my assessment here is simple, try one thing at a time, drink water before meals for a couple of weeks and see if that helps. Then maybe try cutting out packaged processed foods, see if that works. Then maybe try taking a probiotic or drink 3 to 4 cups of green tea a day. Do you see where this is going. Please don’t put all your faith in a “Magic Pill ” that costs a substantial amount of money to sustain your life. Money back guarantee or not and I don’t care how nice the customer service representative is. Please use common sense, get tested for food allergies, have your thyroid checked, eat better quality whole real food, take minimal pills, drink water as much as you can, exercise if you can’t walk sit in a chair and use your arms and torso, get enough sleep. Stop looking for the “Magic Pill” to fix everything. Most if not all companies in the US are in business to make money and they know how to market their product to us. They prey on our fears, our individual medical problems and our desire for a quick easy fix! I have lived with IBS for 14 years now, developed in my early forties for reasons unknown to me. I saw my doctor, then off to the GI specialist, diagnosed with IBS and told to eat more Fiber ( which by the way caused even more problems) and take immodium for my frequent bowell attacks. Well what that got me was a rectal prolapse because the immodium caused constipation that made me push hard during bowell movements. That resulted in surgery to fix the prolapse, then 3 years later another surgery to remove a section of my colon. Now, I can’t evacuate properly and the next step is an Ostomy bag. All avoidable had I done my research and learned more about my condition and that diet had more to do with my IBS than I knew at the time. Thanks to the medical profession I am messed up for life! We are responsible for our bodies and our health, if we don’t seek the answers for ourselves we will pay the price. I will not blindly follow the advice a a doctor who prescribes pills and does not look for the root cause of whatever condition I am suffering from at any given time. I will consult with my doctor but will seek to get to the root of the problem and resolve it without ” the Pill ” he says he can prescribe for ” That “…
    I have many female friends that suffer from “gut problems” all healthy athletic active women whom you would never think could have issue’s. We all have the same outlook with respect to our health, we want to stay in shape, feel better, have more energy, etc. My friends and I have all come to the conclusion we cannot rely on the medical profession to help us. The American diet and Corporate America is the culprit in most every case. The FDA has not done us any favors in this department. ( have you seen ads for the newest latest greatest drugs. The disclaimers during the ads should be enough to scare the crap out of you! Really, if you take drug XY or Z you can expect to suffer horrible side effects up to and including death and that’s ok to advertise on tv???
    Caution, Caution, Caution..research and learn, learn, learn. Good luck to all of you, Many blessings….

  53. I have tried the BioX4 for 2 weeks. It makes me jittery, increased heart rate, constipation, more irritable and feel terrible. I would not recommend this product.

    1. I have taken BIO.X4 for three months with no side effects, & found it 100% effective.
      I have to question your sites honesty, since you are promoting another product on your site?????

  54. I am not overweight and have good discipline regarding food consumption. I was looking for more energy and better sleep experience. I had only used the pills for 48 hours and during the second night of no sleep, most likely caused by the high caffeine content, I found my tummy rumbling and was getting quite uncomfortable. When I got up that morning I was in a lot of discomfort and finally contacted the company around noon when I could no longer tolerate the pain.The woman told me that this should only last a week or two while my body adjusted to the pills. I was shocked and decided right then and there to return the product. In my opinion any product that has such horrific side effects that must be endured for up to two weeks before any benefit is experienced is not something I want in my body.

  55. I took this for only 2 days & got headaches after each time. I didn’t think it was because of this supplement until I didn’t take them as well as reading more reviews. Needless to say they are going to be returned!

    1. I have to add if you bought this for weight loss there are more directions when you receive the product. The phone number you call says to drink 2 glasses of water with the supplement before your meal so you will eat less, stop eating when you feel 80% full & work out at least 30 minutes every day. Clearly you can do all of this even without taking the supplement & lose weight.

  56. For all of you with digestion issues; constipation, bloating, diarrhea, etc. A real solution is at Optimum Health Institute in San Diego, Ca
    It’s a holistic health center that has been in existence for over 40 years; you stay on site for at least 1 week you can attend classes that educate you on how you can heal your body with an organic raw diet, all-natural, holistic healing practices; body, mind and spirit. People from all over the world go there for healing.
    I highly recommend the Institute; I go at least once a year for 1-3 weeks. If money is an issue they have a scholarship fund. I don’t work for them or have any financial affiliation. I’ve seen miracles happen while being there. Look them up, do your own research.

    1. do you know if there is a sister business in Jacksonville, Florida?
      I would be interested in a class like this!

  57. I bought a 90 day supply and started taking this product July 21, will update every other week to this same post. I’m a 58 y/o male, 5’6″ 200 lbs, I exercise/cycle 4 – 5 days a week for about 1 hr, no issues. My problems are obviously, over weight and belly bloat (47″ around). Hispanic iron gut, no digestive issues, this probably why I’m chubby. I quit taking my other probiotics, and will try to follow the tips. No financial interest in this product

    1. I’ve been taking Bio X4 for 2 weeks. I have dropped 6 lbs. (194 lbs) and 1-1/2″ from my waist (45-1/2″). My energy levels are good and I am still exercising, 4-5 days a week. The trend looks good. I may have missed a dose or 2 during these last 2 weeks. Tried to stop eating at 80%, really can’t measure that, I just serve myself a reasonable portion of food and stop eating. No significant side effects. I’ll post again in a couple of weeks. I have no financial interest in this product.

    2. I’ve been taking Bio X4 for 4 weeks. I have dropped 2 lbs. (192 lbs) and 1? from my waist (44-1/2?) in the past 2 weeks. My energy levels continue the same I have slacked off on the exercise to 2-3 days a week, just busy. The trend is still good. I may have missed a couple of doses. I did notice my sugar intake increased — sweets :), and have cut it back in the past few days. No significant side effects. I’ll post again in a couple of weeks. I have no financial interest in this product.

    3. Lost interest…I leveled off weight at 190 lbs. no side effects and decided to quit taking the supplement. I guess I expected to lose weight quicker, it did help my bloating, but that to leveled off at 43″+/- with this supplement. I still have a bottle left and may try again in the next few weeks. Their instructions were like any other diet, drink plenty of water, exercise, and stop eating before you’re full. I have no financial interest in this product.

    4. I’ve been taking Bio X4 for 6 weeks (total weight lost, 10 lbs and 3″ from my waist). I have lost 2 more lbs. (190 lbs) and 1/2″ from my waist (44″) in the past 2 weeks. My energy levels the weight loss trend is still good. I continue to the exercise to 4-5 days a week. My appetite has somewhat diminished, it’s easier to stop eating and/or avoid tempting snacks. No significant side effects. I’ll post again in a couple of weeks. I have no financial interest in this product.

