The company says that they stick to four fundamental principles, which are applied to all their products. They claim to only use potent ingredients that are supported by clinical studies, the products are quality tested to ensure potency and purity. They are earth friendly, by using renewable energy and recyclable materials, and lastly all their products are made in California. Can Bio X4 live up to the hype?
After going over all the information we have collected it would seem that Nucific Bio X4 may help some people improve their digestive health but there is NO accepted evidence that it will help with weight loss.
If your digestive system is functioning normally, there seems to be no reason to take this supplement.
If you do have digestive problems, you should visit your doctor rather than trust a rather expensive and unproven OTC supplement. Although, the fact that the company is run by trained medical professionals is encouraging, unfortunately there is no sufficient evidence to suggest that this supplement will be safe.
We feel that probiotics need further clinical investigation to prove all the claims that have been made here and eliminate concerns about contamination and safety issues.
There is mounting evidence that certain Lactobacillus probiotics can actually cause weight gain,
Different Lactobacillus species are associated different effects on weight change that are host-specific. Further studies are needed to clarify the role of Lactobacillus species in the human energy harvest and weight regulation. Attention should be drawn to the potential effects of commonly marketed lactobacillus-containing probiotics on weight gain. Source
We like green tea extract for weight loss, as it is included in a lot of products nowadays and has been proven to help with weight loss goals.
One bottle (30-day supply) costs $49.00. Nucific seem to be a reputable company and we love that they offer a guarantee on their products, something a lot of other companies could learn from.
What we weren’t impressed with is the lack of testimonials, on the official site and lack of clinical studies. How many people have actually tried this product and found it to work in the way they state?
While Bio X4 is marketed very slickly, especially with the video marketing featuring Dr Amy Lee, the jury is still out on Probiotics and weight loss. Is it worth taking something that some evidence may cause weight gain? We feel that the best bet, if you want to experiment, is take consume a natural Yoghurt every now and then.
For now, we have no other choice but to reject Bio X4.
With a combination of proven ingredients, superb customer service and a 60-day money-back guarantee, Phentaslim is making big waves in the diet world.
Find out why thousands of people are choosing Phentaslim to achieve their weight loss goals, and why it's also the editor's top selection.
Read the Watchdog Phentaslim review here.
Trying to lose weight can be a tough journey but there are some things than can make it easier, such as eating a healthy diet and exercising regularly. Sometimes a dietary supplement can make all the difference in the world and Bio X4 says that it is designed to help;
Bio X4 contains 4 blended compounds that work together in order to attack weight loss issues. This is perfect for people who would like a supplement that has no lactose, no fillers, uses 100% pure ingredients and vegetarian capsules as well. What’s not to like?
The principle ingredient is the probiotic blend, which is said to contain 4 billion healthy bacteria per capsule, which is a heck of a lot, and is composed of a Lactobacillus blend and a Bifidobacterium blend. Probiotics are important for our health and our bodies could not do without these colonies of the live bacteria and yeasts founds naturally in our bodies. Lactobacillus is a bacteria that is naturally present in the stomach, which produces vitamin K and Lactase (which breaks down Lactose, the sugars in milk products). Bifidobacterium is a type of bacteria present in the colon flora in animals, as well as in the gastrointestinal tract in humans.
Since the mid 1990s, probiotics and supplements containing them have been advertised as a way to benefit the digestion system and help with IBS, eczema, and oral health. However the probiotic supplements and foods do not have any medical backing behind them, which could be a cause for concern.
As well as a probiotic blend, Bio X4 also contains a digestive enzyme blend. Digestive enzymes are present in the body naturally and break down food molecules so that they can be absorbed by the body and taking a supplement including them is said to improve digestion. Bio X4 also contains green tea extract, which is well known for its beneficial effects upon health and weight loss. There is some evidence that suggests green tea can increase the speed of the metabolism, making you lose weight more effectively.
The final ingredient in Bio X4 is Caralluma Fimbriata, a cactus extract that may help cause feelings of satiety to prevent over eating and food cravings.
The manufacturers claim that with Bio X4 you can:
Take control of your appetite again, enhance your metabolism & digestion, and feel better than ever.
