• Bio X4

    Bio X4 is a 4-in-1 weight management probiotic created by Nucific, who have a range of products that they claim are backed by science to help us operate at our best.

    The company says that they stick to four fundamental principles, which are applied to all their products. They claim only to use potent ingredients that are supported by clinical studies; the products are quality tested to ensure potency and purity. They are earth friendly, by using renewable energy and recyclable materials, and, lastly, all their products are made in California. Can Bio X4 live up to the hype?

    Bio X4 Pros

    • Comes with a 90-day money-back guarantee
    • Available from a reputable company – no associated scam issues

    Bio X4 Cons

    • No evidence that taking probiotics and digestive enzymes will lead to weight loss
    • May cause gastrointestinal side effects
    • Lack of positive testimonials
    Watchdog Rejected
    Bio X4
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    What You Need To Know About Bio X4

    After going over all the information we have collected, it would seem that Nucific Bio X4 may help some people improve their digestive health, but there is NO accepted evidence that it will help with weight loss.

    If your digestive system is functioning normally, there seems to be no reason to take this supplement.

    If you do have digestive problems, you should visit your doctor rather than trust a rather expensive and unproven OTC supplement. Although the fact that the company is run by trained medical professionals is encouraging, unfortunately, there is insufficient evidence to suggest that this supplement will be safe.

    What Are The Side Effects Of Bio X4?

    We feel that probiotics need a further clinical investigation to prove all the claims that have been made here and eliminate concerns about contamination and safety issues.

    There is mounting evidence that certain Lactobacillus probiotics can actually cause weight gain,

    Different Lactobacillus species are associated with different effects on weight change that are host-specific. Further studies are needed to clarify the role of Lactobacillus species in the human energy harvest and weight regulation. Attention should be drawn to the potential effects of commonly marketed lactobacillus-containing probiotics on weight gain. Source

    We like green tea extract for weight loss, as it is included in a lot of products nowadays and has been proven to help with weight loss goals.

    How Much Does Bio X4 Cost?

    One bottle (30-day supply) costs $49.00. Nucific seems to be a reputable company, and we love that they offer a guarantee on their products, something a lot of other companies could learn from.

    What we weren’t impressed with is the lack of testimonials on the official site and lack of clinical studies. How many people have actually tried this product and found it to work in the way they state?

    Our Verdict on Bio X4

    While Bio X4 is marketed very slickly, especially with the video marketing featuring Dr. Amy Lee, the jury is still out on probiotics and weight loss. Is it worth taking something that some evidence shows may cause weight gain? We feel that the best bet, if you want to experiment, is to consume a natural yoghurt every now and then.

    For now, we have no other choice but to reject this supplement. We do not recommend Bio X4 to our readers.

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    Bio X4 Review?

    Bio X4 Facts

    • Nucific is based in California -full contact details are provided
    • Each bottle contains 90 capsules or one month’s supply
    • Available to buy in a 6-month supply

    Trying to lose weight can be a tough journey, but there are some techniques that can make it easier, such as eating a healthy diet and exercising regularly. Sometimes a dietary supplement can make all the difference in the world, and Bio X4 says that it is designed to help:

    • Control hunger cravings
    • Boost the metabolism and burn fat
    • Give you more energy and nutrients from the food you eat
    • Make you feel more confident without gas and bloating after eating

    Bio X4 contains 4 blended compounds that work together in order to attack weight loss issues. This is perfect for people who would like a supplement that has no lactose, no fillers, uses 100% pure ingredients and uses vegetarian capsules. What’s not to like?

    The principle ingredient is the probiotic blend, which is said to contain 4 billion healthy bacteria per capsule, which is a heck of a lot, and is composed of a Lactobacillus blend and a Bifidobacterium blend. Probiotics are important for our health, and our bodies could not do without these colonies of the live bacteria and yeasts found naturally in our bodies. Lactobacillus is a bacteria that is naturally present in the stomach, which produces vitamin K and Lactase (which breaks down Lactose, the sugars in milk products). Bifidobacterium is a type of bacteria present in the colon flora in animals, as well as in the gastrointestinal tract in humans.

    Since the mid-1990s, probiotics and supplements containing them have been advertised as a way to benefit the digestion system and help with IBS, eczema, and oral health. However, the probiotic supplements and foods do not have any medical backing behind them, which could be a cause for concern.