    5. I’ve been taking Bio X4 for 8 weeks, no weight loss or loss in belly size the past 2 weeks, energy levels still good. I continue to the exercise to 3-4 days a week. I’m stuck in a lull, I guess I need to lower my calorie consumption to kick start the weight loss, again. No significant side effects. I’ll post again in a couple of weeks. I have no financial interest in this product.

  58. I have been taking these for about a month now and even though I haven’t lost any weight, my digestion is good and I have a lot of energy. I haven’t had diarrhea like some have so I guess it’s just different for everyone. I cleaned up my home office and I don’t get sleepy at work anymore. I’m probably going to order more of these when I run out just because I like the way they make me feel. I get a lot more stuff done around my house plus I work a full-time job. I’m 51 and pre-menopausal.

  59. I bought two bottles of this after watching the Amy Lee video even though it is decidedly more expensive in Canada due to shipping and exchange rate. I took a leap of faith anyway. I have taken 3/4 of a bottle with only negative effects of headache and terrible constipation. I have had none of the advertised positive outcomes. I know it says it may take 90 days to work I cannot tolerate the side effects so am stopping it.

  60. I have no financial interest in this product. My goal of improving my digestive system was absolutely met. After 2 months of taking the Bio X4 I eat less and have more energy and “healed” an ailing bowel function. I just started the 3rd bottle. I have not experienced one negative side effect. Also I drink quite a bit of water daily so I do not drink the recommended amount before each meal. During the past year I began eating foods with active probiotics such as Kimchee, Kombucha and naturally fermented sauerkraut at every meal. So when I added Bio X4 it was the catalyst that changed my digestion. I believe the enzymes are the reason. I am 62 and eat organic foods as much as possible and stay away from foods that have numerous ingredients. I believe Dr. Lee is totally professional and I am happy with the results. I have spoken with her customer service on 2 occasions and both times were quite pleasant. I had a charge reversed from my mistake.

  61. Thank you for the reviews. I’m disappointed to see few positive reviews, and multiple “constipated consumers”. Everything sounded plausible, but I’m always of such blatant promotional ads claiming “secrets” without revealing much of anything but where to buy a new product. I already take a pro-biotic, and I don’t think more caffeing from ECGC would be good for me (I’m an Espresso addict).

  62. I have had this Bio X 4 on my mind for a great while. My problem is not so much to loose weight although I need to. But my condition is , I live in the bathroom , I’m too the point I don’t want to go out with my husband because for what ever reason causes it, I have to run to the bathroom and most times I don’t make it. I don’t over eat and I eat healthy exercise. But I feel like I’m dying inside. When I poop the way I have been for the past 3 weeks my bones hurt right through the marrow. I don’t have insurance nor can I afford it. So I’m confiding in you to help me decide to buy this or not.
    I’m really tired of crying in embarrassment every time I go somewhere and off I run to the bathroom and only to not make it and have to change all my cloths.please comment

    1. Katt, my sister has the same issue as well. She has cut out the fried greasy food and most importantly sweets, the processed kind. With this & a regular OTC probiotic, she is doing better. It’s manageable. Gluten intolerance is the culprit. You can be intolerant to gluten and it not be Celiac’s. Please keep a journal of the journey and when under control, add foods back one at a time. If flare ups occur when they’ve been added you will have an idea what the irritants are. Good luck. BTW: she uses Align. It took several attempts to find the one that works. They’re all different… like we are.

    2. I have exactly the same problem. I just ordered BIO x4 and hope it will help me because nothing worked for me up to now.

    3. My mom has been suffering similarly for a year and half. She went gluten free and that helped a lot but still occasionally had episodes with no known gluten intake.

      She has now been without an episode for 6 weeks and has been consuming gluten again with no relapse. The only change she made was unintentionally going off Lipitor. After some reading she discovered diarrhea can be a side effect.

    4. Katt,
      I read your note. You are allergic to wheat. Very allergic; believe me as I know all about your bathroom symptoms. Buy the Bio 4, cut out all wheat and refined sugar, and get your life back!! I promise.

    5. Dear Katt,
      I’m replying to your email for only one reason: you said you feel like you are dying side. And that got my attention.
      I’m going to take a risk here and step outside the usual replies. I have no vested interests and I don’t use Bio x4. I just saw the video and decided to check online for an side affects and negative reports (and my own consideration that combining all 4 protocols may be counter-productive. I haven’t finished my online research yet).
      But back to you: I’m going to recommend a book: “Dianetics, The Modern Science of Mental Health”, written by L. Ron Hubbard and published originally in 1950.
      It has sold over 20 million copies and has been translated into at least 20 languages or more. (I forget.)
      People take a car that doesn’t work to a mechanic, but in the case of the human mind, L. Ron Hubbard got under the hood and found the truth about the mind (not the brain) – and it isn’t what psychiatry says and it isn’t what psychology says either. This book was written for the typical person in 1950 – and they may have been better read than us here in 2016 .. or maybe not.

      My experience with Dianetics started in the early summer of 1968 when I was living with my 2 brothers in Cambridge, Massachusetts. I was in the kitchen opening a can of tuna fish and stupidly (seriously stupid) pushed the edge of the opened lid down with my index finger and got it caught between the edge of the can and the rough side of the can (because I was using an old-fashioned can opener in those days). Well, I freaked. My finger was trapped. I was afraid I was going to saw the end of the finger off. I also thought I was alone in the apt and scared to death. So, there I was crying and shouting and freaking to myself when suddenly I heard footsteps. My brother Michael was home. He came running into the kitchen, saw my dilemma, got hold of a small tool, and bent back the lid and got my finger loose. Of course it hurt. Of course it was bleeding (but at least it was still attached. Thank god.
      Then he grabbed a small cloth, bound it around my finger and hurried away and was back a minute later. He had just been reading “Dianetics”. He turned to the page that described how one administers the therapy. (In retrospect it was a bit funny, because he also read the number of the step. Like: “One: close your eyes” so he read the “Number one”, too.) Anyway. He had me follow his commands and in a few short minutes he had helped me to recover from the emotional trauma (because I HATE cuts, hate sharp edges, knives, etc.) and the pain receded, too. (I have a very low threshold for pain still and bumps and bruises hurt me like hell.) We ended the ‘Dianetic Assist” and I opened my eyes and took a (somewhat reluctant) look at the finger – with some prodding from him. So, I knew my finger was still there. And so glad. So very very glad. I really thought I was going to lose it. Which was one reason I had truly freaked out. It was throbbing (maybe) a little and … well, I had to smile. It really didn’t hurt. Was that possible? Yes. And he had saved me from sawing off my finger! We bandaged my finger and that was that.
      I really had no more attention on the finger, which was unusual, since I tend to closely nurse all wounds – even a paper cut. A few days later I took the bandage off to see what was happening, and the scar was the thinnest of white lines and then the scar faded. Gone. Which, when you think about it is about impossible. I still have small scars accumulated over the years from other times when I didn’t get an Assist.
      Anyway, I looked at the finger and it didn’t cause me the slightest reaction. I was really amazed. Usually I would labor over how bad something was and how it nearly killed me but in this case, I really was relaxed. And that just wasn’t my usual response. “What the heck was that you did?” I asked Michael. He showed me the book: Dianetics, The Modern Science of Mental Heath by L. Ron Hubbard. So, I started to read it. That was 1968.
      I still need a car mechanic but I gotta tell you: I know what the mind is composed of and I know how this mental therapy works. No psychiatry, no psychology garbage, no “your mother did it” or any other nonsense. And truthfully, I’ve been a fan ever since. I admit it.

