Does Inulin Really Contribute to Loss of Body-weight?

Fermentable carbohydrates like inulin, guar gum and fructo-oligosaccharides – amongst others – sufficiently alter intestinal microbial flora to significantly retard the development of obesity.

InulinLet us have a look at these fermentable carbohydrates; inulin in particular.

Altered gut microbial flora is increasingly being suggested as an important contributor to increase in fat mass leading to obesity (Backhed et al., 2004). This is true both in animals (Ley et al., 2005) and human beings (Ley, Turnbaugh, Klein, & Gordon, 2006).

“Fermentable” carbohydrates like inulin, guar gum and fructo-oligosaccharides – amongst others – sufficiently alter intestinal microbial flora to significantly retard the development of obesity.

Let us have a look at these fermentable carbohydrates; inulin in particular.

How does Inulin Supplementation lead to fat loss?

Fermentable carbohydrates like inulin (also, fructans and ?-glucan) – as their name suggests – undergo fermentation in the large intestine (Kleessen, Hartmann, & Blaut, 2001; Snart et al., 2006). Others like guar-gum and fructo-oligosaccharides improve the large gut micro flora by increasing the bifidobacteria and lactobacilli (Tuohy, Kolida, Lustenberger, & Gibson, 2001).

Synonyms frequently used for inulin are chicory root fiber or chicory root extract. Although, large-scale “industrial” production comes from chicory roots, inulin occurs in a wide variety of plants and has been a part of the human diet since time immemorial. Chemically, it is composed of a mix of linearly arranged oligofructose and polyfructose chains terminating in a glucose molecule (Sensus, 2013).

All of these fermentable carbs – by effectively improving the population of the beneficial colon bacteria – cause reduction in body weight by either increasing anorectic (hunger-suppressing) hormones or by inducing satiety (hunger-quenching) (Cani, Neyrinck, Maton, & Delzenne, 2005; Zhou et al., 2006; Zhou et al., 2008):

  • Increase in peptide YY (Cani et al., 2005; Parnell & Reimer, 2009)
  • Increase in glucagon like peptide-1 (GLP-1) (Cani et al., 2005)
  • Suppression of plasma ghrelin levels (Arora et al., 2012)
  • Induction of satiety (Vitaglione, Lumaga, Stanzione, Scalfi, & Fogliano, 2009; Kaji, Karaki, Tanaka, & Kuwahara, 2011)

Also, oligofructose-enriched inulin delays progression of obesity even when high fat diets are consumed regularly (Arora et al., 2012). When supplemented with inulin, both visceral and subcutaneous fat in male mice decreased significantly. Furthermore, adipocyte (fat cell) size was also shown to have been reduced (Arora et al., 2012).

Other studies have also reported similar findings even when high-fat diets have been consumed (Cani et al., 2005; Cani, Dewever, & Delzenne, 2004).

Dosage and Adverse effects associated with Inulin

As with other dietary fibers, lack of research means the doses for inulin supplementation have not been standardized.

Similarly, the side-effects or adverse-effects profile of inulin has also not been defined. However, some untoward effects that may occur, especially in those with sensitivity are:

  • Intestinal upset – including bloating and gases
  • Diarrhoea
  • Increase in harmful intestinal micro flora
  • Rarely, an anaphylactic reaction due to “food allergy reactions” may be encountered

Our Verdict on Inulin for Weight Loss

Although the effectiveness of inulin in causing weight-loss has been proven, it can be argued that much of the evidence comes from animal studies. Having said that, the suggested mechanisms (of inulin and other fermentable carbohydrates) to reduce adipose tissue do seem convincing.

Diet Pills Watchdog recommends the use of inulin as a dietary supplement. However, (given that there is lack of human evidence), it may or may not induce weight-loss.

References

  • Arora, T., Loo, R. L., Anastasovska, J., Gibson, G. R., Tuohy, K. M., Sharma, R. K. et al. (2012). Differential effects of two fermentable carbohydrates on central appetite regulation and body composition. PLoS One, 7, e43263.
  • Backhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A. et al. (2004). The gut microbiota as an environmental factor that regulates fat storage. Proc.Natl.Acad.Sci.U.S.A, 101, 15718-15723.
  • Cani, P. D., Dewever, C., & Delzenne, N. M. (2004). Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats. Br.J Nutr., 92, 521-526.
  • Cani, P. D., Neyrinck, A. M., Maton, N., & Delzenne, N. M. (2005). Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like Peptide-1. Obes Res., 13, 1000-1007.
  • Kaji, I., Karaki, S., Tanaka, R., & Kuwahara, A. (2011). Density distribution of free fatty acid receptor 2 (FFA2)-expressing and GLP-1-producing enteroendocrine L cells in human and rat lower intestine, and increased cell numbers after ingestion of fructo-oligosaccharide. J Mol.Histol., 42, 27-38.
  • Kleessen, B., Hartmann, L., & Blaut, M. (2001). Oligofructose and long-chain inulin: influence on the gut microbial ecology of rats associated with a human faecal flora. Br.J Nutr., 86, 291-300.
  • Ley, R. E., Backhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) Obesity alters gut microbial ecology. Proc.Natl.Acad.Sci.U.S.A, 102, 11070-11075.
  • Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006). Microbial ecology: human gut microbes associated with obesity. Nature, 444, 1022-1023.
  • Parnell, J. A. & Reimer, R. A. (2009). Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. Am J Clin Nutr., 89, 1751-1759.
  • Sensus. (2013). What is inulin
  • Snart, J., Bibiloni, R., Grayson, T., Lay, C., Zhang, H., Allison, G. E. et al. (2006). Supplementation of the diet with high-viscosity beta-glucan results in enrichment for lactobacilli in the rat cecum. Appl.Environ.Microbiol., 72, 1925-1931.
  • Tuohy, K. M., Kolida, S., Lustenberger, A. M., & Gibson, G. R. (2001). The prebiotic effects of biscuits containing partially hydrolysed guar gum and fructo-oligosaccharides–a human volunteer study. Br.J Nutr., 86, 341-348.
  • Vitaglione, P., Lumaga, R. B., Stanzione, A., Scalfi, L., & Fogliano, V. (2009). beta-Glucan-enriched bread reduces energy intake and modifies plasma ghrelin and peptide YY concentrations in the short term. Appetite, 53, 338-344.
  • Zhou, J., Hegsted, M., McCutcheon, K. L., Keenan, M. J., Xi, X., Raggio, A. M. et al. (2006). Peptide YY and proglucagon mRNA expression patterns and regulation in the gut. Obesity (Silver.Spring), 14, 683-689.
  • Zhou, J., Martin, R. J., Tulley, R. T., Raggio, A. M., McCutcheon, K. L., Shen, L. et al. (2008). Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents. Am J Physiol Endocrinol.Metab, 295, E1160-E1166.

Disclaimer: Our reviews and investigations are based on extensive research from the information publicly available to us and consumers at the time of first publishing the post. Information is based on our personal opinion and whilst we endeavour to ensure information is up-to-date, manufacturers do from time to time change their products and future research may disagree with our findings. If you feel any of the information is inaccurate, please contact us and we will review the information provided.



2 comments on “Does Inulin Really Contribute to Loss of Body-weight?”

  1. Jennifer says:

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  2. Jennifer says:

    Thinking of buying Probiotic Svelte to lose weight. Anyone heard of/ tried them? They ‘re not expensive but I don “t have money to spend on products that don”t work

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