    As well as a probiotic blend, Bio X4 also contains a digestive enzyme blend. Digestive enzymes are present in the body naturally and break down food molecules so that they can be absorbed by the body, and taking a supplement including them is said to improve digestion. Bio X4 also contains green tea extract, which is well known for its beneficial effects on health and weight loss. There is some evidence that suggests green tea can increase the speed of the metabolism, making you lose weight more effectively.

    The final ingredient in Bio X4 is Caralluma Fimbriata, a cactus extract that may help cause feelings of satiety to prevent overeating and food cravings.

    Bio X4 Concerns:

    • You may not notice any effects from this supplement
    • No independent customer feedback
    • Not safe for everyone. May introduce infection if you have a weakened immune system. Could be dangerous if you don’t realize

    What Does Bio X4 Claim To Do?

    The manufacturers claim that with Bio X4 you can:

    Take control of your appetite again, enhance your metabolism & digestion, and feel better than ever.

    The way that each ingredient blend works is explained:

    • Digestive enzymes that help get you the maximum amount of nutrients out of everything you eat.
    • 12 Billion Colony-Forming Units (CFUs) of probiotics to rebalance your digestive tract with healthy gut bacteria.
    • The appetite suppressing power of Caralluma Fimbriata.
    • EGCG, sourced from green tea extract, to help support your metabolism.

    To utilize Bio X4 to the best of its ability you have to take one capsule with each meal. When taken three times daily, an individual receives 12 billion CFU’s. More may be taken as needed. Supplementing each meal with digestive help that assists in processing your food and extracting the maximum amount of nutrients gives your body the tools it requires to operate at its peak level of performance.

    Does Bio X4 Work?

    When we look back over the facts, we don’t see how or why Bio X4 could help you lose weight, as there is no evidence for probiotics and digestive enzyme supplements aiding weight loss. While the green tea and Caralluma fimbriata look promising, the ingredient amounts seem inadequate.

    Probiotics for weight loss remain largely untrialled and untested. This form of medical science is in the early stages, and nobody knows for sure if probiotics are generally good to take in supplement form. In addition, they are not suitable for everyone as they come with the risk of introducing bacteria into your system.

    Not only are the weight loss claims unproven, but the claims about digestive enzymes are also unproven. We cannot see Nucific Bio X4 doing much for your health or your weight loss.

    What Are The Ingredients of Bio X4?

    Nucific Bio X4 is a probiotic supplement that looks to address digestive issues as well as help you lose weight. Serving size is equal to one capsule.

    Probiotic blend (4 billion):

    • Lactobacillus acidophilus blend (L. acidophilus, L. rhamnosus, L. planterum): Lactobacillus acidophilus is present in different parts of the body including intestines, mouth, and vagina where it helps protect against harmful bacteria and infection. It may help to protect against coronary heart disease. It may help improve lipid metabolism. However, it does require further evidence to prove these claims. Source
    • Bifidobacterium blend (B. lactis, B. animalis): This probiotic bacterium is found in some dairy products (including breast milk) and may help digestive disorders such as irritable bowel syndrome.

    Digestive enzyme blend (88mg):

    • Amylase: This enzyme is present in our saliva and helps us digest carbs, such as rice and potatoes. Some ingredients, such as Kelp and Garcinia Cambogia, prevent this digestive process and some people believe that doing this stops carbs from being absorbed by the body and turning to fat. Other people believe that digestive enzyme supplements help the body’s digestion and help weight loss.
    • Bromelain: This natural enzyme is found in pineapple. According to clinical research, it may be effective in helping to reduce pain and inflammation.
    • Lipase: This is a digestive enzyme, which is made in the pancreas and is lacking in some people who suffer from medical conditions, such as celiac or Crohn’s disease. Lipase breaks down, transports fats, and is essential to the digestive process. It may help with digestive issues such as indigestion and gas. Source

    Weight Management blend:

    • Green Tea (100mg): Clinical research has found that green tea has proven health benefits, and the antioxidants (EGCG and polyphenols) found to have anti-obesity and fat burning properties because of the effects upon the metabolism. Contains caffeine. Source

    Craving control blend (166mg):

    • Caralluma Fimbriata: Promising although unproven ingredient for weight loss that may reduce appetite. We covered this native Indian succulent plant in a previous investigation and were impressed. However, it requires further evidence because testing has been very limited. Source

    Does Bio X4 Have Any Side Effects?