The way that each ingredient blend works is explained:
To utilize Bio X4 to the best of it’s ability you have to take 1 capsule with each meal. When taken 3 times daily, an individual receives 12 billion CFU’s. More may be taken as needed. Supplementing each meal with digestive help that assists in processing your food and extracting the maximum amount of nutrients gives your body the tools it requires to operate at its peak level of performance.
When we look back over the facts we don’t see how or why Bio X4 could help you lose weight, as there is no evidence for probiotics and digestive enzyme supplements aiding weight loss. While the Green Tea and Caralluma Fimbriata look promising, the ingredient amounts seem inadequate.
Probiotics for weight loss remain largely untrialled and untested. This form of medical science is in the early stages and nobody knows for sure if probiotics are generally good to take in supplement form. In addition, they are not suitable for everyone as they come with the risk of introducing bacteria into your system.
Not only are the weight loss claims unproven, but also the claims about digestive enzymes are also unproven. We cannot see Nucific Bio X4 doing much for your health or your weight loss.
Nucific Bio X4 is a probiotic supplement that looks to address digestive issues as well as help you lose weight. Serving size is equal to one capsule.
Probiotic blend (4 billion):
Digestive enzyme blend (88mg):
Weight Management blend:
Craving control blend (166mg):
Everybody is different when it comes to supplements and the way they react to them. Some are as right as rain and others feel side effects within moments of ingesting a product. With Bio X4 healthy people are unlikely to experience serious side effects, but the same cannot be said for those with underlying health conditions or a weakened immune system.
Bio X4 could cause the following side effects:
If you are particularly sensitive to caffeine which is present in green tea you could experience the following:
As far as user reviews go we have been unable to locate any reviews on the official site, but we did locate some on Amazon and the findings were interesting. Here are a few of them:
I tried one whole bottle and saw no results at all. No weight loss, no change in digestion, no change in appetite. Only benefit was it encouraged me to drink more water! I purchased directly through Bio-X4 which cost much less than on Amazon. Scam! Wish I could show no stars.
I bought the Bio-x4 from the company’s website – Nucific. I took it diligently for about 3 weeks. I did not experience any positive effects, e.g., of probiotics. However, my sleep became more restless, and I started experiencing some water retention. I’m returning the product back to the company and hope to receive my money back. Don’t waste your time and money on this product!
This company seems strange and perhaps shady. I bought Bio X4 because it sounded all natural; I thought even if I didn’t lose the weight I wanted to lose, the probiotics and green tea extract would still give me benefits. I bought several bottles because every time I went to check out a new, “better” deal would pop up. That should have been a red flag. As someone else already noted, the Google reviews also seem stacked in Nucific’s favor. All of the results are favorable to Nucific, but all are on web pages completely unfamiliar to me. When I ordered the product I thought it was because the product was so new, but months later, the Google results are still like that. I ended up with heartburn that I believe is related to probiotics (I admittedly could be wrong about this but have heard some people get heartburn from certain types of probiotics), so I tried to return the bottles I had not opened. Unfortunately the 90-day grace period was over, so I have lost significant money on my Nucific purchase with nothing noticeably gained on my end. The e-mails from the company are also strange, as are the recipes. Hard to explain but something seems fake or “off” about this company. I would not buy their products again.
Going by these reviews, it seems like Bio X4 does not help with weight loss and it is making people doubt the company.
When it comes to important details, we feel that one of the most important is that a product must have a guarantee so the user feels safe knowing that they won’t lose out if the product doesn’t work in the way they want it to. Nobody likes to be disappointed and realize they lost a lot of money for no reason.
On the site, Nucific offer a full 90-day money back guarantee. Here is what they say:
If you’re not 110% satisfied by the results, send back your order within 90 days for a full refund – no questions asked. You will be absolutely amazed at just how quickly your body can change. See the results for yourself…
Unfortunately it doesn’t specify whether this applies to opened and unopened bottles, so we would suggest contacting them beforehand for confirmation. To claim a refund you need to call 888-679-5520 Monday – Friday from 6am to 8pm, as well as weekends 5am to 5pm.
Nucific Bio X4 is only available from the official site where there are 3 options available for you to choose from.
One bottle (30-day supply) costs $49.00.