      Your ‘feeling’ alerted me to the probability that you could benefit from knowing what the mind is composed of and how to help yourself. Just reading this book can be a big help to you, let alone having the procedure applied to you to identify the true source of this ‘feeling’. It could even save your life.

      I live in Los Angeles now. I graduated from the Massachusetts College of Art and Design back in 1979 and I moved to here to study more about Dianetics, because I found that it works. You are welcome to ignore this email (from a total stranger, I realize), or you are welcome to contact me. I am sincere. In any case, I wish you well.

    6. Katt,
      Leslie’s recommendation to look into Dianetics is part of the Scientology scam. You should definitely look into getting expert medical and/or nutritional advice. If you want to find out about Dianetics and Scientology watch Leah Reminis new series on A & E, or go to Tony Ortega or Mike Rinders websites.

    7. What I’ve seen on A&E with Leah Remini, Scientology is a “My way or the highway brainwashing”, Scary!!!

      Keep your loved ones around you for support.

    8. Oh, jeeze, stay away from Scientology. It’s a mind-control bogus bunch of needy unbalanced people, I don’t care how rich and affluent they are, they’re nuts. I had my own experiences with them when I was young and vulnerable and “searching” for answers while living in South Florida. I had intuitively decided that something just didn’t sit right with me and so I tried extricating myself from all things related to Scientology. It took nearly three years, and a move halfway across the country before they finally stopped hounding me!! Trust YOURSELF, do your own homework, yes, try new things, but listen to your inner voice for guidance. You have the answers.

      As for the BioX supplements, I’m here researching before I buy the product, and I’ve decided I’m going to try it. Those comments that report ill side effects are probably their bodies releasing toxins. It happens to most people when transitioning from a processed-food diet to something more healthful. I myself have lost nearly 50 pounds over the past year by eliminating sugar, flour and all GMO and processed food products from my diet. I eat like a damn pig, but it’s all fresh non-chemical REAL food. I also added lots of vitamins and probiotics and fermented foods. With everything I have learned this past year about REAL nutrition, I believe this BioX sounds like a very good product. Incidentally, regarding those comments that say they got sick or had bad reactions, I too, had what I call “events.” Four of them over the past year, to be exact. I got sick, sweaty, nauseous, headaches, even vomited, and pooped and pooped and pooped like crazy! It felt like a real bad case of the flu. Admittedly, it was scary. But I knew intuitively what was happening to my body. It would last, oh, I’d say 30 to 90 minutes at most, then I would rest, drink lemon or apple cider vinegar water, and then, viola! I would feel like a new woman! All of that was just my fat crappy disgusting guts releasing toxic gross poisons!! It happens.

      To any of you who have experienced negative side effects, please remember this possibility: When anyone transitions from a bad to a good diet, it’s almost inevitable to feel like crap for a minute on occasion. It’s your body releasing shit! Literally as well as figuratively. You gotta give yourself a chance.

      Now I’m going to purchase a 3-month supply of BioX. By the way, I’m just an ordinary woman from Omaha who happened to stumble across this product on Facebook this morning.

      Leslie, I’m wishing you (and anyone else who reads this) the best of luck. There is nothing in the world more important than our health.

    9. I can’t believe that you would take a woman that is clearly suffering and try to introduce her to Scientology!! Anyone that would consider this man’s email needs to watch Leah Remini’s 8 part documentary on A & E about this cult religion! I can’t speak for this product but I can speak on this horrible (fake religion!)

    10. DO NOT BECOME INVOLVED IN ANY WAY with Dianetics or Scientology. Your health will not be improved, but the quality of your life and your pocketbook will suffer.

      I was lured into the Church of Scientology after reading “Dianetics” I spent a ton of money to become “clear” (that is when you are never supposed to become sick again) and then OT3 in the Church of Scientology. I am not alone; there are thousands of us who managed to escape the lies and deceptions of the Church of Scientology.

      The Church scans sites like this one, where people are looking to improve their health or overcome a health issue. Then they innocently present their “solution” of their book, Dianetics. Don’t be fooled. I think these are dangerous people.

    11. It sounds as if you may have Celiac.. You may need to see a doctor. I do have problems with my digestive system with what I researched and sounds like IBS – Irritable Bowel Syndrome. Now I haven’t been taking Bio-X4 as it reads, I’m more of a good 1 pill a day thing so no weight loss. but, so far no ‘attacks’ of urgent diarrhea. I am about to stop because my heart seems to be racing. I’m on meds for High Blood pressure. inherited. Overweight by 15 lbs. I bought this hoping I would lose that 15 lbs. I opened this info up to see if this Bio-X4 could be the reason of my heart racing or of stress. My experience thus far. Perhaps you should seek medical testing for Celiac first.

    12. Oh, darn, I meant to address my long comment below to you Katt, not Leslie. Sorry about that ladies.

  63. I ordered three bottles for 129.99. Then I accidentally ordered 6 bottles for 199.99. I called the number and spoke to a very friendly non pushy customer service representative who refunded the 199.99 immediately. This interaction alone cuts down any type of suspicion that this is a scam.

  64. I started taking Bio X4 2 weeks ago and I have already seen great improvement in my digestion. Like others have said, I am taking this product to improve overall digestive health, not using it as a weight loss supplement per se. So far I am happy.

  65. Best ever experience with a refund. After answering questions about my reasons, Nucific immediately submitted a refund to my credit card. I believe there is good reason to consider the product–but I had pre-existing health issues that interacted badly with the formula. I think younger people will be unlikely to experience my problems.

  66. Week 2 on my bio X4 experiencing some GI issues gassiness discomfort nothing major right now expected it. will continue to keep everybody updated as I hope others will that have just started it. I do not have any financial interest in this product I do want to see if it helps with weight loss

  67. I started take bio-4x on june 4th. I am willing to give this a try, I want to work on my weight I know pills are not the quick fix, but from what they say of the benefit of the pills it sound great. I will keep you post on what happens.