    Everybody is different when it comes to supplements and the way he or she may react to them. Some are right as rain, and others feel side effects within moments of ingesting a product. With Bio X4 healthy people are unlikely to experience serious side effects, but the same cannot be said for those with underlying health conditions or a weakened immune system.

    Bio X4 could cause the following side effects:

    • Intestinal gas
    • Bloating
    • Abdominal pains/cramps
    • Nausea
    • Diarrhea
    • Painful urination
    • Joint pain

    If you are particularly sensitive to caffeine, which is present in green tea, you could experience the following:

    • Jitteriness
    • Sleep disturbances
    • Headaches
    Not suitable for individuals under 18. Avoid if you are pregnant or breastfeeding. Ask your doctor before taking this supplement. Probiotics will not be suitable if you have a weakened immune system or certain medical conditions as it may introduce bacteria and infection into your system. This supplement may cause drug interactions so speak to your doctor if you are taking prescription medication.

    Are There Any Customer Reviews For Bio X4?

    As far as user reviews go we have been unable to locate any reviews on the official site, but we did locate some on Amazon, and the findings were interesting. Here are a few of them:

    I tried one whole bottle and saw no results at all. No weight loss, no change in digestion, no change in appetite. Only benefit was it encouraged me to drink more water! I purchased directly through Bio-X4 which cost much less than on Amazon. Scam! Wish I could show no stars.

    I bought the Bio-x4 from the company’s website – Nucific. I took it diligently for about 3 weeks. I did not experience any positive effects, e.g., of probiotics. However, my sleep became more restless, and I started experiencing some water retention. I’m returning the product back to the company and hope to receive my money back. Don’t waste your time and money on this product!

    This company seems strange and perhaps shady. I bought Bio X4 because it sounded all natural; I thought even if I didn’t lose the weight I wanted to lose, the probiotics and green tea extract would still give me benefits. I bought several bottles because every time I went to check out a new, “better” deal would pop up. That should have been a red flag. As someone else already noted, the Google reviews also seem stacked in Nucific’s favor. All of the results are favorable to Nucific, but all are on web pages completely unfamiliar to me. When I ordered the product I thought it was because the product was so new, but months later, the Google results are still like that. I ended up with heartburn that I believe is related to probiotics (I admittedly could be wrong about this but have heard some people get heartburn from certain types of probiotics), so I tried to return the bottles I had not opened. Unfortunately the 90-day grace period was over, so I have lost significant money on my Nucific purchase with nothing noticeably gained on my end. The e-mails from the company are also strange, as are the recipes. Hard to explain but something seems fake or “off” about this company. I would not buy their products again.

    Going by these reviews, it seems like Bio X4 does not help with weight loss and it is making people doubt the company.

    Does Bio X4 Offer a Money-Back Guarantee?

    When it comes to important details, we feel that one of the most important is that a product must have a guarantee, so the user feels safe knowing that they won’t lose out if the product doesn’t work in the way they want it to. Nobody likes to be disappointed and realize they lost a lot of money for no reason.

    On the site, Nucific offers a full 90-day money-back guarantee. Here is what they say:

    If you’re not 110% satisfied by the results, send back your order within 90 days for a full refund – no questions asked. You will be absolutely amazed at just how quickly your body can change. See the results for yourself…

    Unfortunately, it doesn’t specify whether this applies to opened and unopened bottles, so we would suggest contacting them beforehand for confirmation. To claim a refund, you need to call 888-679-5520 Monday – Friday from 6am to 8pm, as well as weekends 5am to 5pm.

    Where Can I Buy Bio X4?

    Nucific Bio X4 is only available from the official site where there are 3 options available for you to choose from.

    One bottle (30-day supply) costs $49.00.

    Three bottles (90-day supply) costs $129.00.

    Six bottles (180-day supply) costs $240.00.

    There is free shipping on all orders over $50.

    Bio X4 Frequently asked Questions (FAQ)?

    What is Bio X4?

    Bio X4 is a 4-in-1 probiotic supplement that claims to help you lose weight, to help you take control of your cravings and to enhance your metabolism and digestion.

    What are the side effects of Bio X4?

    Bio X4 can cause gas, bloating, abdominal pain, nausea, diarrhea, joint pain, jitteriness, and headaches. If taken too close to bedtime, it may cause insomnia.

    What are the ingredients in Bio X4?