Three bottles (90-day supply) costs $129.00.
Six bottles (180-day supply) costs $240.00.
There is free shipping on all orders over $50.
Bio X4 is a 4-in-1 probiotic supplement that claims to help you lose weight, to help you take control of your cravings and to enhance your metabolism and digestion.
Bio X4 can cause gas, bloating, abdominal pain, nausea, diarrhoea, joint pain, jitteriness, and headaches. If taken too close to bedtime, it may cause insomnia.
Bio X4 contains four proprietary blends known as Probiotic Blend (lactobacillus acidophilus and bifidobacterium), Digestive Enzyme Blend (amylase, bromelain and lipase), Weight Management Blend (green tea extract), and Craving Control Blend (caralluma fimbriata).
There is no evidence that probiotics could help with weight loss; the studies and clinical trials are scarce and inconclusive.
A 30-day supply costs $49.00, a 90-day supply is $129.00, and a 180-day supply is $240.00.
Bio X4 is manufactured by Nucific, a company based in California.
Take one capsule with a meal, three times a day.
Avoid if you are pregnant or breast-feeding. Probiotics are not recommended if you have a weakened immune system or certain medical conditions; it is recommended to see a doctor prior to the treatment.
There is a 90-day money-back guarantee.
The website only says that Bio X4 is ‘brand new’, but does not precise when it has been put on the market.
Bio X4 can be bought online from the official Nucific website.
No, Bio X4 is only available online from the official website.
You can contact Nucific costumer service seven days a week via email or phone with the details they provide on their website. It is important to remember that their business hours are Pacific Time.
At this time, there are no Bio X4 coupons.
Nucific does not offer free samples for Bio X4.
| Criteria |  |  |
|---|---|---|
| Clinically Proven Ingredients | ||
| Side Effect Free | ||
| Positive Customer Reviews | ||
| 24/7 Support | ||
| Money-back Guarantee | ||
| FREE SHIPPING | ||
| Review | Phentaslim Review |
Summary
Diet Pills Watchdog does not recommend Bio X4.
Disclaimer: Our reviews and investigations are based on extensive research from the information publicly available to us and consumers at the time of first publishing the post. Information is based on our personal opinion and whilst we endeavour to ensure information is up-to-date, manufacturers do from time to time change their products and future research may disagree with our findings. If you feel any of the information is inaccurate, please contact us and we will review the information provided.
Be nice. Keep it clean. Stay on topic. Please do not spam.
I do not recommend Bio.X4. I went to emergency room because of it. It caused horrible lower abdominal pain, and cost me far more paying hospital bills. It seems that it does not work with everyone, if it works at all. Certainly I did not loose one pound, it did not help with anything they claimed that it does help. I wish I can get a refund for it so expensive
I tried Bio X4 for 30 days. I am in the process of trying to get a refund. I suffered with extreme constipation and DID NOT loose any weight. I gained weight!!! Very disappointed and feel that the video on line is deceiving.
If you were constipated, it has nothing to do with enzymes, probiotic or green tea. You probably are dehydrated and not eating enough fats. The ingrediaents in biox4 are very basic and can be bought individually. Digestive enzymes and probuotics are recommended by all nutritionists. Weight gain is probably from stool build up and you probably didnt heed a good diet. Your commments show you are uneducated in nutrituon. See your doctor. He will recommend all the same ingredients in Bio x4 for good for health. You will NOT ever lose weight if your gut is unhealthy. Being constipated says your gut is unhealthy.
you were very rude in your reply and I have read the later comments and others seem to have had the same response from the Bio x4. Did you try the product yourself that would leave you to tell this person that they didn’t feel that way because of the supplement?
Though I can appreciate this website taking the time to “evaluate’ products, the issue for me is lack of information balance in your product promotion of Phentaslim over Bio X4. Both products contains essentially the same ingredients as. So how is it that you can make the claim that Phentaslim has no side effects and Bio X4 does, and how Phentaslim has clinically proven ingredients when Bio X4 doesn’t when Bio X4 has the same ingredients as Phentaslim? Additionally, by virtue of the fact the both products contain the same ingredients inclusive of lactobacillus, the claim of “NO accepted evidence that it will help with weight loss” would therefore be the same for Phentaslim.