  68. Thank you for your research. I live in Australia where money back guarantees are worthless if you buy a product internationally. I note that they do actually provide a mailing address to send the product back to if you are not satisfied with it, so many businesses offer a money back guarantee on return of product with out providing a return address, though I wonder, if you do not read your article whether they provide the return address with the product when they send it to you.

  69. thanks for the websIte. both the analysis and the comments are helpful.
    As a result I have come up with a plan to address the issues of my spouse and myself. Not this product….at this time.
    what would be helpful, so many say they will post with results, few do, though the attestations to money back are hopeful. i don’t know what can be done about more followups…. but it would make the website a lot more useful to me. perhaps a reminder occasionally that your website is active on the topic to those who have contributed, with an option to unsubscribe, of course….?
    also, i wonder often if a posting by the rep of the company answering concerns, id’d as a rep of the company of course, could shed some light. and there are questions posted seeking answers from professionAls perhaps of one sort or another…..those answers would have been interesting to me, so maybe a moderator of some kind?
    My spouse and I have suffered digestive tract problems since we caught a flu in California a few years ago. the desire to lose weight is secondary.
    my concerns on this product is: green tea, reputed to be less beneficial for males vs females according to my deceased spouse of chinese heritage, especially cold green tea.
    second, the probiotic is not fresh and not a mix I like. I have to confess I hadn’t taken the mix so seriously until I read these comments….and I thank you for that all that contributed.
    the digestive enzyme info is interesting but not compelling to me at this point. However we will do a trial of this to experience the claims in isolation.
    also noted this is a rest of your life product….i would always prefer a cure….so I will keep looking, I don’t want to be on a lifer program especially with another nation and especially if this product could damage my body’s production, which is neither indicated nor denied.
    No financial interest in the product (website requested posters id if so or not)
    thanks all.

    1. Sadly, people who are satisfied with a product do not often bother to come back and relate their story, but people who are dissatisfied do.
      Retailers say that for every one person who can bother to put pen to paper and send a complain there are 15 others who are unhappy, but cannot be bothered to complain. Likewise,I bet a customer has to be really really happy with a product before they bother to write to a supplier, except, of course, if they receive some sort of remuneration, either in cash, or more product

  70. Thanks Spam or not I need to have all kinds off opinions. No l don,t have any financial interest in this product.

  71. I ordered this product but decided to cancel after seeing the Canadian exchange rate on my cc after the purchase. I called the Customer Service line and they refunded my money hassle free. Does not seem to be a scam to me if they allow refunds this easily.

    1. BUT, do they refund postage, as an International customer, for me often postage is more than, or equal to the cost of the product, AND there is two way postage, with having to return the unused product

  72. I just bought and received my 4 bottles of Nucific. I will not start taking them till I talk with my Dr. I have been taking and making homemade remedies to lose weight for many years and nothing. I am not a big eater, but by watching there video, it made me realize that I was doing something wrong in my diet that made me buy the pruduct. I am a type 2 diabetis person for a couple of years already. I am in remission for non Hodgkins Lymophoma for 2 yrs. I went to my follow up appointment with my primary Dr. And she told me that I have to start dieting because my A1C was high and my colesterol is high. That I have to start cutting the roots of the tree. I been feeling tired, I have aches and pain everywhere. So I started doing my remedies for losing weight. So it work a little…I been in steroids for back problems, and that made my weight go up. So now I have lost a little weight maybe 5 pounds…but Inhave to drink every morning Vineger with lemon….and I can not do it anymore because it taste sour and strong. So I then saw this pruduct, and I said to my self…well this should work for me because is all natural stuff…why not give it a try. Now, by reading all comments bad and good about this product, I am scare to take it…because I don’t need another sickness in my life. I have been through so much in the past 3 years. I need to loss 75pounds the most…Again I am not a big eater and I don’t eat in fast food restaurants. But my mean problems is eating sweets. I am working on it believe me. So By reading about this product, I could see that it could work on me but I have to consult with my Dr. 1st.

  73. Thank you for your help. I am trying to loose the belly but wore and can easily be persuaded to try quick fixes. You saved me money.

  74. Firstly, there are a number of comments concerning the address “transparency” issue. That Nucific is a UPS post box. Not really a problem as the other address is Dr. Amy’s office address at 811 Wilshire Blvd. this is not an uncommon practice, i would be more concerned as it were if the phone numbers were a dead issue.
    What annoyed me most were the seemingly endless “special offers” that appeared urging me to buy additional bottles at a discount price in this ‘once, not to be repeated offer’. A sales tactic I don’t appreciate. Anyhoo, I did place an order for a one month supply, adequate to determine if this is a positive product. Actually, two weeks should suffice.
    I will do a follow up, as indicated by many others who have not actually done so.
    I DO NOT have any financial interest,at this time, in this product.

  75. I’m not a medical professional, but it would appear to me that mixing fiber (metamusel or benefiber) with a glass of water and drinking it before each meal would do the same as this pill and cost a lot less. Fiber will make you feel fuller, make you eat less and will keep your digestive track healthy and regular. The other ingredients are already produced in our body, except green tea, which isn’t good for you when taken in such high dosages. Just my opinion and 2 cents worth.

    1. Actually excessive amounts of those powder fiber supplements are BAD for your digestive system. I have been seeing a digestive doctor for many years and have been told that anything is bad for you in excessive amounts. Taking out sugars, preservatives (prepare meals with fresh ingredients and not processed or canned foods), and unhealthy oils and gluten usually are the first step to feeling better so that your body can do as designed. I am American, but married an Italian and see a HUGE difference in how other cultures (not just Italian) see food. It isn’t until the last 5 years or so that I see the “western culture” finding it’s way into their societies like with Burger Kings and McDonald’s being opened in Italy. The thing is, they don’t get a lot of business except from the tourist travelers and the younger generation. We went to a Burger King there recently and it was EMPTY. This I believe is a huge sign that we are not eating healthy and natural foods in America. Since changing my family’s diet to fresh prepared ingredients and taking out sugars and artificial sweeteners (which are actually considered toxins in other countries), we have been able to take out the health issues and feeling of “not well”. The best part is, making dinner is actually more enjoyable and doesn’t really take any longer than opening a can of processed vegetables and heating in the microwave or stove top. Adding extra FIBER is not how to cleanse your digestive system, it actually pollutes and clogs it. Eating a natural and healthier diet is how to cleanse naturally.