    Bio X4 contains four proprietary blends known as Probiotic Blend (lactobacillus acidophilus and bifidobacterium), Digestive Enzyme Blend (amylase, bromelain, and lipase), Weight Management Blend (green tea extract), and Craving Control Blend (Caralluma fimbriata).

    Does Bio X4 work?

    There is no evidence that probiotics could help with weight loss; the studies and clinical trials are scarce and inconclusive.

    How much does Bio X4 cost?

    A 30-day supply costs $49.00, a 90-day supply is $129.00, and a 180-day supply is $240.00.

    Who makes Bio X4?

    Bio X4 is manufactured by Nucific, a company based in California.

    How do I take Bio X4?

    Take one capsule with a meal, three times a day.

    Can I take Bio X4 if I have a health condition?

    Avoid if you are pregnant or breastfeeding. Probiotics are not recommended if you have a weakened immune system or certain medical conditions; it is recommended to see a doctor prior to the treatment.

    Does Bio X4 have a money-back guarantee?

    There is a 90-day money-back guarantee.

    How long has Bio X4 been around?

    The website only says that Bio X4 is ‘brand new’, but does not precise when it has been put on the market.

    Where can I buy Bio X4?

    Bio X4 can be bought online from the official Nucific website.

    Can I buy Bio X4 in stores?

    No, Bio X4 is only available online from the official website.

    How do I contact Bio X4 customer service?

    You can contact Nucific costumer service seven days a week via email or phone with the details they provide on their website. It is important to remember that their business hours are Pacific Time.

    Are there any Bio X4 coupons?

    At this time, there are no Bio X4 coupons.

    Are there any free samples of Bio X4?

    Nucific does not offer free samples for Bio X4.

    How does Bio X4 compare to Phentaslim?

    CriteriaBio X4 ComparisonPhentaslim comparison
    Clinically Proven Ingredients
    Side Effect Free
    Positive Customer Reviews
    24/7 Support
    Money-back Guarantee

    Disclaimer: Our reviews and investigations are based on extensive research from the information publicly available to us and consumers at the time of first publishing the post. Information is based on our personal opinion and whilst we endeavour to ensure information is up-to-date, manufacturers do from time to time change their products and future research may disagree with our findings. If you feel any of the information is inaccurate, please contact us and we will review the information provided.

    227 comments on “Bio X4”

    1. Phil says:

      Week 2 nothing yet……No side effect , no weight loss…..nothing

    2. Barbara says:

      I’m curious if this works for someone who has had gastric bypass. I had one done in 2001. I don’t absorb vitamins and nutrients from the food I eat. I have to have b-12 shots monthly, as well as iron infusion once every year to year and a half. I would love to eliminate the sugar cravings I have as well as the brain fog and low energy.

      1. Lisa Green says:

        I am curious about this too. And are there any other supplements or vitamins in them? I’m so tired of taking so many pills.

    3. Richard Mackey says:

      I have no desire to lose weight. I have been in the same slightly-under weight since my teens and am into my 50s now, but I do have minor digestive and energy issues, and my sister does have weight and digestive problems. I ordered the 6 month supply and will share with her if she wants to try it. I’ll try to remember to report back and let you know how it’s going.

    4. heather says:

      Has anyone who has suffered the bad side effects considered taking less of the supplement and then building up to the recommended 3x daily? Perhaps the body isn’t ready for the shock and could do with just one capsule at the biggest meal of the day to start off and if results are good, up it to two for a while, and then three. Just a thought. I’m considering buying but after reading reviews, thinking maybe just finding good green tea and fimbriata supplements to take in addition to my current probiotic.

      1. John says:

        That sounds like a reasonable approach to me, FWIW.

    5. Carolyn says:

      Do they do automatic shipping after the first order

      1. Ashley says:

        No. I just ordered it.

    6. Aries says:

      I would like to order the 180days BIO-X4, could it be possible to shipping to TAIWAN? Thanks!

    7. Aries says:

      Could I order it from Taiwan? I would like to order 180days Bio-X4 supplement, How about the shipping cost and payment? Thanks!

    8. DAVID says:


      1. John says:

        I think it would be hard to do a blind or double blind test because they will tell you that everyone has a different profile (what and how much bacteria) is in your gut.

    9. Marilyn says:

      Thank very helpful imformation

    10. Kelli says:

      I just ordered a few bottles to give it a try, the price is fair considering all it has in it. Let’s see how I do in a few weeks and hopefully with all the changes in my diet along with this, I hope to see a change. I have a son with a disability and there are times I can’t get out, but I do exercise in home. Plus I’m always having digestion problems, so hoping this will get me on track!

