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Bio X4

Bio X4 is a 4-in-1 weight management probiotic created by Nucific, who have a range of products, that they claim are backed by science to help us operate at our best.

The company says that they stick to four fundamental principles, which are applied to all their products. They claim to only use potent ingredients that are supported by clinical studies, the products are quality tested to ensure potency and purity. They are earth friendly, by using renewable energy and recyclable materials, and lastly all their products are made in California. Can Bio X4 live up to the hype?

Bio X4 Pros

  • Comes with a 90 Day money-back guarantee
  • Available from a reputable company – no associated scam issues

Bio X4 Cons

  • No evidence that taking probiotics and digestive enzymes will lead to weight loss
  • May cause gastro intestinal side effects
  • Lack of positive testimonials
Watchdog Rejected
Bio X4
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What You Need To Know About Bio X4

After going over all the information we have collected it would seem that Nucific Bio X4 may help some people improve their digestive health but there is NO accepted evidence that it will help with weight loss.

If your digestive system is functioning normally, there seems to be no reason to take this supplement.

If you do have digestive problems, you should visit your doctor rather than trust a rather expensive and unproven OTC supplement. Although, the fact that the company is run by trained medical professionals is encouraging, unfortunately there is no sufficient evidence to suggest that this supplement will be safe.

What Are The Side Effects Of Bio X4?

We feel that probiotics need further clinical investigation to prove all the claims that have been made here and eliminate concerns about contamination and safety issues.

There is mounting evidence that certain Lactobacillus probiotics can actually cause weight gain,

Different Lactobacillus species are associated different effects on weight change that are host-specific. Further studies are needed to clarify the role of Lactobacillus species in the human energy harvest and weight regulation. Attention should be drawn to the potential effects of commonly marketed lactobacillus-containing probiotics on weight gain. Source

We like green tea extract for weight loss, as it is included in a lot of products nowadays and has been proven to help with weight loss goals.

How Much Does Bio X4 Cost?

One bottle (30-day supply) costs $49.00. Nucific seem to be a reputable company and we love that they offer a guarantee on their products, something a lot of other companies could learn from.

What we weren’t impressed with is the lack of testimonials, on the official site and lack of clinical studies. How many people have actually tried this product and found it to work in the way they state?

Our Verdict on Bio X4

While Bio X4 is marketed very slickly, especially with the video marketing featuring Dr Amy Lee, the jury is still out on Probiotics and weight loss. Is it worth taking something that some evidence may cause weight gain? We feel that the best bet, if you want to experiment, is take consume a natural Yoghurt every now and then.

For now, we have no other choice but to reject Bio X4.

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Bio X4 Review?

Bio X4 Facts

  • Nucific is based in California. Full contact details are provided
  • Each bottle contains 90 capsules or one month’s supply
  • Available to buy in 6-month supply

Trying to lose weight can be a tough journey but there are some things than can make it easier, such as eating a healthy diet and exercising regularly. Sometimes a dietary supplement can make all the difference in the world and Bio X4 says that it is designed to help;

  • Control hunger cravings
  • Boost the metabolism and burn fat
  • Give you more energy and nutrients from the food you eat
  • Make you feel more confident without gas and bloating after eating

Bio X4 contains 4 blended compounds that work together in order to attack weight loss issues. This is perfect for people who would like a supplement that has no lactose, no fillers, uses 100% pure ingredients and vegetarian capsules as well. What’s not to like?

The principle ingredient is the probiotic blend, which is said to contain 4 billion healthy bacteria per capsule, which is a heck of a lot, and is composed of a Lactobacillus blend and a Bifidobacterium blend. Probiotics are important for our health and our bodies could not do without these colonies of the live bacteria and yeasts founds naturally in our bodies. Lactobacillus is a bacteria that is naturally present in the stomach, which produces vitamin K and Lactase (which breaks down Lactose, the sugars in milk products). Bifidobacterium is a type of bacteria present in the colon flora in animals, as well as in the gastrointestinal tract in humans.

Since the mid 1990s, probiotics and supplements containing them have been advertised as a way to benefit the digestion system and help with IBS, eczema, and oral health. However the probiotic supplements and foods do not have any medical backing behind them, which could be a cause for concern.

