Contrave

If you’re serious about weight loss, you may be tempted to explore the most reputable and trustworthy products to assist you on your journey. Many would argue that you can’t do much better than an FDA-approved, prescription drug backed by multiple clinical trials. After all, why take supplements from mysterious companies on the Internet when you can get a prescription from your local doctor?

Below we take an in-depth into one such drug called Contrave, to see whether these strong scientific foundations help users to shift the pounds.

Contrave Pros

  • Customer feedback on some websites is broadly positive
  • FDA approved
  • May be covered on some health insurance policies

Contrave Cons

  • Has numerous side effects
  • Studies show that the drug is ineffective for the majority of users
  • Impossible to return or receive money-back guarantee
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Contrave

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What You Need To Know About Contrave

Contrave is an FDA-approved, prescription-only drug that contains two active ingredients. Both ingredients work in conjunction to reduce food cravings, helping users that are already committed to a program of diet and exercise to lose weight.

Contrave is only available in the USA, and interested users must first visit their local doctor in order to receive a prescription. This process is very important, as Contrave has a number of serious side effects that could become more extreme under certain circumstances.

What Are The Side Effects Of Contrave?

Before taking Contrave, we highly recommend having a long conversation with your doctor. This weight loss solution is not for everyone!

Taking Contrave comes with a number of side effects that seem to affect almost all users. The most commonly reported side effects of taking Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhoea. Serious side effects like these have caused a number of problems for Contrave’s manufacturers and user base over the years; in one early trial, 62% of users stopped using the drug early due to at least one of these side effects.

There are a number of other less-common side effects that are considerably more dangerous. Taking Contrave carries the risk of seizures, severe allergic reactions (including rash, itching, hives, fever, swollen lymph glands, painful sores in the mouth or around the eyes, swelling of the lips or tongue, chest pain, or trouble breathing), increase in blood pressure or heart rate, liver damage, hepatitis, manic episodes, and visual problems.

It is extremely important that you tell your doctor your entire medical history before taking Contrave. Opioid users (from prescription pain pill users to heroin addicts) may suffer a withdrawal or overdose whilst taking Contrave, and diabetics could experience hypoglycemia as a side effect.

How Much Does Contrave Cost?

As a prescription drug, the cost of Contrave varies hugely depending on your location or insurance provider. The cheapest option appears to be using the Contrave Savings Card, which can be ordered on the official website. Users of the Contrave Savings Card pay just $30 a month, with other users (or their insurance companies) paying $200 or more per month. Before arranging any prescription, we invite all American readers to check the terms of their health insurance to see whether a weight loss treatment like Contrave is covered.

Our Verdict On Contrave

Contrave will certainly work for some users, as shown by its vocal community of supporters on the forums of www.drugs.com and comments sections around the Internet. If someone is committed to weight loss through proper diet and exercise, they could get the extra push they need from Contrave, which seemingly can reduce cravings as promised.

That being said, there is so much about this drug to dislike. The side effects listed for Contrave are legendary, and extremely common. Users report vomiting, headaches, nausea and dizziness on a regular basis, with even its defendants mentioning that they had to break through a “pain barrier” to see success with it. We insist that all users have a long and thorough conversation with their doctor before taking Contrave, as there is still a long list of people who could suffer serious harm from taking the drug, including those with mental illnesses, those with heart problems, diabetics, or those suffering with an addiction to drugs or alcohol.

The studies that back Contrave up also condemn it in our eyes. A discontinued initial study showed that 62% of users stopped taking Contrave due to its hideous side effects, and later studies showed that 58% failed to lose a significant amount of weight after more than a year of taking it. For all the various ailments it promises, it cannot even guarantee weight loss to the committed.

A look into the history of these studies and Contrave’s subsequent approval by the FDA gives the whole saga an air of scandal. Records show that the initial study was discontinued because the results were compromised by the manufacturer, Orexigen Therapeutics, breaking confidentiality and publicly claiming successful results before the study had even finished, including making untrue claims that the drug could help to treat heart disease. It is a mystery to us why the drug was approved given this murky bit of interference, the oddly poor study results that eventually emerged, and the numerous side effects associated with taking it. The head of the FDA’s Office of New Drugs, John Jenkins MD, has even claimed that the studies that led to Contrave’s approval were “highly unreliable” and “misleading”.