    11. Thom says:

      I ordered the product this weekend and also bought a second one offered at a deep discount. I figure I will be able to see some results after two months. I do also take a probiotic and I have responded to that nicely. I thought Dr. Lee did a convincing job to encourage me to give it a try. I did lose 8 lbs. in two months without exercise (can’t I have arthritis in my hips and spine). I will let all know my results.

    12. Joy C says:

      I have bought this product and they stress that you drink 2 cups of water with each pill 3x a day, eat until you’re 80% full and exercise 30 minutes a day. After hearing this which was after my purchase I felt that I would definitely lose weight if just did those three things without taking the pill. Anyway my plans are to take the pill with the water requirements before each meal and exercise 3x a week. We’ll see what happens. They do state that weight loss will not occur if those 3 things aren’t done. Makes me go hmmm..

      1. Maree says:

        I agree with the hmmm. It sounds like it is merely an expensive appetite suppressant, My suspicions arose when they said take the tablet with a glass of water before each meal. Of course if you are full of water and, maybe gelatine, you are not going to eat as much and will lose weight, EXCEPT, if you are an emotional eater when feeling physically full does not mean that you are psychologically satisfied.
        Obviously I have no financial interest in the product

        1. Iris says:

          Have taken supplement for three days and I am an emotional eater. I have not been hungry in the evenings which usually kill me. I am aware that I need a subsitute for the comfort eating gives me so I take a walk and play Pokemon GO which I find really amusing. Have found that I am satisfied with small portions. My stomach is already loosing the bloat. No side effects and I am bi-polar and have not noticed any signaificant mood change. Did notice that I can feel where food is in my gut but do not have as much gas as I have been having. I am taking this for gut health the 2 pounds I’ve lost is a plus. I am 62 and somewhat over my ideal weight. I have no financial interest in this product.

    13. jess says:

      Will this help you even if your not looking to lose weight? Just to help out your stomach problems, cause I really can’t afford to lose any weight but my stomach is a mess…

    14. koukab says:

      i used them.for 4 day i bad constipation.and frequent urination
      is that ok

    15. Jan says:

      I started taking BIO-X 4 about 6 weeks ago and immediately experienced frequent diarrhea and abdominal cramps . I did loose a few pounds and my appetite was less. After about
      3weeks of taking the supplement, I still had diarrhea, so I stopped them. I am still having diarrhea 3weeks later. Very disappointed . Had hoped it would help my IBS but most likely made it worse.

    16. ruby williams says:

      i would, like to know if this product really make you lose weight, and how long do you have to take it to see results.

    17. Trish says:

      I am interested in gut health. I eat rather healthy, but I do eat sweets and bread too. But I do not enjoy the benefits that I would expect from my foods. So I am seriously curious for the follow-up replies that people have mentioned to come.

    18. Digestion not weight loss says:

      I believe the product should be re-reviewed here for what it states it is. It isn’t about weight loss, it’s about improved digestion which is necessary for weight loss. I am wondering if it would pass this review overall if critiqued as a digestion suppliment instead of a weight loss pill.

    19. Felice says:

      She clearly states that this is not a weight loss pill, these are pills to get your digestive track back inline and balanced. When you really think about everything she explained in the video it makes sense, and yes there are lot of things out there you can take but again are they 100% an not watered down…I am going to try this product…I ordered on bottle…just to test…everyone is different and results will not be the same…but as she said take the bottle to your Dr. first and see what they recommend as well….

