Bio X4

Updated May 16, 2019.
Published Aug 22, 2016.
Dr. Krystal Crawford, ND, MS
Medically reviewed by Dr. Krystal Crawford, ND, MS, written by Jane Weston.

Bio X4 contains 4 blended compounds that work together in order to attack weight loss issues. However, we don’t see how or why Bio X4 could help you lose weight as there is no evidence for probiotics and digestive enzyme supplements aiding weight loss. Added to this, is the lack of testimonials on the official site and lack of clinical studies.


  • Comes with a 90-day money-back guarantee
  • Available from a reputable company – no associated scam issues


  • No evidence that taking probiotics and digestive enzymes will lead to weight loss
  • May cause gastrointestinal side effects
  • Lack of positive testimonials
Bio X4
Bio X4 is a 4-in-1 weight management probiotic-created by Nucific, who have a range of products that they claim are backed by science to help us operate at our best.

The company says that they stick to four fundamental principles, which are applied to all their products. They claim only to use potent ingredients that are supported by clinical studies; the products are quality tested to ensure potency and purity. They are earth friendly, by using renewable energy and recyclable materials, and, lastly, all their products are made in California. Can Bio X4 live up to the hype?

Bio X4 Overview

What you need to know about Bio X4

After going over all the information we have collected, it would seem that Nucific Bio X4 may help some people improve their digestive health, but there is NO accepted evidence that it will help with weight loss.

If your digestive system is functioning normally, there seems to be no reason to take this supplement.

If you do have digestive problems, you should visit your doctor rather than trust a rather expensive and unproven OTC supplement. Although the fact that the company is run by trained medical professionals is encouraging, unfortunately, there is insufficient evidence to suggest that this supplement will be safe.

What are the side effects of Bio X4?

We feel that probiotics need a further clinical investigation to prove all the claims that have been made here and eliminate concerns about contamination and safety issues.

There is mounting evidence that certain Lactobacillus probiotics can actually cause weight gain:

Different Lactobacillus species are associated with different effects on weight change that are host-specific. Further studies are needed to clarify the role of Lactobacillus species in the human energy harvest and weight regulation. Attention should be drawn to the potential effects of commonly marketed lactobacillus-containing probiotics on weight gain. Source

We like green tea extract for weight loss, as it is included in a lot of products nowadays and has been proven to help with weight loss goals.

How much does Bio X4 cost?

One bottle (30-day supply) costs $49.00. Nucific seems to be a reputable company, and we love that they offer a guarantee on their products, something a lot of other companies could learn from.

What we weren’t impressed with is the lack of testimonials on the official site and lack of clinical studies. How many people have actually tried this product and found it to work in the way they state?

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Bio X4 Key Features

Bio X4 Key Points

  • Nucific is based in California – full contact details are provided
  • Each bottle contains 90 capsules or one month’s supply
  • Available to buy in a 6-month supply

Trying to lose weight can be a tough journey, but there are some techniques that can make it easier, such as eating a healthy diet and exercising regularly. Sometimes a dietary supplement can make all the difference in the world, and Bio X4 says that it is designed to help:

  • Control hunger cravings
  • Boost the metabolism and burn fat
  • Give you more energy and nutrients from the food you eat
  • Make you feel more confident without gas and bloating after eating

Bio X4 contains 4 blended compounds that work together in order to attack weight loss issues. This is perfect for people who would like a supplement that has no lactose, no fillers, uses 100% pure ingredients and uses vegetarian capsules. What’s not to like?

The principle ingredient is the probiotic blend, which is said to contain 4 billion healthy bacteria per capsule, which is a heck of a lot, and is composed of a Lactobacillus blend and a Bifidobacterium blend. Probiotics are important for our health, and our bodies could not do without these colonies of the live bacteria and yeasts found naturally in our bodies. Lactobacillus is a bacteria that is naturally present in the stomach, which produces vitamin K and Lactase (which breaks down Lactose, the sugars in milk products). Bifidobacterium is a type of bacteria present in the colon flora in animals, as well as in the gastrointestinal tract in humans.

Since the mid-1990s, probiotics and supplements containing them have been advertised as a way to benefit the digestion system and help with IBS, eczema, and oral health. However, the probiotic supplements and foods do not have any medical backing behind them, which could be a cause for concern.

As well as a probiotic blend, Bio X4 also contains a digestive enzyme blend. Digestive enzymes are present in the body naturally and break down food molecules so that they can be absorbed by the body, and taking a supplement including them is said to improve digestion. Bio X4 also contains green tea extract, which is well known for its beneficial effects on health and weight loss. There is some evidence that suggests green tea can increase the speed of the metabolism, making you lose weight more effectively.

The final ingredient in Bio X4 is Caralluma Fimbriata, a cactus extract that may help cause feelings of satiety to prevent overeating and food cravings.

Bio X4 Concerns:

  • You may not notice any effects from this supplement
  • No independent customer feedback
  • Not safe for everyone. May introduce infection if you have a weakened immune system. Could be dangerous if you don’t realize

What does Bio X4 claim to do?

The manufacturers claim that with Bio X4 you can:

Take control of your appetite again, enhance your metabolism & digestion, and feel better than ever.