As well as a probiotic blend, Bio X4 also contains a digestive enzyme blend. Digestive enzymes are present in the body naturally and break down food molecules so that they can be absorbed by the body and taking a supplement including them is said to improve digestion. Bio X4 also contains green tea extract, which is well known for its beneficial effects upon health and weight loss. There is some evidence that suggests green tea can increase the speed of the metabolism, making you lose weight more effectively.

The final ingredient in Bio X4 is Caralluma Fimbriata, a cactus extract that may help cause feelings of satiety to prevent over eating and food cravings.

Bio X4 Concerns:

  • You may not notice any effects from this supplement
  • No independent customer feedback
  • Not safe for everyone. May introduce infection if you have a weakened immune system. Could be dangerous if you don’t realise

What Does Bio X4 Claim To Do?

The manufacturers claim that with Bio X4 you can:

Take control of your appetite again, enhance your metabolism & digestion, and feel better than ever.

The way that each ingredient blend works is explained:

  • Digestive enzymes that help get you the maximum amount of nutrients out of everything you eat.
  • 12 Billion Colony-Forming Units (CFUs) of probiotics to rebalanace your digestive tract with healthy gut bacteria.
  • The appetite suppressing power of Caralluma Fimbriata.
  • EGCG, sourced from green tea extract, to help support your metabolism.

To utilize Bio X4 to the best of it’s ability you have to take 1 capsule with each meal. When taken 3 times daily, an individual receives 12 billion CFU’s. More may be taken as needed. Supplementing each meal with digestive help that assists in processing your food and extracting the maximum amount of nutrients gives your body the tools it requires to operate at its peak level of performance.

Does Bio X4 Work?

When we look back over the facts we don’t see how or why Bio X4 could help you lose weight, as there is no evidence for probiotics and digestive enzyme supplements aiding weight loss. While the Green Tea and Caralluma Fimbriata look promising, the ingredient amounts seem inadequate.

Probiotics for weight loss remain largely untrialled and untested. This form of medical science is in the early stages and nobody knows for sure if probiotics are generally good to take in supplement form. In addition, they are not suitable for everyone as they come with the risk of introducing bacteria into your system.

Not only are the weight loss claims unproven, but also the claims about digestive enzymes are also unproven. We cannot see Nucific Bio X4 doing much for your health or your weight loss.

What Are The Ingredients of Bio X4?

Nucific Bio X4 is a probiotic supplement that looks to address digestive issues as well as help you lose weight. Serving size is equal to one capsule.

Probiotic blend (4 billion):

  • Lactobacillus acidophilus blend (L. acidophilus, L. rhamnosus, L. planterum): Lactobacillus acidophilus is present in different parts of the body including intestines, mouth and vagina where it helps protect against harmful bacteria and infection. It may help to protect against coronary heart disease. It may help improve lipid metabolism. However, it does require further evidence to prove these claims. Source
  • Bifidobacterium blend (B. lactis, B. animalis): This probiotic bacterium is found in some dairy products (including breast milk) and may help digestive disorders such as irritable bowel syndrome. Source

Digestive enzyme blend (88mg):

  • Amylase: This enzyme is present in our saliva and helps us digest carbs such as rice and potatoes. Some ingredients, such as Kelp and Garcinia Cambogia, prevent this digestive process and some people believe that doing this stops carbs from being absorbed by the body and turning to fat. Other people believe that digestive enzyme supplements help the body’s digestion and helps weight loss.
  • Bromelain: This natural enzyme is found in pineapple. According to clinical research, it may be effective at helping to reduce pain and inflammation.
  • Lipase: This is a digestive enzyme, which is made in the pancreas and is lacking in some people who suffer from medical conditions, such as celiac or crohns disease. Lipase breaks down, transports fats, and is essential to the digestive process. It may help with digestive issues such as indigestion and gas. Source

Weight Management blend:

  • Green Tea (100mg): Clinical research has found that green tea has proven health benefits, and the antioxidants (EGCG and polyphenols) found to have anti obesity and fat burning properties because of the effects upon the metabolism. Contains caffeine. Source

Craving control blend (166mg):

  • Caralluma Fimbriata: Promising although unproven ingredient for weight loss that may reduce appetite. We covered this native Indian succulent plant in a previous investigation and were impressed. However, it requires further evidence because testing has been very limited. Source

Does Bio X4 Have Any Side Effects?

Everybody is different when it comes to supplements and the way they react to them. Some are as right as rain and others feel side effects within moments of ingesting a product. With Bio X4 healthy people are unlikely to experience serious side effects, but the same cannot be said for those with underlying health conditions or a weakened immune system.