For these reasons, we do not recommend this product, and strongly advise all readers to discuss it thoroughly with their doctor before considering it.

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Contrave Review

Contrave is a prescription-only weight loss drug that aims to act as a medical solution for obesity. Containing two key active ingredients, Contrave works by combining two drugs that were designed to deal with addictive cravings. The resulting mix was approved by the FDA in 2014, although this process and the results of the studies that underlined it have remained controversial to this day.

Contrave Facts

  • Contains 70 tablets per box
  • Manufactured by Orexigen Therapeutics Inc.
  • Only available through prescription

Contrave is manufactured by Orexigen Therapeutics Inc. and can be acquired from their website (pending a prescription from your doctor). Other rebranded versions of Contrave (such as the emerging drug Mysimba in the UK) may soon be available outside of the USA following approval from the relevant governing bodies.

How to Take Contrave

Start by slowly increasing your dose over time to help you adjust to treatment. Begin with one morning tablet during your first week, and then gradually work up to two tablets twice a day by week four. Remember to always take Contrave exactly as your doctor prescribes. Remember that some people, like those with renal or hepatic impairment, or those taking other medications, may need to follow a different dosing schedule.

Orexigen Therapeutics have provided their contact details on the Contrave official website: https://contrave.com/contact-us/

Contrave Concerns:

  • Extremely expensive weight loss solution for many users
  • Comes with a range of serious side effects
  • Studies have found that the majority of users fail to lose much weight

What Does Contrave Claim To Do?

On the official Contrave website, the manufacturers claim that the drug can be prescribed as a weight loss solution. The formula works in quite a distinctive way; to quote the website:

FDA-approved, prescription-only CONTRAVE contains two medicines, bupropion and naltrexone. These well-known drugs have been prescribed separately for years—bupropion for depression and smoking cessation, and naltrexone for alcohol and opioid dependence. CONTRAVE combines these medicines and is believed to work on two areas of your brain—the hunger center and the reward system—to reduce hunger and help control cravings.

Does Contrave Work?

Unlike most of the diet pills we review, we are fortunate to have access to a large and useful bank of data related to Contrave and its chances of success. In fact, the manufacturers would have had to have conducted these studies in order for Contrave to be approved by the FDA and become the prescription drug it is today. It remains odd to us then that many of the available studies do not signal particularly encouraging success rates.

In three long-term studies, 2332 obese or overweight participants were invited to take either Contrave or a placebo. After just over a year of taking their assigned pill, it was found that 46% of Contrave patients had lost 5% or more of their body weight (meaning that over half failed to lose much or any weight at all). It was also found that on average, the users taking Contrave generally lost just 5-9 pounds more than those taking the placebo. In another concerning study that was discontinued by the FDA, it was found that 62% of users simply stopped taking their Contrave pill early due to its many side effects.

In short, Contrave evidently works for some users, but many, many others will give up due to unpleasant side effects, or will fail to lose weight regardless.

What Are The Ingredients of Contrave?

The ingredients used in Contrave are listed below. The formula contains a mix of just 2 pre-existing drugs that work in conjunction to reduce food cravings.

  • Naltrexone Hydrochloride 8mg: Naltrexone is sometimes used as part of a medical plan to manage alcohol dependency by reducing cravings.
    Source: https://www.drugs.com/pro/naltrexone.html
  • Bupropion Hydrochloride 90mg: This drug has been used to treat depression and seasonal affective disorder. Like Naltrexone, it can also be used to help reduce cravings, and has been included in other products that claim to help people quit smoking.
    Source: https://www.drugs.com/bupropion.html

Does Contrave Have Any Side Effects?

Despite its prescription status, Contrave is hugely let down by its many extreme side effects. It may be one of the most problematic weight loss solutions we’ve seen for this reason.

The most commonly reported side effects of taking Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhoea. These side effects seem to affect the overwhelming majority of users: one early trial found that 62% of users stopped using the drug early, with almost all citing at least one of these side effects as a reason.

