Updated May 20, 2019.
Published Aug 30, 2017.

Synadrene is a weight-loss product that is heavily inspired by a more famous predecessor called Synadrex (which was produced in various forms by a separate manufacturer). Both products live on the extreme boundaries of what is considered legal to sell in the unregulated supplement market, and both are essentially stimulant-mixes that provide weight-loss benefits at the expense of severe side effects and risks. Synadrene’s primary and most effective ingredient is DMAA, a risky stimulant that was banned by the FDA in 2013.


  • Product is likely to work broadly as advertised


  • Product is extremely expensive
  • Considered by many customers to be a poor-quality rip-off of Synadrex
  • Product contains banned ingredients and should cause a number of side effects
  • Ingredient quantities are unlisted
DMAA has a long and storied history within the supplement world. Although it is thought to be an effective weight-loss aid and energy booster, DMAA is chemically extremely similar to amphetamines and carries similar risks. It was effectively banned in 2013 by the FDA, after the agency received 86 reports of serious adverse effects (including strokes and seizures) and a military medical journal linked it to the deaths of 2 soldiers. Despite the ban, numerous companies still produce products with DMAA, and some are even fighting the authorities to argue for their right to sell the substance.

Below, we take an in-depth look into Synadrene, to see whether this DMAA-based product is safe enough to be considered by dieters.

Synadrene Overview

What you need to know about Synadrene

Synadrene is manufactured by Hi-Tech Pharmaceuticals, a US-based supplement store based in the USA. Hi-Tech Pharma (as they are often called) are known mainly for their extraordinary history of litigation, having fought long and protracted legal battles with the FTC, FDA, respected university professors, medical authorities and rival companies. The company is currently fighting to overturn the FDA’s existing ban on the dangerous stimulant DMAA, on the basis that it can be naturally derived from plants. Until this legal point is clarified, Hi-Tech Pharma continue to defiantly sell DMAA-based products, as well as products that contain senegalia berlandieri (a natural source of otherwise banned substances like methylsynephrine).

What are the side effects of Synadrene?

Synadrene contains substances that were banned for a reason, and thus may come with serious side effects. These effects are too numerous to list here, but readers can check out the Side Effects tab to read more if desired.

The most notable cause of side effects in Synadrene is DMAA, which causes increased blood pressure and heart rate. DMAA was directly found to cause strokes, heart attacks and death before it was banned. Other side effects may include shortness of breath and tightening in the chest, seizures, neurological problems and psychiatric problems. This mix also contains caffeine, which can cause numerous issues (such as insomnia and jitters) in customers who are sensitive to it.

For reasons unknown, Synadrene contains massive doses of certain vitamins and minerals. Such huge doses could cause serious side effects over time, including brain and nerve problems, liver and kidney damage, stomach ulcers, muscle damage, blood disorders, headaches, and other minor side effects. Synadrene’s own caution box recommends that customers avoid taking the product for more than 8 weeks.

How much does Synadrene cost?

From most online suppliers (including My Supplement Store, Best Price Nutrition, and Same Day Supplements), a 2-week supply of Synadrene with 45 capsules costs $34.95. The price is significantly higher on the Hi-Tech Pharma webstore, reaching a bafflingly high price of $69.95 – that’s $140 for a month’s supply.

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Synadrene Key Features

Synadrene is a weight-loss aid that uses the banned ingredient, DMAA. The product is based on and heavily influenced by a now discontinued and illegal formula called Synadrex, which was produced by controversial manufacturer USPLabs. Though not identical, Synadrene can be regarded as an unofficial clone of Synadrex in terms of its ingredients list and marketing spiel, with slight alterations made to keep the manufacturer on (or near to) the right side of the law.

Synadrene Key Points

  • Manufactured by Hi-Tech Pharmaceuticals
  • Contains 45 capsules per bottle
  • Weight-loss supplement

Synadrene is produced and sold by Hi-Tech Pharmaceuticals, an American manufacturer of various sports, weight-loss and sexual enhancement supplements. Hi-Tech Pharmaceuticals is far more well-known for its legal battles with American authorities and university professors than for its effective and high-quality supplements. As of 2017, its most high-profile legal fracas is being fought against the FDA over whether the company has the right to sell DMAA; although it is clearly banned, Hi-Tech Pharma appear to be continuing their policy of selling banned ingredients until they are forced not to. Despite such a bullish standing against the authorities, Hi-Tech Pharma do not appear to be a particularly major player in the industry, and their poorly-written website and lack of presence with major distributors like Amazon and Walmart give the appearance of an unprofessional small-fry. The company can be contacted via the contact details provided on the website.

How to Take Synadrene

Take 1 capsules three times daily. Do not exceed 4 capsules in any 24-hour period.

Synadrene Concerns:

  • Product is extraordinarily expensive
  • Ingredient quantities not listed
  • Product contains banned and dangerous ingredients

What does Synadrene claim to do?