Bio X4 could cause the following side effects:

  • Intestinal gas
  • Bloating
  • Abdominal pains/cramps
  • Nausea
  • Diarrhoea
  • Painful urination
  • Joint pain

If you are particularly sensitive to caffeine which is present in green tea you could experience the following:

  • Jitteriness
  • Sleep disturbances
  • Headaches
Not suitable for individuals under 18. Avoid if you are pregnant or breast-feeding. Ask your doctor before taking this supplement.Probiotics will not be suitable if you have a weakened immune system or certain medical conditions as it may introduce bacteria and infection into your system.This supplement may cause drug interactions so speak to your doctor if you are taking prescription medication.

Are There Any Customer Reviews For Bio X4?

As far as user reviews go we have been unable to locate any reviews on the official site, but we did locate some on Amazon and the findings were interesting. Here are a few of them:

I tried one whole bottle and saw no results at all. No weight loss, no change in digestion, no change in appetite. Only benefit was it encouraged me to drink more water! I purchased directly through Bio-X4 which cost much less than on Amazon. Scam! Wish I could show no stars.

I bought the Bio-x4 from the company’s website – Nucific. I took it diligently for about 3 weeks. I did not experience any positive effects, e.g., of probiotics. However, my sleep became more restless, and I started experiencing some water retention. I’m returning the product back to the company and hope to receive my money back. Don’t waste your time and money on this product!

This company seems strange and perhaps shady. I bought Bio X4 because it sounded all natural; I thought even if I didn’t lose the weight I wanted to lose, the probiotics and green tea extract would still give me benefits. I bought several bottles because every time I went to check out a new, “better” deal would pop up. That should have been a red flag. As someone else already noted, the Google reviews also seem stacked in Nucific’s favor. All of the results are favorable to Nucific, but all are on web pages completely unfamiliar to me. When I ordered the product I thought it was because the product was so new, but months later, the Google results are still like that. I ended up with heartburn that I believe is related to probiotics (I admittedly could be wrong about this but have heard some people get heartburn from certain types of probiotics), so I tried to return the bottles I had not opened. Unfortunately the 90-day grace period was over, so I have lost significant money on my Nucific purchase with nothing noticeably gained on my end. The e-mails from the company are also strange, as are the recipes. Hard to explain but something seems fake or “off” about this company. I would not buy their products again.

Going by these reviews, it seems like Bio X4 does not help with weight loss and it is making people doubt the company.

Does Bio X4 Offer a Money-Back Guatantee?

When it comes to important details, we feel that one of the most important is that a product must have a guarantee so the user feels safe knowing that they won’t lose out if the product doesn’t work in the way they want it to. Nobody likes to be disappointed and realize they lost a lot of money for no reason.

On the site, Nucific offer a full 90-day money back guarantee. Here is what they say:

If you’re not 110% satisfied by the results, send back your order within 90 days for a full refund – no questions asked. You will be absolutely amazed at just how quickly your body can change. See the results for yourself…

Unfortunately it doesn’t specify whether this applies to opened and unopened bottles, so we would suggest contacting them beforehand for confirmation. To claim a refund you need to call 888-679-5520 Monday – Friday from 6am to 8pm, as well as weekends 5am to 5pm.

Where Can I Buy Bio X4?

Nucific Bio X4 is only available from the official site where there are 3 options available for you to choose from.

One bottle (30-day supply) costs $49.00.

Three bottles (90-day supply) costs $129.00.

Six bottles (180-day supply) costs $240.00.

There is free shipping on all orders over $50.

Bio X4 Frequently asked Questions (FAQ)?

What is Bio X4?

Bio X4 is a 4-in-1 probiotic supplement that claims to help you lose weight, to help you take control of your cravings and to enhance your metabolism and digestion.

What are the side effects of Bio X4?

Bio X4 can cause gas, bloating, abdominal pain, nausea, diarrhoea, joint pain, jitteriness, and headaches. If taken too close to bedtime, it may cause insomnia.

What are the ingredients in Bio X4?

Bio X4 contains four proprietary blends known as Probiotic Blend (lactobacillus acidophilus and bifidobacterium), Digestive Enzyme Blend (amylase, bromelain and lipase), Weight Management Blend (green tea extract), and Craving Control Blend (caralluma fimbriata).