There are a number of other less-common side effects that are considerably more dangerous. Taking Contrave carries the risk of seizures, severe allergic reactions (including rash, itching, hives, fever, swollen lymph glands, painful sores in the mouth or around the eyes, swelling of the lips or tongue, chest pain, or trouble breathing), increase in blood pressure or heart rate, liver damage, hepatitis, manic episodes, and visual problems.

It is extremely important that you tell your doctor your entire medical history before taking Contrave. Opioid users (from prescription pain pill users to heroin addicts) may suffer a withdrawal or overdose whilst taking Contrave, and diabetics could experience hypoglycemia as a side effect.

Caution:
One of the ingredients in CONTRAVE, bupropion, may increase the risk of suicidal thinking in children, adolescents, and young adults. CONTRAVE patients should be monitored for suicidal thoughts and behaviors. In patients taking bupropion for smoking cessation, serious neuropsychiatric events have been reported. CONTRAVE is not approved for use in children under the age of 18.

Do not take CONTRAVE if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion such as WELLBUTRIN, APLENZIN or ZYBAN; have or have had an eating disorder; are dependent on opioid pain medicines or use medicines to help stop taking opioids such as methadone or buprenorphine, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking; are allergic to any of the ingredients in CONTRAVE; or are pregnant or planning to become pregnant.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider says it is okay. Tell your healthcare provider about all of your medical conditions before taking CONTRAVE.

Are There Any Customer Reviews For Contrave?

As Contrave is not available on Amazon (our usual source of customer reviews), we have taken some user comments from www.drugs.com. Feedback is broadly positive, with some exceptions.

I been on this medicine for 2 1/2 months and have lost 26.5 pounds so far. I can’t eat on this medicine. After a few bites I feel stuffed. It works great for me, and I have tried every thing out in the past 10 years. The only side effects are dry mouth and lower back pain. Well worth the trade-off.

I been on Contrave for 3 1/2 months. I have lost 60lbs. I have changed my eating habits. Workout every night. I highly recommend this medicine.

I’m a nurse and know all about package inserts explaining side effects but man they weren’t kidding. I was started about 3 weeks ago by my doctor who said I needed to lose a bunch of weight. I expected some stomach upset but not like this. Now I understand why the slow titration to higher more effective dosing. I can’t bear the side effects. I cannot work with stomach upset all day and need to rest at night. Back to diet and exercise for me. This is just not right.

When I started to take Contrave, the first 3 days I felt a little jittery but nothing I couldn’t handle. I felt I had tons of energy and my appetite was supressed right away. But on day 4, I was so sick that I couldn’t get out of bed. If I stood up, the room would spin and I was vomiting all day long that day. I couldn’t stop vomiting for at least 30 minutes. Needless to say, I never took it again. So I paid $70 for this bottle for nothing. I only took 4 pills because I was only taking the morning dose.

Does Contrave Offer a Money-Back Guarantee?

As Contrave is a prescription drug, no returns are permitted for it. The manufacturers list no money-back guarantee arrangement on the official website.

Where Can I Buy Contrave?

Contrave can be purchased following prescription from your doctor, who will be able to take you through the procedure. Oddly enough, customers in some states can also purchase Contrave directly from the website after filling out an online form and undertaking a “video consultation” with a doctor online. Needless to say, we find this process shady and not particularly responsible, especially when factoring in Contrave’s numerous side effects and risks. Contrave is only available in the USA (although other rebranded products may soon be available in Europe).

Prices vary hugely for Contrave depending on your circumstances, ranging from $30 to around $200 per month. The cheapest option appears to be using the Contrave Savings Card, which can be ordered on the official website. Before arranging any prescription, we invite all American readers to check the terms of their health insurance to see whether a weight loss treatment like Contrave is covered.

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Disclaimer: Our reviews and investigations are based on extensive research from the information publicly available to us and consumers at the time of first publishing the post. Information is based on our personal opinion and whilst we endeavour to ensure information is up-to-date, manufacturers do from time to time change their products and future research may disagree with our findings. If you feel any of the information is inaccurate, please contact us and we will review the information provided.

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