  76. I am totally confused, so I may exercise my 90-day guarantee as a precaution. I was not very concerned about weight loss, but would have appreciated a small side effect in that realm. I ordered a three month supply after viewing the online cartoon-like ad. I hoped for increased energy and the elimination of gas — otherwise, I had no digestive issues. I have not used the supplements strictly in accord with the directions, so I don’t want to say there was a problem. After a few days, I concluded that it had a diuretic effect which I did not need. I guess I was simply pursuing a “fountain of youth” so I was disappointed.

    1. That diuretic effect may present a problem for me. I’m already on a SGLT2 Inhibitor for my Type 2 diabetes, which has the same effect, so much so, that it lowers my blood pressure to the point I had to completely stop taking my Ace Inhibitor.

      I’m seeing my doctor very soon, and he may tell me to ship it back before I can even try it out, but hopefully one or both of their other products will benefit me without complications.

    2. There seems to be controversy about whether caffeine has a diuretic effect (medicinenet and I know that it does for me. Perhaps you can learn from the type of ingredients in this product and take other brands without the green tea extract. I have already been advised by my DO to take probiotics (and have been advised that you have to be careful what you buy) and I did a diagnostic test that showed many food intolerances. At the beginning I tried to avoid those foods but I felt emotionally deprived. So now I take my own digestive enzymes. I find that the probiotics and enzymes eliminate my bloating and gas most of the time. I may still need to find other enzymes that will help as the products vary with what is included. People think that I have lost weight just by the bloating difference 🙂

    3. Can you please tell me what enzymes you take and how you know to take these? I would like to learn.

  77. I have been on a sensible weight loss and exercise program for 3 months with fitbit. I have slowed down in the weight loss (natural I assume) and still have 40 lbs to go. I have been on BIO X4 for a week and feel great. The scale finally tipped down 3 pounds. I believe it is encouraging liver function and good flora. Otherwise I am healthy so have no concerns raised in other posts. Also I find the posts contradictory. Some have diarrhea and others constipation. I think evaluating your diet to healthy balance of foods with sound regular exercise is key. And sometimes we just need a little help … hoping BIO -X4 works. At this time I am happy.

  78. I just received my first bottle. I decided to start with just one a day. I have a lot of food allergies and wanted to take it slow. I’ll let you know what happens.

  79. I started taking Bio X4 3 times a day on 2/22/16. I am a 62 year old male. I never had a digestive issue before taking Bio X4. I was hoping to loss some weight and get more energetic. Basically I did not notice any difference from before I started taking Bio X4, in fact I gained about 3 pounds. I bought 5 bottles, and I called Nucific to request a refund. I sent back 2 full bottles last week and am still waiting for my credit which I expect sometime next week. Bio X4 did not do anything for me but I am sure it may help some people. I was really hoping to see some positive results but it did not happen for me.

  80. I must have a “sensitive” stomach… After taking this pill for less than a week, I encountered every “minor” side effect in a major way. I had to go to the doctor and get a prescription to kill all the bacteria.

    1. What kind of side effects did you have ? I just tried it for a few days and I’m experiencing some side effects as well.. I’m wondering if I should go see my doctor as well

  81. I am going into week three. I have followed directions to the tee. I have to be careful of what I eat since having gallbladder removed, there are triggers that send me running to the potty. After reading what yall have written I am wonder if it was the supplements that gave me the day of H last week. I have blamed it on eating a salad but prehaps not. I did ask them the question if I should stop my advocare probotic prior to using however I did not get an answer. I started taking it again on Friday morning after two miserable days. I will see what happens this week before determing to stay or or ditch it. I actually was disappointed to find I had lost zero as much as I had been going and going. I am not giving up yet, I will be very mindful of not eating any of my prior triggers. Now I am not sure about this but my morning blood sugar has been much better. I will see if that continues… Stay tuned week 3 in the works…if I gain an ounce this week I will return.

  82. Ok, here’s my major complaint: What are the THREE HARMFUL FOODS?

    I’m sick and tired of these types of ads dangling that “important information” and then having to wait. I’m not going to wait 5 minutes 10 or 45 minutes to know what Dr. Lee thinks of as the 3 most harmful foods.

    The method of advertising is scammy at best, and I no longer trust these cartoon drawing long format web pages that seem long on information and short on facts or facts that help a person learn *anything*.

    I have a decent attention spam, but they are turning people off quickly. At least, people like me.

    1. yogurt, wheat bread and cereal bars (because of sugar content) She does not like High Fructose corn syrup.

    2. Chris, during the first part of the video,she addressed bread, cereal bars, and yogurt Bas being the bad foods. My concern was how or why the ingredients in the pills are considered natural. Thoughts anyone?

  83. Dietpillwatchdog -while I appreciate what your website is doing to aid the consumer in making an educated decision before purchasing fraudulent products I must add that there is a documentary called ” Gut Reaction” that explores the link between our digestive health and immune system. I disagree with your statement that this product can weaken your immune system . What are you basing this on? There is a lot of evidence that probiotics and digestive enzymes boost our immune system. Albeit along with a healthy diet. I am willing to give this supplement a go. The video only suggests it can aid in weight loss by helping to improve the digestive system. Anyone with a lick of sense should know there are no magic diet pills to lose weight.

    1. Mary, you misread that. Go back and read it again. They never said Bio-4X would weaken your immune system. They said, and I’m quoting them, “May introduce infection if you [already] *have a weakened* immune system.” The bracketed text and emphasis are mine.

      In their second reference to immunity, they said, “Probiotics will not be suitable if you [already] *have a weakened immune system* or certain medical conditions as it may introduce bacteria and infection into your system.” Again, the bracketed text and emphasis are mine.

      Probiotics are bacteria and they serve a good purpose as long as you’re healthy. I have a friend with a suppressed immune system because of medication for Rheumatoid Arthritis and Sjögren syndrome, among others.

      When she had to take an antibiotic for another illness, it killed off some of the bacteria in her gut, which allowed another to grow wildly out of control. It’s called C. diff, short for Clostridium difficile.

      In fact, it’s so common for this to occur after taking clindamycin that my doctor told me they used to call it clindiff, when he was in med school. For exactly that reason, I have always taken a probiotic while & after taking clindamycin, just to maintain the balance in my gut.

      We all have C. diff in our gut and it serves a purpose in a healthy individual, because the right balance of other probiotics keeps the C. diff under control, but it can get out of hand when immunity is compromised.

      The same could happen with a strain of probiotic bacteria in Bio-4X if the Bio-4X upsets the balance. There are many more strains of probiotic bacteria which are NOT in Bio-4X and they can usually keep each other in check in a healthy gut.