    20. Delta says:

      I’m considering placing an order for BioX4 in an effort to decrease the amount of money I have to fork out each month for supplements (digestive enzymes, probiotics, LipotropiX, L-Carnitine, B-12, B-6, D…I think that’s all :-S). Three of the supplements cost nearly $50 per month! Eight years ago, I was prescribed Levaquin to combat a bad case of pneumonia. It cleared up the pneumonia, thankfully, but drastically affected my overall health, post-pneumonia. I was grateful to have not ended up with ruptured tendons which, as I discovered later, is a more common side effect of the flouroquinilone antibiotics (Leverox, Cipro, Levaquin, etc; if these meds are in your medical history look up Flouroquinolone Toxicity because the side effects are NOT just typical short term reactions but can be a delayed and a lifetime systemic response). The Levaquin completely destroyed my gut health. I took me 3 years & Lord know how much $, after seeing specialists – allergist, rheumatologist, endocrinologist, gastroenterologist, etc. I even requested an elective colonoscopy, long before age 50! Who in their right mind does THAT?! I searched the internet trying to find others who suffered from the same symptoms I had (all of the ones, incidentally, mentioned in the BIOx4 video, plus a few “extras” like cramping & irregular periods, swollen ankles, and occasional batches of ringworm or sandpapery “rashes” that didn’t really itch and *excuse my candor* anal itching so bad I thought for sure I had those pin worms my mom assured me I’d get, as a child, if I put my fingers in my mouth!). The key word that kept popping up in my research was CANDIDA. So I went to my PCP, told my favorite nurse practitioner about my findings and she agreed that I was likely on the right track BUT since standard blood tests didn’t show yeast toxicity and colonoscopy didn’t show yeast damage (although I wonder how they can see signs of pre-candidiasis/infection yeast when everything gets flushed out the night before?) and since most medical associations consider chronic candida overgrowth as an illness that would require specific treatment “speculative and unproven”, my nurse practitioner couldn’t diagnose or treat it, at least not “on the record”. She suggested I keep researching, ask for help at health food stores, etc. Keep in mind that, since the 50’s, medical associations DO agree that antibiotic use depletes gut flora. And they have yet to say that, for otherwise healthy individuals, treating gut flora imbalance or “yeast overgrowth” is in any way HARMFUL, so if it’s an absolute last resort, I thought, why not try it? I purchased top of the line digestive enzymes and a candida cleanse (Candi-Gone by Renew Life) and I went cold turkey, changing my diet & eliminating everything that was recommended on the sheet that came with the supplements. I lost 10 pounds in the first week. I’m convinced that was all inflammation! Within 3 months I no longer had the brain fog, I was still losing weight without trying -no exercising or feeling hungry- and symptoms that I didn’t even relate to the yeast started to disappear like, dry skin, acid reflux, monthly cystic acne, PMS, dry cracked heels and hangnails, and, best of all, the addiction-like cravings for carbs was gone, too! My bowels were normal for the first time since, well, BIRTH, maybe but it took about 6 months and a couple prescriptions of Diflucan (after initial results, my nurse practitioner was – unofficially 🙂 – 100% on board!) to finally rid myself of the “pinwormy” itch.
      My point in sharing this crazy journey is to let Peter Brown, Jennifer and her husband and others who had an adverse reaction at first is to let you all know that when i first started with the Yeast Cleanse, there was a “Die-Off Period” for at least a week, maybe a bit longer, where I felt like I had the flu. I was sluggish, tired and even felt feverish although I wasn’t. There was no rhyme of reason to my bowel response – random times of the day, diarrhea sometimes, constipation at others or just feeling like I had to go but didn’t. And, like any addict kicking a habit, the sugar cravings were OFF THE CHARTS! The only things that kept me from raiding my kid’s Easter baskets was 1) I really couldn’t bear the non-stop itching anymore because there really is NO way to discreetly scratch some places when you’re at WalMart and 2)I’d paid some serious $ purchasing the cleanse program, enzymes and healthy foods just for MY diet (because if it says gluten free, kids won’t touch it!), so I wasn’t about to blow that investment just for a Tootsie Roll, a biscuit or that big, fat, juicy hunk of watermelon on my daughter’s plate.
      Perhaps, those of you who had adverse gut responses were just experiencing the Die Off phenomenon and you gave up too soon? Just a thought. After I try BioX4, I’ll write again (much more briefly, I promise) and let you know how it goes.

      1. Beekeroo says:

        Hello, Delta.
        I appreciate your report on your medical condition and the steps you have taken to correct it! Today is Tuesday 29 March 2016, and I am curious to hear if you have bought the BIO-X4. Because you have such a high awareness of your symptoms, I am eager to hear your report of BIO-X4. I am curious about the product, but I also have a level of caution (having been “burned” in the past by the acai berry, garcinia, and green coffee, etc…)! Please continue to contribute to this forum, Delta! We await your comments! I have NO financial interest in BIO-X4!

      2. Mrs. Scott says:

        OMG…..you described EVERYTHING I have been experiencing for quite some time now!!! What exactly did you buy and eliminate???

      3. Lisa Green says:

        Please update!

      4. Betty says:

        What was your experience I don’t see your follow up, please respond, I am considering to try it!. Thanks so

      5. Betty says:

        Hi Delta, please let me know what your experience was! Thanks!

