ISDG Night Enzyme

ISDG Night Enzyme is a supplement that claims to improve digestion, as well as accelerate the metabolism, improve body shaping, and weight loss while you sleep. We find out more.

ISDG is a Japanese brand made for the Japanese market which has found its way to the West. The packaging and most of the product information is in Japanese. ISDG stands for Ishokodogan which means “food and medicine from the same source”, and is the full name of the company. ISDG supplements are sold via Amazon.

ISDG Night Enzyme Pros

  • According to feedback, it may help digestive issues

ISDG Night Enzyme Cons

  • Inadequate ingredients information
  • Effects could be unpredictable
  • Very little product information
Watchdog Rejected

ISDG Night Enzyme

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ISDG Night Enzyme Overview

What You Need To Know About ISDG Night Enzyme

ISDG Night Enzyme is a Japanese supplement that is now available to the American market. Unfortunately, this has not included translating the ingredients list into English and despite all the claims made by the advertising, it is hard to find any real information about it.

Each package contains 120 capsules which are equivalent to a month’s supply – you take four pills daily before bedtime and the idea is that you stay on this supplement for months rather than weeks, in order to experience digestive benefits. There is an advertised money-back guarantee but with no further details such as a contact phone number or email, it may be hard claiming a refund if you are dissatisfied.

What Are The Side Effects Of ISDG Night Enzyme?

Potential side effects may include digestive issues such as bloating, gas, abdominal discomfort, diarrhoea, and constipation.

With the high number of ingredients, many of them unknown to consumers in the West, there may be a risk of an allergic reaction. Symptoms of an allergic reaction include swelling hives, breathing problems, or a high temperature. In the case of an allergic reaction, seek medical advice immediately.

How Much Does ISDG Night Enzyme Cost?

ISDG Night Enzyme is not overly expensive. Buy from Amazon USA and it costs $19.37 for 120 pills (30 days supply).

Our Verdict On ISDG Night Enzyme

The problem with ISDG Night Enzyme is that there is no real proof it will work as described. The huge ingredients list of fruit and vegetable enzymes sounds as if it should be good for health, but there is no real evidence that it will work as claimed. In addition, with such inadequate ingredients information, it is impossible to see just what you are taking.

We do like the amino acid content, even though there may be an unnamed component, because L Lysine, L Arginine, and L Ornithine have undergone research in Japan and may help improve sleep and stress levels. However, without knowing the ingredient quantities in the supplement, it is impossible to know whether they conform to clinical testing.

In our opinion, the company behind ISDG Night Enzyme, should have translated the product information properly before they launched this supplement onto the West. Had this happened, we may have had a more positive opinion about it but overall, we do not recommend ISDG Night Enzyme to the Watchdog readers.

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ISDG Night Enzyme Key Features

ISDG Night Enzyme is a supplement which contains natural enzymes derived from 232 fruits and vegetables plus four amino acids, and according to the product information, is a formula that will help you shape your body, improve immunity, and help weight loss while you sleep.

Enzymes are biological molecules that speed up chemical reactions in the body, and are present throughout all living things. The word “enzyme” sounds scientific but of course, the truth is that enzymes are everywhere. The body makes digestive enzymes and we also obtain them by diet.

The different digestive enzymes all have different roles; Protease helps break down protein, and Amalyse breaks down carbs for example. So the aim of this supplement is to deliver a range of digestive enzymes, in order to keep the digestion system functioning correctly. Source

ISDG Night Enzyme Facts

  • Japanese supplement and supplement company
  • Each package contains 120 pills or one month’s supply
  • On sale via Amazon USA

There are four ISDG supplements in the range. The basic 232 enzyme formula is the same for all of them, with the only difference being additional ingredients depending on the purpose. With ISDG Night Enzyme, it is four amino acids, although only three are actually named. These are L Lysine, Ornithine, and L Arginine. Ingredient quantities are unknown and the fourth amino acid is unnamed.

How to Take ISDG Night Enzyme

  • Take 4 pills daily with warm water before sleeping
  • Increasing your water intake and your exercise is beneficial while taking this supplement

Some of the problems with this supplement come down to a problem of translation. The product information on the packaging and the ingredients list is all in Japanese, so you only have the claims of the advertising to go on.