  84. I’m 56 years of age, not overweight and in good health but looking to improve energy levels and reduce the sugar intake (as the catalyst of my digestive issues) I’ve ordered a three month supply and will try to post my results over that timeframe. I don’t expect any adverse side effects but will begin by taking 1/3 of the recommended dosage for the first week or longer depending on tolerance of the supplements and increase to the recommended dosage slowly. I’ve reached the point where caffeine and sugar are doing more bad than good and if this Bio-X4 helps me curb the cravings and increases my energy levels overall then that is what I want..

    1. Good idea, think I will do the same. Start slow and build up. If I can remember I will also come back and post my results. I do have some health issues and need to lose some weight. Years of antibiotics mixed in with over prescribed prednisone have ruined my immune system and body. Slowly but surely I am improving ( after 2 knee replacements and a Achilles’ tendon replacement) I am off of all pain meds. I have cataracts and hearing loss as well. All this at 55. I am a nurse who trusted to her fellow professional colleagues” you would be surprised how little Doctors and Nurses know about actual health. I went in a journey 2 years ago to improve my health and have not stopped yet.

  85. I have pretty much all of the symptoms that she talks about in the video, not helped by the fact that I am peri-menopausal and have had IBS all of my adult life. I am not sure I’m ready to plunk down that much money to give this product a try, but did want to ask what others think of the Lipase-Amylase-Bromelain trio that is mentioned in the video.

  86. I watched the video today and ordered the 3 month supply-$129.00, shipping is free. I also ended up ordering 12 more bottles in error. I called the customer service line and the woman was very helpful. I gave her the order numbers and they have started the refund process. I told her I ordered a total of 15 bottles by mistake. No questions asked and I received a confirmation email stating my refund is being processed. For me, I have a huge problem digesting ANYTHING natural. I will try this out to see how it works for me. I will also come back to give an update after a month.
    I am not being paid for this review.

    1. Update: After reading the reviews here and other sites, I decided to cancel my pending order on Sunday, April 3. I got my money refunded in full today.
      As others have stated, there is not a lot of real research on this and I don’t want to take a supplement for the rest of my life.

  87. I am considering purchasing this supplement. But noticed that their pricing actually went up from what a previous user posted. It is now $10 higher per bottle. Is it really worth it?

    Here is what their site has:

    BIO X4 – 1 Bottle
    RETAIL: $99 Discounted Price $49

    BIO X4 – 3 Bottles
    RETAIL: $297 Discounted Price $129

    BIO X4 – 6 Bottles
    6 Bottles RETAIL: $594 Discounted Pay $240

  88. I’m curious if this works for someone who has had gastric bypass. I had one done in 2001. I don’t absorb vitamins and nutrients from the food I eat. I have to have b-12 shots monthly, as well as iron infusion once every year to year and a half. I would love to eliminate the sugar cravings I have as well as the brain fog and low energy.

    1. I am curious about this too. And are there any other supplements or vitamins in them? I’m so tired of taking so many pills.

  89. I have no desire to lose weight. I have been in the same slightly-under weight since my teens and am into my 50s now, but I do have minor digestive and energy issues, and my sister does have weight and digestive problems. I ordered the 6 month supply and will share with her if she wants to try it. I’ll try to remember to report back and let you know how it’s going.

  90. Has anyone who has suffered the bad side effects considered taking less of the supplement and then building up to the recommended 3x daily? Perhaps the body isn’t ready for the shock and could do with just one capsule at the biggest meal of the day to start off and if results are good, up it to two for a while, and then three. Just a thought. I’m considering buying but after reading reviews, thinking maybe just finding good green tea and fimbriata supplements to take in addition to my current probiotic.

  91. Could I order it from Taiwan? I would like to order 180days Bio-X4 supplement, How about the shipping cost and payment? Thanks!


    1. I think it would be hard to do a blind or double blind test because they will tell you that everyone has a different profile (what and how much bacteria) is in your gut.

  93. I just ordered a few bottles to give it a try, the price is fair considering all it has in it. Let’s see how I do in a few weeks and hopefully with all the changes in my diet along with this, I hope to see a change. I have a son with a disability and there are times I can’t get out, but I do exercise in home. Plus I’m always having digestion problems, so hoping this will get me on track!

  94. I ordered the product this weekend and also bought a second one offered at a deep discount. I figure I will be able to see some results after two months. I do also take a probiotic and I have responded to that nicely. I thought Dr. Lee did a convincing job to encourage me to give it a try. I did lose 8 lbs. in two months without exercise (can’t I have arthritis in my hips and spine). I will let all know my results.

  95. I have bought this product and they stress that you drink 2 cups of water with each pill 3x a day, eat until you’re 80% full and exercise 30 minutes a day. After hearing this which was after my purchase I felt that I would definitely lose weight if just did those three things without taking the pill. Anyway my plans are to take the pill with the water requirements before each meal and exercise 3x a week. We’ll see what happens. They do state that weight loss will not occur if those 3 things aren’t done. Makes me go hmmm..

    1. I agree with the hmmm. It sounds like it is merely an expensive appetite suppressant, My suspicions arose when they said take the tablet with a glass of water before each meal. Of course if you are full of water and, maybe gelatine, you are not going to eat as much and will lose weight, EXCEPT, if you are an emotional eater when feeling physically full does not mean that you are psychologically satisfied.
      Obviously I have no financial interest in the product

    2. Have taken supplement for three days and I am an emotional eater. I have not been hungry in the evenings which usually kill me. I am aware that I need a subsitute for the comfort eating gives me so I take a walk and play Pokemon GO which I find really amusing. Have found that I am satisfied with small portions. My stomach is already loosing the bloat. No side effects and I am bi-polar and have not noticed any signaificant mood change. Did notice that I can feel where food is in my gut but do not have as much gas as I have been having. I am taking this for gut health the 2 pounds I’ve lost is a plus. I am 62 and somewhat over my ideal weight. I have no financial interest in this product.

  96. Will this help you even if your not looking to lose weight? Just to help out your stomach problems, cause I really can’t afford to lose any weight but my stomach is a mess…

  97. I started taking BIO-X 4 about 6 weeks ago and immediately experienced frequent diarrhea and abdominal cramps . I did loose a few pounds and my appetite was less. After about
    3weeks of taking the supplement, I still had diarrhea, so I stopped them. I am still having diarrhea 3weeks later. Very disappointed . Had hoped it would help my IBS but most likely made it worse.

  98. i would, like to know if this product really make you lose weight, and how long do you have to take it to see results.

  99. I am interested in gut health. I eat rather healthy, but I do eat sweets and bread too. But I do not enjoy the benefits that I would expect from my foods. So I am seriously curious for the follow-up replies that people have mentioned to come.