    21. Kelly says:

      I started taking Bio X4 about a week ago & have lost 5 pounds so far. I’ve had no GI side effects at all. The only side effects I’ve had are a little bit of jitteriness & I have to urinate more frequently. I’ve heard these 2 are common in user’s of green tea extract. I’ve been very happy with the product so far.

      1. Beekeroo says:

        Hello, Kelly.
        Today is Tuesday 29 March 2016, and about one month since your post on 26 February. In that post you said that you had lost five pounds in one week! Can you comment on what has happened in the past month? Have the “jitters” gone away? Still peeing more frequently? Still happy with the product? I have NO financial interest in BIO-X4. I am curious in the product, but also a tiny bit skeptical. I — and probably hundreds of others– await your next report, Kelly!

    22. Marion says:

      I was looking up something that would help with my diabetic A1C and this product came up. After reading the reviews I am not sure I should take it or not.

    23. peter brown says:

      I echo the experience of the first comment… horrible diarrhea, cramping, chills. Nucific told me sometimes people have mild reactions. Mine took me to the emergency room. It’s well over a week off the pills & now my urine stream is weak although I feel as though I have to pee all the time. Save yourselves!!!

    24. Tyranni says:

      Almost 10 years ago I had a bad experience with diverticular disease. It seemed to have been briught on by using a colon cleanse product. Have had no problems since. Would like some opinions/thoughts on trying this product. I am 55, about 90 lb’s overweight, have diabetes II, and other health issues related & non-related to obesity.

      1. Shane says:


        I have diverticulosis and digestive issues. I watched Dr. Lee’s video presentation regarding Bio X4 and decided to order the product (a 3 month supply). I just started using my 3rd bottle about a month ago and I can’t praise the product enough. After the first bottle, I noticed that I could finally eat food without great discomfort. Now I no longer experience painful bloating and repetitive belching and extreme abdominal misery. My quality of life was truly miserable before using this Bio-X4 and I felt that I was running out of options or solutions. Now I enjoy eating and no longer fear it. No more bloating, no more burping in search of relief and no more pain and discomfort. This is truly a life changer. You should try it. I just bought 6 more bottles so I’m good for another 6 months. Seriously can’t praise this product enough though, before using it, I’d blow up like a baloon with a hard distended abdomen no matter what I ate and was always taking antacids, pepto etc. NOT ANYMORE

        1. Pamela says:

          I have Diverticulitis,I took a heavy amount of Probiotics &antibiotics for a month& it killed the pain ,could not eat anything but yogurt plaine.I drink Naked Juice,& no red meat anymore fish&a little chicken sometimes,lots of veggies love sweets but not heavy at all but iI do crave them I hope this will help my tummy & my sugar cravings as well.I just ordered some .Will keep you posted,as I take it.Good luck everyone .Pamela

    25. Gaylene says:

      I have been on this for about 10 days now. The first 3 or 4 days I felt constipated. And was wondering if I made the right decision. I decided to stick it out a bit longer and am happy I stayed with it, by about the 5 th day I was feeling so much better and even though I haven’t started to lose weight yet my digestive system is right on tract . Prior to starting Bio X 4 I my digestive tract was a mess and I will spare the details. I do have more energy and my stomach feels good. I have cut taking Prilosec from twice a day to once a day and hoping I can stop the Prilosec if I continue to get better . I I am no longer having severe heartburn and acid reflux. I will continue to take Bio X 4 just for this benefit alone . I will report if and when I Start to lose weight . From what I have read weight loss should start 5 to 6 weeks after taking as directed with eating healthy drinking the water with Bio x4 and 30 mins. A day of some form of exercise.

      1. Donna says:

        Are you still taking this product? How has it affected your intestines and colon ? I’m more interested in that than losing weight, that would be a bonus.

      2. Elaine says:

        Hi Gaylene,
        What is your most recent update? Have you lost any weight? How has the product made you feel?

      3. Lisa Green says:

        Please update!

    26. Fred says:

      Well the address is a UPS store, first red flag.

      1. Dave says:

        Good catch!

        Anyone who doubts this should just go to theupsstorelocal[dot]com[slash]0044 to see that the address is indeed a UPS store and apparently #343 is just the box number where Nucific picks up their mail and shipments, an arrangement I’ve used in the past when I didn’t want to give out my home address.