None of this tells you very much but with the colourful packaging and some graphs that mention benefits to health, some customers will find it attractive and interesting. The fact that the supplement is Japanese is appealing, but we just wish that the marketers had explained the product or at least provided an accurate ingredients list.

ISDG Night Enzyme Concerns:

  • Side effects or unforeseen allergic reactions could be an issue for some users
  • A guarantee is advertised but will it be easy to claim a refund if you are dissatisfied?
  • No information regarding manufacture or the quality of this supplement.
  • None of the customers reviewing this supplement appears to have English as their first language. Does this imply that these reviews have been written by the people selling this supplement?

It is important to remember that just because Japan is well known for medicine and health research, it does not mean that everything that comes out of Japan is good and high quality. We checked out the website, which to our eyes looked low quality and frantic despite a classy looking logo.

ISDG supplements are on sale via Amazon.

We covered iSDG enzyme pills in a previous review and, presumably, these are the day time version.

What Does ISDG Night Enzyme Claim To Do?

The product information explains the role of enzymes in the body,

“Enzyme is essential to life process. About 6,000 kinds of enzyme exist in our bodies which participate in daily vital activities like breath, heartbeat, digestion and absorption. Lack of enzyme may cause related health problems. Lack some kinds of enzyme may result in obese even someone eats little. So enzyme is important to our bodies.”

The key features are as follows:

  • Better Digestion
  • Improve Immunity
  • Decompose Fat
  • Anti-Fatigue
  • Body-Shaping
  • Weight-Loss
  • Accelerate-Metabolism

Bizarrely this supplement is aimed at “Obese people, adults, white-collar worker”.

According to the advertising, this supplement comes with a money-back guarantee.

“100% Guarantee: Weight loss and immunity improved or your money back!”

“Natural Ingredients: Fermented from 232 Natural Vegetables & Fruits, GLUTEN FREE & NON-GMO. Fat burner pills mainly for weight loss and body shaping during sleeping. Best to improve immunity, anti-fatigue and support a healthy mood.”

Does ISDG Night Enzyme Work?

The supplement is a complete unknown! The main bulk of the supplement – the Enzyme formula with the 232 different fruit and vegetable extracts may have an effect upon digestion, but there is no real evidence it will work as described. That said, it might help some people but it may also cause adverse side effects such as an upset stomach. The simple answer is that we just don’t know, and neither does anyone else! Effects will depend upon the ingredient quantities, your own physical makeup, and your existing diet and lifestyle.

The three named amino acids look more promising. L Ornithine, L Lysine, and L Arginine have undergone clinical tests, and results were positive in that the ingredients do seem to improve sleep patterns and reduce stress. The downside is that we have no way of knowing whether the contents in this supplement conform to this limited clinical testing.

What Are The Ingredients of ISDG Night Enzyme?

Serving size is equal to two pills. Ingredient quantities are not provided and although the product information claims that the supplement contains four amino acids, only three are named.

  • L Ornithine: L Ornithine is a non-essential non-protein amino acid contained in small amounts in various foods. Clinical testing in Japan suggests that L Ornithine may have the potential to relieve stress and improve sleep quality related to fatigue. Testing was carried out on small animals and then on a human trial of 55 participants. The conclusion of the study suggested that L-ornithine has a positive effect on stress and sleep in healthy workers. Source
  • L Arginine and L Lysine: These amino acids have been shown to reduce anxiety in humans who have a diet low in L Lysine (it is present in foodstuffs including cheese fish lentils). A human clinical trial carried out on 108 Japanese adults concluded that oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans. The serving size was 2.64 g of L Lysine and 2.64 g of L-arginine per day. However, the quantities contained in this supplement are unknown and seem unlikely to conform to this high serving size. Source

All the ISDG supplements contain the following formula:

  • Composite plant cultivated sugar [indigestible dextrin, sugar (brown sugar, oligosaccharide)
  • Fruits: Grape, peach, apple, oranges, oyster, ususe, kiwi, kumquat, lemon, blueberry, akebi, yamamomo, pear, banana, primson, pineapple, Yamaguchi, Yamagumi, Sudachi, Kabosu, avocado, tomatoes, strawberries, prunes, dutch strawberries, Ashiya, cam cam, acai, kuchananoshi, lime,
  • Wild vegetables: Perilla, radish, cane, tomato, cucumber, cabbage, tomato, cucumber, cabbage, egg, komatsuna, celery, spinach, chinensis, celery, spinach, chinensai, green pepper, bitter gourd, vitamin cream, pumpkin, carrots, burdock, broccoli, seri, misuba, milk, kel, barley young leaves, moroheiya, lotus root, turmeric, ginger, red meadow, turnip, onion, wasabi, mouth, potato, sweet potato, taro, garlic, Fukui, Mizuna, Chisha,
  • Salad, vegetables: Purple cabbage, sunny lettuce, Asatsuki, green onions, cauliflower, edible chrysanthemums, bamboo shoots, zuiki, odor, white chestnuts, sugi, stews, zucchini, okra, lettuce, chicory, cassava, red turnip, Yakon, Paulica, Red Onion, Kokumin, Fukuinoto, Tara Bud, Bracken, Lucky, Nano Hana, White Asparagus, Cherry Blossom, Pecoros, mustard sprout, alfalfa, beets, purimo, radish, hornwort,
  • Wild grasses: Psyllium, Kuwasaza, Legumina.

Does ISDG Night Enzyme Have Any Side Effects?

Potential side effects may include digestive issues such as:

  • Bloating
  • Gas
  • Abdominal discomfort
  • Diarrhoea
  • Constipation

With the high number of ingredients, many of them unknown to consumers in the West, there may be a risk of an allergic reaction.


Not suitable for individuals under 18. Avoid if you are pregnant or breast feeding. Do not take if you are prone to allergies. Discontinue use in the case of an allergic reaction such as swelling, hives, breathing problems or a high temperature and seek medical advice immediately.

Are There Any Customer Reviews For ISDG Night Enzyme?

There are a few customer reviews for ISDG Night Enzyme on Amazon USA. Although there are only a handful of reviews, they seem to be pretty genuine.

This customer had already heard of the supplement,

Good heath product for daily usage, at Asia Regions is a very Famous for diet control


Great product! Helped regulate digestion

This customer felt it helped sleep but was less impressed by the price,

Really good product, really make me sleep deep and longer. But why price increase that much?

This customer felt it caused constipation,

Good enzyme if you don’t have any other options. I think it caused constipation and I really ended up sending mine back.

It is important to note that none of the reviewers appears to have English as their first language. Does this imply that these reviews have been written by the people selling this supplement?

Does ISDG Night Enzyme Offer a Money-Back Guarantee?

According to the product advertising, there is a 100% money-back guarantee. However, there are no terms and conditions about how to claim your money back if you are dissatisfied. One customer review mentions returning the product, but we can’t guarantee that ISDG will give you a refund. The only thing you can do is to contact ISDG via Amazon as soon as possible and to see what they suggest.

Where Can I Buy ISDG Night Enzyme?

If you are based in the USA, the easiest way to buy iSDG Night Enzyme is via Amazon USA. It does not seem to be currently available on Amazon UK, although this may change in the future. Customers in Asia can purchase via Lazada.

How does ISDG Night Enzyme compare to Phentaslim?

Criteria ISDG Night Enzyme Comparison Phentaslim comparison
Clinically Proven Ingredients
Side Effect Free
Positive Customer Reviews
24/7 Support
Money-back Guarantee

ISDG Night Enzyme is a Japanese supplement that is now available to the American market. The problem with this supplement is that there is no real proof it will work as described, and it is impossible to see just what you are taking. In our opinion, the company behind ISDG Night Enzyme, should have translated the product information properly, provided contact details, and provided adequate ingredient information.

ISDG Night Enzyme

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Disclaimer: Our reviews and investigations are based on extensive research from the information publicly available to us and consumers at the time of first publishing the post. Information is based on our personal opinion and whilst we endeavour to ensure information is up-to-date, manufacturers do from time to time change their products and future research may disagree with our findings. If you feel any of the information is inaccurate, please contact us and we will review the information provided.

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