The way that each ingredient blend works is explained:

  • Digestive enzymes that help get you the maximum amount of nutrients out of everything you eat.
  • 12 Billion Colony-Forming Units (CFUs) of probiotics to rebalance your digestive tract with healthy gut bacteria.
  • The appetite suppressing power of Caralluma Fimbriata.
  • EGCG, sourced from green tea extract, to help support your metabolism.

To utilize Bio X4 to the best of its ability you have to take one capsule with each meal. When taken three times daily, an individual receives 12 billion CFU’s. More may be taken as needed. Supplementing each meal with digestive help that assists in processing your food and extracting the maximum amount of nutrients gives your body the tools it requires to operate at its peak level of performance.

Does Bio X4 work?

When we look back over the facts, we don’t see how or why Bio X4 could help you lose weight, as there is no evidence for probiotics and digestive enzyme supplements aiding weight loss. While the green tea and Caralluma Fimbriata look promising, the ingredient amounts seem inadequate.

Probiotics for weight loss remain largely untrialled and untested. This form of medical science is in the early stages, and nobody knows for sure if probiotics are generally good to take in supplement form. In addition, they are not suitable for everyone as they come with the risk of introducing bacteria into your system.

Not only are the weight loss claims unproven, but the claims about digestive enzymes are also unproven. We cannot see Nucific Bio X4 doing much for your health or your weight loss.

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Bio X4 Ingredients

Nucific Bio X4 is a probiotic supplement that looks to address digestive issues as well as help you lose weight. Serving size is equal to one capsule.

Probiotic blend (4 billion):

  • Lactobacillus acidophilus blend (L. acidophilus, L. rhamnosus, L. planterum): Lactobacillus acidophilus is present in different parts of the body including intestines, mouth, and vagina where it helps protect against harmful bacteria and infection. It may help to protect against coronary heart disease. It may help improve lipid metabolism. However, it does require further evidence to prove these claims. Source
  • Bifidobacterium blend (B. lactis, B. animalis): This probiotic bacterium is found in some dairy products (including breast milk), and may help digestive disorders such as irritable bowel syndrome.

Digestive enzyme blend (88mg):

  • Amylase: This enzyme is present in our saliva and helps us digest carbs, such as rice and potatoes. Some ingredients, such as Kelp and Garcinia Cambogia, prevent this digestive process and some people believe that doing this stops carbs from being absorbed by the body and turning to fat. Other people believe that digestive enzyme supplements help the body’s digestion and help weight loss.
  • Bromelain: This natural enzyme is found in pineapple. According to clinical research, it may be effective in helping to reduce pain and inflammation.
  • Lipase: This is a digestive enzyme, which is made in the pancreas and is lacking in some people who suffer from medical conditions, such as celiac or Crohn’s disease. Lipase breaks down, transports fats, and is essential to the digestive process. It may help with digestive issues such as indigestion and gas. Source

Weight Management blend:

  • Green Tea (100mg): Clinical research has found that green tea has proven health benefits, and the antioxidants (EGCG and polyphenols) found to have anti-obesity and fat burning properties because of the effects upon the metabolism. Contains caffeine. Source

Craving control blend (166mg):

  • Caralluma Fimbriata: Promising although unproven ingredient for weight loss that may reduce appetite. We covered this native Indian succulent plant in a previous investigation and were impressed. However, it requires further evidence because testing has been very limited. Source

Bio X4 Side Effects

Everybody is different when it comes to supplements and the way he or she may react to them. Some are right as rain, and others feel side effects within moments of ingesting a product. With Bio X4 healthy people are unlikely to experience serious side effects, but the same cannot be said for those with underlying health conditions or a weakened immune system.

Bio X4 could cause the following side effects:

  • Intestinal gas
  • Bloating
  • Abdominal pains/cramps
  • Nausea
  • Diarrhea
  • Painful urination
  • Joint pain

If you are particularly sensitive to caffeine, which is present in green tea, you could experience the following:

  • Jitteriness
  • Sleep disturbances
  • Headaches
Caution: Not suitable for individuals under 18. Avoid if you are pregnant or breastfeeding. Ask your doctor before taking this supplement. Probiotics will not be suitable if you have a weakened immune system or certain medical conditions as it may introduce bacteria and infection into your system. This supplement may cause drug interactions so speak to your doctor if you are taking prescription medication.

Bio X4 Customer Feedback

As far as user reviews go we have been unable to locate any reviews on the official site, but we did locate some on Amazon, and the findings were interesting. Here are a few of them:

I tried one whole bottle and saw no results at all. No weight loss, no change in digestion, no change in appetite. Only benefit was it encouraged me to drink more water! I purchased directly through Bio-X4 which cost much less than on Amazon. Scam! Wish I could show no stars.

I bought the Bio-x4 from the company’s website – Nucific. I took it diligently for about 3 weeks. I did not experience any positive effects, e.g., of probiotics. However, my sleep became more restless, and I started experiencing some water retention. I’m returning the product back to the company and hope to receive my money back. Don’t waste your time and money on this product!