        1. Dave says:

          BTW, I just placed an order to try this out and the address on the invoice is yet another UPS Store, with Postal Mai Box 658 assigned to Nucific.

          578 Washington Blvd, PMB 658
          Marina Del Rey, CA 90292


          However, in one of their FAQs, they claim:

          “All orders ship from our climate-controlled facility within 24-48 hours. If you are in the continental US, your order will by shipped by the US Postal Service. Unless something goes wrong, you should receive your order within five business days.”

          So, they don’t even use UPS for shipment, but they won’t provide anything else for any corporate address, including the location of said “climate-controlled facility”.

          Kinda makes one think “Hmmmmm!”

          Does Nucific even own such a facility or does it exist only on paper and contract all of the raw material acquisition, production, material handling, packaging and shipment to another entity being concealed by both of these mailbox addresses.

          1. Lisa Green says:

            UPS automatically transfers to USPS for smaller packages.

        2. Dave says:

          Aside from all of that, I learned from someone else’s post that ordering entitles the buyer to a deep discount on a larger quantity.

          Planning to give it a 90 day trial, I might have ordered a 90 day supply. However, I decided to only order one bottle (30 days) of each of their products. I was subsequently given the “one-time-only” opportunity to add 3 bottles (90 day supply) of each at a 32% discount on the Bio-4x, and 30% off the price of the other items. That worked out to about $100 +/- a buck or two, vs the usual $129 for 3 bottles, and I only paid $49 for the first bottle, vs $43 if I had included it in an original order for 3 bottles.

          In effect, this lowers the price to $150 +/- $1-2 for four of each product, or about $37.50 average per bottle, all of which are covered by the 90 day “no questions asked” guaranteed return for refund.

          I’ll be back with more information, after I determine whether I plan to continue with any or all of these. If I’m not satisfied, and I don’t get a FULL refund, the total is still small enough that I could just take them to Small Claims Court in Pennsylvania.

          Of course, it’s not likely they would hire an attorney to defend such a small claim. Airfare from California would be prohibitive for either of the owners to make an appearance either, so I would get my refund one way or another. I also have a business presence in California which would facilitate collection (at Nucific’s additional expense) if necessary.

    27. Susan says:

      I’m wondering if any of you who were dissatisfied with the product have tried to get your money back. I would like to know if they follow through with their promise of money back guarantee or not. Thanks.

    28. Roberta says:

      I’ve taken this for 2 weeks now and have lost 5 pounds with no side effects. I take it with a 12-oz glass of water before each meal and I eat until I’m 80% full as they recommend.

      1. Sue says:

        If you are drinking a 12 oz glass of water before your meals, won’t this fill you up with no calories? Which would cause you to lose weight.

    29. Jennifer says:

      I have been looking for someone else on the internet that is having the same complications as my husband and I have had on it. I am a registered nurse and know how to monitor for side effects, for us this was not hard to do. I immediately had the bloated stomach and then for days had intestinal cramping that would not stop. I sat on the toilet for days. While I figured this was helping me loose weight it was not optimal. So I stopped taking it after just a few days. Then my husband started taking at the same time I did. Within a week he was not making it to the bathroom. The gas was horrible and the diarrhea was unbearable. I would not recommend this to anyone!!!

      1. Tyranni says:

        Have you returned the product? If so did you experience any problems?

      2. Delta says:

        See my reply, below. Perhaps your initial adverse reactions were a Die Off Phenomenon. I know that when I did a yeast cleanse that followed a similar protocol to the BioX4, I felt like I had the flu for a couple of weeks, with tummy troubles, general malaise and the achey-all-over feeling that, for me, always precedes a fever. But the fever never came, I lost 15 lb in the first three or four weeks and I felt better than I had in a LONG time by the end of one month. Perhaps you didn’t stick with it long enough?

        1. GreenTeaSick says:

          I would be very cautious with this product, it has green tea than in high amounts can damage the liver. I would have tried these pills for the digestive probiotics and enzymes. Once I was drinking two cups a day of green tea for about two weeks and sent me to the doctor feeling sick like having hepatitis! Be careful!

        2. Maree says:

          Well, that makes it sound like a laxative, which can be bought OTC for a much cheaper price

        3. BetaVee says:

          Delta, could you share what type of Yeast Cleanse that worked for you?

    30. Reed says:

      thank you for this review. My wife and I are looking to improve our overall health through good digestive health and your review has been helpful.

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