Where do I return the placebo pills called BIO X4. They are useless for losing weight. What a scam.
I have IBS with constipation will this help with the effects of IBS – regular pain in my left side, everything I eat either goes straight through me or causes constipation. I was told I should take BIO-X4.
DO NOT deal with this company, they are crooks going after your money. They sent me the product even though I requested the order to be cancelled! You can see from the ordering process they are deceptive, trying to trick you into buying more. You never see a order confirmation to make changes before the final order goes through! Customer service will not resolve your problems. I have dealt with a great deal of different companies, but NONE of them is anything like Nucific. The owner is a doctor named Amy Lee from Hong Kong. What a disgrace she is! she should change her name to Amy Lie!
Hi, Angel, I had the same experience with them. I tried to get my money back but they told me they never received the product I sent to them, I think it is a scam also. I felt terrible after using BioX.4
CW
If information is based on your personal opinion then how can it possibly be true facts?
Are these facts on this product accurate or true? How can I trust that what you are saying is true. Why does this product create those side effects and why does the Bio x4 website claim that there is no side effects, but this website is giving these side effects? Also you do not take with your meal, you take it 30 minutes before eating so that you give it time to break down into your digestive system so it can properly work. How did you conclude to take it with your meal? Last question. Those reviews, where can I find those reviews from people? The actual reviews that you posted on this site.
Just using google i found at least 3 double blind plecebo studies showing that the enzymes help with weight loss and pro biotics help with digestion which in turn helps with weight loss. I think you should do some research before you tell people there is no proof of something working. Shame.
thank you watch dog I really appreciate your info on Bio-x4 I think I’m going to pass
Just watched the video and was impressed, but I’m obedient to my discernment and decided to check. Think I will pass on the Bio X4.
I haven’t noticed any weigh-loss, but I do have painful urination and extreme joint pain. I have been to my doctor for the UTI and taken antibiotics. While on the antibiotics, I stopped taking Bio-X4 while on medication, and the problem cleared up. When I finished the antibiotic, I resumed the Bio-x4 and the pain returned. Also, the strongest leg cramps I have ever experienced happened, and I have tremendous pain in my right shoulder, so much so that my doctor thought I had torn the rotator cuff. I cannot recommend this product to anyone.
I am trying to return my bottles, I to have not lost any weight in fact I put on weight and was not very happy !!!! I am looking to get my money back.This product is not what I had hoped it would be, and I should have know better than to try it.
I also have found weight gain and am really upset by this! I’ve requested a refund for my purchase as well. Definitely didn’t help with weight loss and did the opposite. I’m a runner – am training for a marathon – running 5-10 miles a day 3x a week right now – and I’m GAINING WEIGHT? Something very wrong with this picture. Don’t waste your money on this product.
I watched the Nucific video this morning with Dr. Lee. I was impressed and almost yielded to temptation but did not!!! I decided to do some checking and I am so glad that I came across your website. It actually saved me $130.00 that I was seriously thinking about spending on these so called healthy pills from Dr. Lee. If they did all that they say, it would be worth it but I just cannot afford to take a chance on something that won’t help me. I was looking for something that would help me to feel better, not necessarily for weight loss. Yes, I could certainly afford to lose a few pounds but that isn’t what I wanted in these supplements. I wanted to feel more healthy and energetic. I have severe pain drug induced constipation and I was hoping that just maybe these pills would help that situation. But now I have learned that these supplements could help cause constipation, gas, and bloating of which I have enough of the way I am.
Thank you for telling us about Nucific. Maybe when they have a few thousand testimonials saying that it really helps I will reconsider my purchase.
Thank you for your research,
Joanie from NW Indiana USA
Try taking magnesium for pain med induced constipation. I take 400 mg daily and will take a second 400 mg if I have eaten things I know will encourage constipation (like cheese, chocolate, etc.). You may have foods you know cause you problems. Also DSS helps without giving diarrhea. Common item at drug store.
Good luck.