On the official Hi-Tech Pharma website, very few claims are made about what Synadrene is supposed to do. The company writes at length about its “brave” fight against the FDA and its regulations, and brags about the product’s similarity to a now-banned original called Synadrex. It is presumed that most customers are already aware of the original product, and should thus know and assume what the effects of Synadrene will be.

On other seller websites, more specific benefits are described. Synadrene is intended to act as a weight-loss product, and should help customers to burn fat even when resting. The following benefits are listed on the Synadrene product page hosted on Best Price Nutrition:

  • Thermogenic fat burning
  • Boosts energy levels
  • Improved mood and focus
  • Stops hunger

Does Synadrene work?

This product contains DMAA, caffeine and green tea and should work well as a fat burner (albeit one that will come with a host of side effects). This ingredient combination should also give customers a significant energy boost. Alpha Lipoic Acid has a somewhat good reputation as an appetite suppressant, which should combine well with the DMAA to stave off hunger.

Overall, customers should expect the product to work as advertised, although most of the product’s remaining ingredients are strange to say the least. Synadrene is intended to act as a barely-disguised rip-off of a more famous product, and has thus made the same bizarre choices as its predecessor. To our knowledge, sandalwood, sulbutiamine, and poly-thyronine won’t do anything related to weight-loss and have apparently been included so as not to deviate too far from the original Synadrex formula.

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Synadrene Ingredients

The ingredients contained within Synadrene are listed below. Readers should note that the individual ingredient quantities are not listed, which can make it difficult for us to estimate how effective the product is. Those that are listed are correct for 1 capsule of Synadrene.

  • Vitamin B12 (as Cyanocobalamin) 100mcg: Vitamin B12 is naturally present in many foods, primarily meat, fish and dairy products. It has several roles, including aiding in releasing energy from consumed food, and keeping the nervous system healthy. It may be that a deficiency hinders weight loss, but taking excess amounts could be, according to the NHS, potentially harmful. This dose of vitamin B12 is actually huge; customers taking the manufacturer’s recommended dosage of Synadrene will end up receiving 5000% of their RDA for vitamin B12.
  • Vitamin B3 (as Niacin) 20mg: Vitamin B3, or Niacin, is responsible for helping to produce energy from consumed food, as well as helping keep the nervous and digestive systems healthy. Niacin can be easily sourced in adequate amounts from a balanced diet. Customers taking the manufacturer’s recommended dosage of Synadrene will end up receiving 300% of their RDA for vitamin B3.
  • Chromium (from Chromium Polynicotinate) 175mcg: This is used primarily to lower fasting blood sugar levels and to lower insulin levels in people who have type 2 diabetes. In terms of its potential effect upon weight loss, it is possible that taking chromium picolinate by mouth for 2 to 3 months might produce a small weight loss of about 1.1 kg. This is obviously an incredibly small amount of weight loss, but studies are still inconclusive. Customers taking the manufacturer’s recommended dosage of Synadrene will end up receiving 435% of their RDA for chromium.
  • Vitamin B6 (as pyridoxine HCI) 4.25mg: Vitamin B6 has several important functions in the body, including ‘allowing the body to use and store energy from protein and carbohydrates in food’. Whilst taking excess amounts of vitamin B6 will not infinitely improve this ability, a deficiency could make it more difficult to lose weight. Vitamin B6 is naturally present in a wide variety of foods, including meat, cereals, bread and vegetables, and is often included in fortified breakfast cereals. Customers taking the manufacturer’s recommended dosage of Synadrene will end up receiving 636% of their RDA for vitamin B12.

Synadrene Proprietary Blend 815mg

  • Methylxanthine: This class of drugs is typically used to treat respiratory problems like asthma. It is also the class of drug to which caffeine belongs, so customers can expect this ingredient choice to work in much the same way as caffeine.
  • Green Tea Extract (leaves): Green tea is high in a group of antioxidants called catechins. Studies have suggested that catechins increase thermogenesis in the body, whilst caffeine increases energy expenditure by boosting the metabolism slightly for few hours.
  • 1,3-Dimethylamylamine HCI: More commonly referred to as DMAA, this lab-created ingredient appears to be derived from amphetamines. It acts as a stimulant, increasing energy levels, and aiding weight loss, but there is a lack of human studies into how it works and how effective it is at aiding weight loss- the majority of its support comes from anecdotal reports from consumers. Once hugely popular, especially amongst bodybuilders and consumers of extremely strong diet pills, it has become much more difficult to source as the FDA has made continued efforts to remove it from the market and banning its distribution, with millions of dollars’ worth of supplements destroyed by numerous companies. As we discuss in more detail in the side effects section, it causes a wide variety of unpleasant and dangerous side effects.
  • Sulbutiamine: A synthetic molecule that consists of two thiamine molecules bound together chemically. It is thought that Sulbutiamine can treat fatigue, although evidence is still preliminary.
  • Sandalwood Extract: Hi-Tech Pharma fail to disclose whether they use red or white sandalwood (the two types are completely different). As it would be slightly more useful, we guess that this product contains red sandalwood, which can cause the body to lose water weight through causing it to more frequently urinate.
  • Yohimbine Extract: Some studies have noticed increased blood concentrations of free fatty acids in participants who use yohimbine extract, suggesting increased rates of lipolysis. However, the Natural Medicines Comprehensive Database has stated that there is insufficient evidence to claim it aids in weight loss.
  • Alpha Lipoic Acid: Appears to suppress the appetite by inhibiting AMPK in the hypothalamus although little research has been conducted in humans at this point. This fatty acid also appears to boost fat burning slightly, although the effects are not as large as the noted suppression of appetite.
  • Poly-Thyronine: There is very little information available about Poly-Thyronine. It apparently stimulates the thyroid, which could then stimulate the body’s metabolic rate, but there is no clinical evidence available to support this claim.