  100. I believe the product should be re-reviewed here for what it states it is. It isn’t about weight loss, it’s about improved digestion which is necessary for weight loss. I am wondering if it would pass this review overall if critiqued as a digestion suppliment instead of a weight loss pill.

  101. She clearly states that this is not a weight loss pill, these are pills to get your digestive track back inline and balanced. When you really think about everything she explained in the video it makes sense, and yes there are lot of things out there you can take but again are they 100% an not watered down…I am going to try this product…I ordered on bottle…just to test…everyone is different and results will not be the same…but as she said take the bottle to your Dr. first and see what they recommend as well….

  102. I’m considering placing an order for BioX4 in an effort to decrease the amount of money I have to fork out each month for supplements (digestive enzymes, probiotics, LipotropiX, L-Carnitine, B-12, B-6, D…I think that’s all :-S). Three of the supplements cost nearly $50 per month! Eight years ago, I was prescribed Levaquin to combat a bad case of pneumonia. It cleared up the pneumonia, thankfully, but drastically affected my overall health, post-pneumonia. I was grateful to have not ended up with ruptured tendons which, as I discovered later, is a more common side effect of the flouroquinilone antibiotics (Leverox, Cipro, Levaquin, etc; if these meds are in your medical history look up Flouroquinolone Toxicity because the side effects are NOT just typical short term reactions but can be a delayed and a lifetime systemic response). The Levaquin completely destroyed my gut health. I took me 3 years & Lord know how much $, after seeing specialists – allergist, rheumatologist, endocrinologist, gastroenterologist, etc. I even requested an elective colonoscopy, long before age 50! Who in their right mind does THAT?! I searched the internet trying to find others who suffered from the same symptoms I had (all of the ones, incidentally, mentioned in the BIOx4 video, plus a few “extras” like cramping & irregular periods, swollen ankles, and occasional batches of ringworm or sandpapery “rashes” that didn’t really itch and *excuse my candor* anal itching so bad I thought for sure I had those pin worms my mom assured me I’d get, as a child, if I put my fingers in my mouth!). The key word that kept popping up in my research was CANDIDA. So I went to my PCP, told my favorite nurse practitioner about my findings and she agreed that I was likely on the right track BUT since standard blood tests didn’t show yeast toxicity and colonoscopy didn’t show yeast damage (although I wonder how they can see signs of pre-candidiasis/infection yeast when everything gets flushed out the night before?) and since most medical associations consider chronic candida overgrowth as an illness that would require specific treatment “speculative and unproven”, my nurse practitioner couldn’t diagnose or treat it, at least not “on the record”. She suggested I keep researching, ask for help at health food stores, etc. Keep in mind that, since the 50’s, medical associations DO agree that antibiotic use depletes gut flora. And they have yet to say that, for otherwise healthy individuals, treating gut flora imbalance or “yeast overgrowth” is in any way HARMFUL, so if it’s an absolute last resort, I thought, why not try it? I purchased top of the line digestive enzymes and a candida cleanse (Candi-Gone by Renew Life) and I went cold turkey, changing my diet & eliminating everything that was recommended on the sheet that came with the supplements. I lost 10 pounds in the first week. I’m convinced that was all inflammation! Within 3 months I no longer had the brain fog, I was still losing weight without trying -no exercising or feeling hungry- and symptoms that I didn’t even relate to the yeast started to disappear like, dry skin, acid reflux, monthly cystic acne, PMS, dry cracked heels and hangnails, and, best of all, the addiction-like cravings for carbs was gone, too! My bowels were normal for the first time since, well, BIRTH, maybe but it took about 6 months and a couple prescriptions of Diflucan (after initial results, my nurse practitioner was – unofficially 🙂 – 100% on board!) to finally rid myself of the “pinwormy” itch.
    My point in sharing this crazy journey is to let Peter Brown, Jennifer and her husband and others who had an adverse reaction at first is to let you all know that when i first started with the Yeast Cleanse, there was a “Die-Off Period” for at least a week, maybe a bit longer, where I felt like I had the flu. I was sluggish, tired and even felt feverish although I wasn’t. There was no rhyme of reason to my bowel response – random times of the day, diarrhea sometimes, constipation at others or just feeling like I had to go but didn’t. And, like any addict kicking a habit, the sugar cravings were OFF THE CHARTS! The only things that kept me from raiding my kid’s Easter baskets was 1) I really couldn’t bear the non-stop itching anymore because there really is NO way to discreetly scratch some places when you’re at WalMart and 2)I’d paid some serious $ purchasing the cleanse program, enzymes and healthy foods just for MY diet (because if it says gluten free, kids won’t touch it!), so I wasn’t about to blow that investment just for a Tootsie Roll, a biscuit or that big, fat, juicy hunk of watermelon on my daughter’s plate.
    Perhaps, those of you who had adverse gut responses were just experiencing the Die Off phenomenon and you gave up too soon? Just a thought. After I try BioX4, I’ll write again (much more briefly, I promise) and let you know how it goes.

    1. Hello, Delta.
      I appreciate your report on your medical condition and the steps you have taken to correct it! Today is Tuesday 29 March 2016, and I am curious to hear if you have bought the BIO-X4. Because you have such a high awareness of your symptoms, I am eager to hear your report of BIO-X4. I am curious about the product, but I also have a level of caution (having been “burned” in the past by the acai berry, garcinia, and green coffee, etc…)! Please continue to contribute to this forum, Delta! We await your comments! I have NO financial interest in BIO-X4!

    2. OMG… described EVERYTHING I have been experiencing for quite some time now!!! What exactly did you buy and eliminate???

  103. I started taking Bio X4 about a week ago & have lost 5 pounds so far. I’ve had no GI side effects at all. The only side effects I’ve had are a little bit of jitteriness & I have to urinate more frequently. I’ve heard these 2 are common in user’s of green tea extract. I’ve been very happy with the product so far.

    1. Hello, Kelly.
      Today is Tuesday 29 March 2016, and about one month since your post on 26 February. In that post you said that you had lost five pounds in one week! Can you comment on what has happened in the past month? Have the “jitters” gone away? Still peeing more frequently? Still happy with the product? I have NO financial interest in BIO-X4. I am curious in the product, but also a tiny bit skeptical. I — and probably hundreds of others– await your next report, Kelly!

  104. I was looking up something that would help with my diabetic A1C and this product came up. After reading the reviews I am not sure I should take it or not.

  105. I echo the experience of the first comment… horrible diarrhea, cramping, chills. Nucific told me sometimes people have mild reactions. Mine took me to the emergency room. It’s well over a week off the pills & now my urine stream is weak although I feel as though I have to pee all the time. Save yourselves!!!