This company seems strange and perhaps shady. I bought Bio X4 because it sounded all natural; I thought even if I didn’t lose the weight I wanted to lose, the probiotics and green tea extract would still give me benefits. I bought several bottles because every time I went to check out a new, “better” deal would pop up. That should have been a red flag. As someone else already noted, the Google reviews also seem stacked in Nucific’s favor. All of the results are favorable to Nucific, but all are on web pages completely unfamiliar to me. When I ordered the product I thought it was because the product was so new, but months later, the Google results are still like that. I ended up with heartburn that I believe is related to probiotics (I admittedly could be wrong about this but have heard some people get heartburn from certain types of probiotics), so I tried to return the bottles I had not opened. Unfortunately the 90-day grace period was over, so I have lost significant money on my Nucific purchase with nothing noticeably gained on my end. The e-mails from the company are also strange, as are the recipes. Hard to explain but something seems fake or “off” about this company. I would not buy their products again.

Going by these reviews, it seems like Bio X4 does not help with weight loss and it is making people doubt the company.

Bio X4 Money-Back Guarantee

When it comes to important details, we feel that one of the most important is that a product must have a guarantee, so the user feels safe knowing that they won’t lose out if the product doesn’t work in the way they want it to. Nobody likes to be disappointed and realize they lost a lot of money for no reason.

On the site, Nucific offers a full 90-day money-back guarantee. Here is what they say:

If you’re not 110% satisfied by the results, send back your order within 90 days for a full refund – no questions asked. You will be absolutely amazed at just how quickly your body can change. See the results for yourself…

Unfortunately, it doesn’t specify whether this applies to opened and unopened bottles, so we would suggest contacting them beforehand for confirmation. To claim a refund, you need to call 888-679-5520 Monday – Friday from 6am to 8pm, as well as weekends 5am to 5pm.

Where To Buy Bio X4

Nucific Bio X4 is only available from the official site where there are 3 options available for you to choose from.

  • One bottle (30-day supply) costs $49.00
  • Three bottles (90-day supply) costs $129.00
  • Six bottles (180-day supply) costs $240.00

There is free shipping on all orders over $50.

Watchdog Verdict

While Bio X4 is marketed very slickly, especially with the video marketing featuring Dr. Amy Lee, the jury is still out on probiotics and weight loss. Is it worth taking something that some evidence shows may cause weight gain? We feel that the best bet if you want to experiment, is to consume a natural yoghurt every now and then.

For now, we have no other choice but to reject this supplement. We do not recommend Bio X4 to our readers.

Bio X4 Frequently Asked Questions (FAQ)

What is Bio X4?

Bio X4 is a 4-in-1 probiotic supplement that claims to help you lose weight, to help you take control of your cravings and to enhance your metabolism and digestion.

What are the side effects of Bio X4?

Bio X4 can cause gas, bloating, abdominal pain, nausea, diarrhea, joint pain, jitteriness, and headaches. If taken too close to bedtime, it may cause insomnia.

What are the ingredients in Bio X4?

Bio X4 contains four proprietary blends known as Probiotic Blend (lactobacillus acidophilus and bifidobacterium), Digestive Enzyme Blend (amylase, bromelain, and lipase), Weight Management Blend (green tea extract), and Craving Control Blend (Caralluma fimbriata).

Does Bio X4 work?

There is no evidence that probiotics could help with weight loss; the studies and clinical trials are scarce and inconclusive.

How much does Bio X4 cost?

A 30-day supply costs $49.00, a 90-day supply is $129.00, and a 180-day supply is $240.00.

Who makes Bio X4?

Bio X4 is manufactured by Nucific, a company based in California.

How do I take Bio X4?

Take one capsule with a meal, three times a day.

Can I take Bio X4 if I have a health condition?

Avoid if you are pregnant or breastfeeding. Probiotics are not recommended if you have a weakened immune system or certain medical conditions; it is recommended to see a doctor prior to the treatment.

Does Bio X4 have a money-back guarantee?

There is a 90-day money-back guarantee.

How long has Bio X4 been around?

The website only says that Bio X4 is ‘brand new’, but does not precise when it has been put on the market.

Where can I buy Bio X4?

Bio X4 can be bought online from the official Nucific website.

Can I buy Bio X4 in stores?

No, Bio X4 is only available online from the official website.

How do I contact Bio X4 customer service?

You can contact Nucific customer service seven days a week via email or phone with the details they provide on their website. It is important to remember that their business hours are Pacific Time.

Are there any Bio X4 coupons?

At this time, there are no Bio X4 coupons.

Are there any free samples of Bio X4?

Nucific does not offer free samples for Bio X4.

How does Bio X4 compare to Phentaslim?

Criteria Bio X4 Comparison Phentaslim comparison
Clinically Proven Ingredients
Side Effect Free
Positive Customer Reviews
24/7 Support
Money-back Guarantee

Disclaimer: Our reviews and investigations are based on extensive research from the information publicly available to us and consumers at the time of first publishing the post. Information is based on our personal opinion and whilst we endeavour to ensure information is up-to-date, manufacturers do from time to time change their products and future research may disagree with our findings. If you feel any of the information is inaccurate, please contact us and we will review the information provided.

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