Does Bio X4 work?

There is no evidence that probiotics could help with weight loss; the studies and clinical trials are scarce and inconclusive.

How much does Bio X4 cost?

A 30-day supply costs $49.00, a 90-day supply is $129.00, and a 180-day supply is $240.00.

Who makes Bio X4?

Bio X4 is manufactured by Nucific, a company based in California.

How do I take Bio X4?

Take one capsule with a meal, three times a day.

Can I take Bio X4 if I have a health condition?

Avoid if you are pregnant or breast-feeding. Probiotics are not recommended if you have a weakened immune system or certain medical conditions; it is recommended to see a doctor prior to the treatment.

Does Bio X4 have a money-back guarantee?

There is a 90-day money-back guarantee.

How long has Bio X4 been around?

The website only says that Bio X4 is ‘brand new’, but does not precise when it has been put on the market.

Where can I buy Bio X4?

Bio X4 can be bought online from the official Nucific website.

Can I buy Bio X4 in stores?

No, Bio X4 is only available online from the official website.

How do I contact Bio X4 customer service?

You can contact Nucific costumer service seven days a week via email or phone with the details they provide on their website. It is important to remember that their business hours are Pacific Time.

Are there any Bio X4 coupons?

At this time, there are no Bio X4 coupons.

Are there any free samples of Bio X4?

Nucific does not offer free samples for Bio X4.

How does Bio X4 compare to Phentaslim?

CriteriaBio X4 ComparisonPhentaslim comparison
Clinically Proven Ingredients
Side Effect Free
Positive Customer Reviews
24/7 Support
Money-back Guarantee

Disclaimer: Our reviews and investigations are based on extensive research from the information publicly available to us and consumers at the time of first publishing the post. Information is based on our personal opinion and whilst we endeavour to ensure information is up-to-date, manufacturers do from time to time change their products and future research may disagree with our findings. If you feel any of the information is inaccurate, please contact us and we will review the information provided.

220 comments on “Bio X4”

  1. Rose says:

    Hi,I found the BIOX4 presentation very interesting as she seemed to be able to give very good medical reasons for each & every ingredient. However, I’m not convinced it would work & after reading some of the reviews on here I feel even less convinced that it would work. What I would like to know though, is whether I would have been able to use BIOX4 because I am on Warfarin for life as a result of pulmonary emboli. 2 attacks which landed me in A & E twice in the space of a year. I’m not going to buy it as I can’t afford to spare £40 per month; I only just get by as it is but I would like to know if I could have taken it? I would also like to know whether I can safely take Phentaslim? A pharmacist told me that ANYthing I take now will negatively affect my INR so I have to be careful even when it comes to something as innocent sounding as vitamins! So I would every much appreciate your opinion on this?
    Many thanks,
    Rose @~~>~~>~~> (that’s my emoticon for a rose:)

  2. Amir says:

    So I have ordered Bio X4 for a one month supply. So far the product has helped me in many ways. I have more energy, my belly is smaller, and I am regular. For those of you chasing weight loss, I ask you to take a different approach. Your goal should not be weight loss, but should be a better body of health. If you gain some weight that is not necessarily a bad thing. You gain weight because you gain some kind of mass. It doesn’t automatically mean your fatter. You could have gained muscle or internal tissue due to a healthier body. For instance a healed stomachlining can allow your body to repair your stomach tissue adding more mass that was not previously there. I also suggest you use the supplement as instructed. Taking the supplement by itself does not help you. You should be taking with your meal. Your digestive system is looking for resources to fuel your body that the pill doesn’t have. That is why you take it with food, so your body gets what it needs plus an added bonus. Its kind of like tricking your pet take it’s medicine by hiding it in the pet’s food.
    Bio X4 can help you lose unwanted fat by increasing your metabolism. But this will only help you if your using the additional energy by being more active. If your body finds that you do not need the energy, it will store it as fat again. Exercise is great, but if your like me it is hard to keep up that routine. So get a hobby you love that makes you more active. Examples, hiking, biking, paintball, sports, gardening/landscaping, woodwork,automotive work. Pretty much anything that will make you use your body to accomplish a goal. Just get more physical than you normally would.
    Bio X4 may not be a solution for everyone. I suggest you watch the Dr. Lee video completely all the way through, and listen carefully to the information and explainations that are given. This is not a weight loss pill. It is a supplement that addresses digestive system issues that are found commonly in Americans. When these issues are addressed, it “may” lead to weight loss. Remember your goal should not be weight loss, but a healthier body. Not all weight loss is health for your body. When your healthy, you feel good, your body performs like you want it to, and you feel happier.