  106. Almost 10 years ago I had a bad experience with diverticular disease. It seemed to have been briught on by using a colon cleanse product. Have had no problems since. Would like some opinions/thoughts on trying this product. I am 55, about 90 lb’s overweight, have diabetes II, and other health issues related & non-related to obesity.

    1. Tyranni:

      I have diverticulosis and digestive issues. I watched Dr. Lee’s video presentation regarding Bio X4 and decided to order the product (a 3 month supply). I just started using my 3rd bottle about a month ago and I can’t praise the product enough. After the first bottle, I noticed that I could finally eat food without great discomfort. Now I no longer experience painful bloating and repetitive belching and extreme abdominal misery. My quality of life was truly miserable before using this Bio-X4 and I felt that I was running out of options or solutions. Now I enjoy eating and no longer fear it. No more bloating, no more burping in search of relief and no more pain and discomfort. This is truly a life changer. You should try it. I just bought 6 more bottles so I’m good for another 6 months. Seriously can’t praise this product enough though, before using it, I’d blow up like a baloon with a hard distended abdomen no matter what I ate and was always taking antacids, pepto etc. NOT ANYMORE

    2. Hi
      I have Diverticulitis,I took a heavy amount of Probiotics &antibiotics for a month& it killed the pain ,could not eat anything but yogurt plaine.I drink Naked Juice,& no red meat anymore fish&a little chicken sometimes,lots of veggies love sweets but not heavy at all but iI do crave them I hope this will help my tummy & my sugar cravings as well.I just ordered some .Will keep you posted,as I take it.Good luck everyone .Pamela

  107. I have been on this for about 10 days now. The first 3 or 4 days I felt constipated. And was wondering if I made the right decision. I decided to stick it out a bit longer and am happy I stayed with it, by about the 5 th day I was feeling so much better and even though I haven’t started to lose weight yet my digestive system is right on tract . Prior to starting Bio X 4 I my digestive tract was a mess and I will spare the details. I do have more energy and my stomach feels good. I have cut taking Prilosec from twice a day to once a day and hoping I can stop the Prilosec if I continue to get better . I I am no longer having severe heartburn and acid reflux. I will continue to take Bio X 4 just for this benefit alone . I will report if and when I Start to lose weight . From what I have read weight loss should start 5 to 6 weeks after taking as directed with eating healthy drinking the water with Bio x4 and 30 mins. A day of some form of exercise.

    1. Are you still taking this product? How has it affected your intestines and colon ? I’m more interested in that than losing weight, that would be a bonus.

    2. Hi Gaylene,
      What is your most recent update? Have you lost any weight? How has the product made you feel?

    1. Good catch!

      Anyone who doubts this should just go to theupsstorelocal[dot]com[slash]0044 to see that the address is indeed a UPS store and apparently #343 is just the box number where Nucific picks up their mail and shipments, an arrangement I’ve used in the past when I didn’t want to give out my home address.

    2. BTW, I just placed an order to try this out and the address on the invoice is yet another UPS Store, with Postal Mai Box 658 assigned to Nucific.

      578 Washington Blvd, PMB 658
      Marina Del Rey, CA 90292

      However, in one of their FAQs, they claim:

      “All orders ship from our climate-controlled facility within 24-48 hours. If you are in the continental US, your order will by shipped by the US Postal Service. Unless something goes wrong, you should receive your order within five business days.”

      So, they don’t even use UPS for shipment, but they won’t provide anything else for any corporate address, including the location of said “climate-controlled facility”.

      Kinda makes one think “Hmmmmm!”

      Does Nucific even own such a facility or does it exist only on paper and contract all of the raw material acquisition, production, material handling, packaging and shipment to another entity being concealed by both of these mailbox addresses.

    3. Aside from all of that, I learned from someone else’s post that ordering entitles the buyer to a deep discount on a larger quantity.

      Planning to give it a 90 day trial, I might have ordered a 90 day supply. However, I decided to only order one bottle (30 days) of each of their products. I was subsequently given the “one-time-only” opportunity to add 3 bottles (90 day supply) of each at a 32% discount on the Bio-4x, and 30% off the price of the other items. That worked out to about $100 +/- a buck or two, vs the usual $129 for 3 bottles, and I only paid $49 for the first bottle, vs $43 if I had included it in an original order for 3 bottles.

      In effect, this lowers the price to $150 +/- $1-2 for four of each product, or about $37.50 average per bottle, all of which are covered by the 90 day “no questions asked” guaranteed return for refund.

      I’ll be back with more information, after I determine whether I plan to continue with any or all of these. If I’m not satisfied, and I don’t get a FULL refund, the total is still small enough that I could just take them to Small Claims Court in Pennsylvania.

      Of course, it’s not likely they would hire an attorney to defend such a small claim. Airfare from California would be prohibitive for either of the owners to make an appearance either, so I would get my refund one way or another. I also have a business presence in California which would facilitate collection (at Nucific’s additional expense) if necessary.

  108. I’m wondering if any of you who were dissatisfied with the product have tried to get your money back. I would like to know if they follow through with their promise of money back guarantee or not. Thanks.

  109. I’ve taken this for 2 weeks now and have lost 5 pounds with no side effects. I take it with a 12-oz glass of water before each meal and I eat until I’m 80% full as they recommend.

    1. If you are drinking a 12 oz glass of water before your meals, won’t this fill you up with no calories? Which would cause you to lose weight.

  110. I have been looking for someone else on the internet that is having the same complications as my husband and I have had on it. I am a registered nurse and know how to monitor for side effects, for us this was not hard to do. I immediately had the bloated stomach and then for days had intestinal cramping that would not stop. I sat on the toilet for days. While I figured this was helping me loose weight it was not optimal. So I stopped taking it after just a few days. Then my husband started taking at the same time I did. Within a week he was not making it to the bathroom. The gas was horrible and the diarrhea was unbearable. I would not recommend this to anyone!!!

    1. See my reply, below. Perhaps your initial adverse reactions were a Die Off Phenomenon. I know that when I did a yeast cleanse that followed a similar protocol to the BioX4, I felt like I had the flu for a couple of weeks, with tummy troubles, general malaise and the achey-all-over feeling that, for me, always precedes a fever. But the fever never came, I lost 15 lb in the first three or four weeks and I felt better than I had in a LONG time by the end of one month. Perhaps you didn’t stick with it long enough?

    2. I would be very cautious with this product, it has green tea than in high amounts can damage the liver. I would have tried these pills for the digestive probiotics and enzymes. Once I was drinking two cups a day of green tea for about two weeks and sent me to the doctor feeling sick like having hepatitis! Be careful!

    3. Well, that makes it sound like a laxative, which can be bought OTC for a much cheaper price

  111. thank you for this review. My wife and I are looking to improve our overall health through good digestive health and your review has been helpful.