Hi Joanie, I read your review because I was doing my due diligence to decide if I should try the Bio X4. I noticed that you mentioned that you have bad constipation, I used to suffer with that also but I now use Poop Doc formula 1, which I have been using for 2 years and It is a miracle worker. Google Poop Doc and see for yourself. This product is phenomenal. I’m only passing this info on to you because of my past experiences with constipation and I was blessed to find this. Just passing it forward to help another human being. I gain nothing from it other then helping others. If you decide to check them out ask for Scott the owner of Poop Doc, a down to earth and very knowledgeable person who personally talks to his customers. Good luck with feeling better. Frank L from NY
Dear Joanie,
I’m so sorry to hear that your suffering from Pain Medicine induces constipation. I too have suffered greatly from that. Please, if you can, start weaning yourself off of the medicine. I know you don’t know me, but I have suffered from pain for over 20 years and have taken medicine, including; Vicodin, Norco, and lastly Tramadol for about 13 years. I have been weaning myself off of the medicine for about a year now and although I’m still in pain, the medicine has it’s own side effects you should seriously know about. I came on this site because when your in pain your first thought is quality of life. Mine is limited. Now, I not only suffer from the pain I have had for such a long time but now I suffer from pain induced from the medicine. I have never been effected mentally from the medicine accept about 5 years ago the left side of my head went numb but it went away. Now…after having setbacks physically, I had to take a bit more medicine than normal but not the full monthly prescription. I was still taking less but now I have had to completely quit. you see, after all these years the medicine started making my right thigh go numb. Now it is numb all the time and although it was a fairly small area on the top of my thigh, it has reached down the side to the back and is extremely painful because now it has a serious burn feeling. I have had to literally pull my pants away from my leg to stop the pain I had from just contact with anything rubbing against my thigh.
I don’t plan on taking this Bio-x4 but your note moved me because I pray that whoever reads this will stop taking pain medicine. The side effects from my pain medicine has been worse than my daily pain and that says a lot. God Bless you and I hope you can find what you need. Take care.
Joanie, I forgot to tell you this too. Please drink as much water as you can. I drink at least 8 to 10 glasses a day….still! I have had to drink water all through the night because the medicine for pain dehydrates you substantially and will also effect the inside of your stomach and your intestines. Don’t be surprised if you end up with tears on your anal wall. If you have bleeding don’t be surprised if the doctor tells you that it’s internal too. I’m sincerely not trying to grose you out but I have sincerely suffered because the doctor’s don’t always tell you the additional side effects because they don’t know! You have to be, everyone has to be they’re own advocate when they go to the doctor’s. Even when I haven’t taken medicine for a month I’m still dehydrated. I have lost 15 lbs by making small changes and my overall health has improved a bit with the changes. Take baby steps and sincerely look for ways to help yourself feel better. I really know, really know, what to do to improve my health. Knowing it and doing it are two completely different things. Take care.
Hi Joannie and other repliers to her, I was taking pain relief after a hip replacement which caused severe constipation. I was then told to take Movicol and Sennacot to address this and after no effect, requested 2 enemas. None of the above worked as well as the advice of my New Zealand friend. She said eat kiwi fruit with their skins on! What a miracle! I ate two each day for 48 hours and the results were fantastic. After this I ate just one a day as two felt too strong, until I came off the pain killers. I still eat them with the skin on now if I get constipated or occasionally without if I have no digestive problems. Sounds horrible? Just slice them and you don’t really notice the hairy skin! What a pity every doctor isn’t aware of this. Think of how much money we could save and more importantly, you’re eating a natural food, not taking another drug. I don’t know if this works for everyone but lots of people in NZ use this method. Try it and see.
I took Bio X-4 for 2 months. It didn’t work for me, even with other lifestyle changes. I didn’t lose any weight, and suffered from gas and constipation. I rated the product poorly when they sent me a survey, and promptly received a phone call urging me to be patient and persist. I saw no point in carrying on, and returned the remaining bottles. To my surprise, despite their much-touted total satisfaction guarantee, I only received credit for the return, not the entire order. So if you order 3 months’ supply, and persist as recommended, you won’t get any refund… I entered a “disputed charge” claim with my credit card company, and received a full refund from Nucific. But in their email to me Nucific said “Our apologies for any miscommunication in regards to our return policy, we refund for the bottles returned to us. But we are willing to make an exception.” The bottom line is: don’t trust their warranty, and be prepared to make a fuss.