  3. vida goudarzi says:


  4. Michael Barrett says:

    Ijiust ordered 3 bottles of biox4. I have now received 3 emails showing 3 different orders. Please make sure that you send only the one order that I made,and be sure my credit card is only charged one time.

  5. ellen shubin says:

    I am doing much better with this product, My constipation is not as bad and my stomach pains have gone away. I think BIO-X4 is a great product!!!

  6. ellen shubin says:

    I believe that this product has helped my digestion and my stomach problems.

  7. Leslie Schultz says:

    I think it is a shame a so called “doctor ” is taking advantage of consumers with this scam. Her license should be revoked

  8. Valerie says:

    I took BioX4 for about three weeks and had to discontinue it. I was having major problems with constipation and stomach upset. I went back to my usual probiotic and all of the problems disappeared in about three days. The only meds I take is a thyroid pill and I think it interacted with my thyroid medication because I was very lethargic. That along with the constipation make me quit it and unfortunately I bought a several month supply to try it out but couldn’t even get through one bottle. Do not recommend at all.

  9. vida goudarzi says:

    I ordered 6 bottles of BIO-X4, I am almost done with the third bottle. I am still waiting for at least a pound of weight loss. I start having severe constipation I ADDED MORE FIBER TO MY DIET BY EATING MORE GREENS. THE CONSTIPATION IS BETTER NOW, BUT I AM STILL WAITING FOR SOME WEIGHT LOSS.

  10. David Loman says:

    I bought 3 bottles of the BIO X4 product and saw no results so I gave it the benefit of doubt and bought three more. There was a difference between the first order and the second as it upset my stomach. I called the company and was told someone would get back to me…nothing. I responded to multiple emails sent by Amy Lee but also heard nothing. My wife tried to use the second order and had the same results…upset stomach that lasted all day. Maybe this is their weight loss solution, you feel too sick to eat. I have two full bottles and more than half of the third bottle left so it is obvious we can’t take it. The guarantee offered by the company is worthless as no one will ever get back to you to discuss the problems much less provide a refund. It is another diet scam.

  11. jared higgins says:

    I took a full three month supply of bio x 4 and lost 20 lbs. I have been the same weight my whole life and that was the first time I have seen my abs since highschool. about three months after I quit taking it, I gained the weight back. I am not overweight, just needed to tighten up a little and it worked for me

  12. Mary Ann horrigan says:

    I have a history of seizures. I have searched and have not found any reason why I should not take. Can you tell me if I can take it. I am seizure free for 2 years so I am cautious what I take. Thank you for time and information.
    Mary ann

  13. Barbara Metford says:

    The post Office tried to deliver a package from you, but I wasn’t here. They left me a notice to go to the post office and pick it up with a charge of $10.08. I have rejected this delivery. The post office is sending it back to you as I reject it. DO NOT RESEND

  14. Aslim Rahman says:

    I order three bottles of Bio X4 .So far. I have not received a response as yet. I will like to know when i will receive my supply and which company you be shipping with. Thank you.

  15. Teresa Naron says:

    My digestion issues have improved immensley since taking BioX4. Had slow digestion issues no matter how I ate before taking the product. Now, from meal to meal with supplement, I feel my intake is being digested and stomach emptying out quicker and improved without reflux or indegestion as I experienced for years prior to this supplement. I have appreciated the nutritional uptake improvements. Skin seems improved, as well as olfeelings of overall wellbeing. Most of all the acid reflux belly pain is almost gone. Before even water would trigger acid reflux. I did have gallbladder issue problems for years and now, with this product I have not experienced gallbladder attacks as before. Much improved, overall digestion issues on this supplement with approx.one month supply, so far, I have ingested BioX4 with meals.

    1. Sandy says:

      I was alarmed after reading that WATCH DOG REJECTS BIO-X14. After reading your reply I feel better. The part that BIO-X14 can cause WEIGHT gain is most alarming to my husband, who has 100 lbs. to loose! We will continue for 2 bottles, then see if we will return the other bottles. Phentaslim sounds like the new “diet” pill many are taking. I’m going to carefully monitor the results on this diet pill.

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