Synadrene Side Effects

Synadrene is a stimulant-based weight-loss product, and is therefore very likely to come with side effects that many will find unpleasant.

DMAA is a banned substance for a reason. 1, 3-Dimethylamylamine significantly increases blood pressure and heart rate, and has been linked with causing strokes, heart attacks and death, even in previously healthy people. Other side effects may include shortness of breath and tightening in the chest, seizures, neurological problems and psychiatric problems. The FDA has been engaged in a major campaign to remove it entirely from the unregulated supplement market for many years, a motion that is heavily resisted by a few unscrupulous companies like Hi-Tech Pharma.

Side effects of caffeine can include headaches, increased heart rate, increased blood pressure, heart palpitations, increased urination, dehydration, jitteriness, dizziness and insomnia. Yohimbe can also cause a wide range of side effects, including stomach upset, excitation, tremor, sleep problems, anxiety or agitation, high blood pressure, a racing heartbeat, dizziness, stomach problems, drooling, sinus pain, irritability, headache, frequent urination, bloating, rash, nausea, and vomiting. High doses can cause more severe effects.

Synadrene also contains huge doses of certain vitamins and minerals – although these ingredients are not often harmful, such massive quantities can cause issues over time. In large doses, chromium can on rare occasions cause skin irritation, headaches, nausea, dizziness, mood changes and impaired coordination and thinking. High doses have also been linked to liver damage, kidney damage and blood disorders. Vitamin B3 sometimes causes flushing, stomach issues and diarrhoea, but on very rare occasions can also cause liver problems, stomach ulcers, muscle damage and blood pressure/heart rhythm issues. Long-term high doses of Vitamin B6 have been linked with brain and nerve problems, and can also cause vomiting, loss of appetite, headaches, tingling and sleepiness.


Not for use by individuals under the age of 18 years. Do not use if you are pregnant or nursing. This product can raise blood pressure and interfere with other drugs you may be taking. Talk to your doctor about this product. Individuals who consume caffeine with this product may experience serious adverse health effects. Individuals who are sensitive to the effects of caffeine should consult a licensed health care professional before consuming this product. Do not consume synephrine or caffeine from other sources, including but not limited to, coffee, tea, soda or other dietary products or medications containing caffeine or phenylephrine. Do not use for more than 8 weeks. Consult with your physician prior to use if you are taking medication, including but not limited to MAOI inhibitors, aspirin, antidepressants, nonsteroidal anti-inflammatory drugs or products containing phylephrine, ephedrine, pseudoephedrine, or other stimulants. Consult your physician prior to use if you have a medical condition, including but not limited to, heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma. Discontinue 2 weeks prior to surgery or if you experience rapid heartbeat, dizziness, severe headaches or shortness of breath. In case of accidental overdose, seek professional assistance or contact a poison control center immediately. Avoid alcohol while taking this product. Exceeding recommended serving may cause serious adverse health effects, including heart attack and stroke. Improper use of this product may be hazardous to a person’s health.

Synadrene Customer Feedback

Synadrene is often compared to Synadrex in customer reviews for obvious reasons. It seems to hold up surprisingly poorly compared to the original; even fans of this product generally admit that it weaker than the original, with many citing serious side effects as the main drawback. Positive reviews still maintain that the product is effective enough to warrant consideration.

When Synedrex stopped being sold, I decided to try this. Killer product. The dmaa is awesome. I won’t ever use another fat burner without it in it. Try this and you won’t need anything else

I lost a lot of weight using synedrex. I would only need one a day. With Synedrene I need more to get the same affect. It does provide, mental clarity and decreased appetite. The energy levels aren’t off the chart like with synedrex. I will continue with Synedrene, it’s better than coffee of any other supplement that I’ve tried.

I was a huge fan of Synedrex, but something about Synedrene did not mesh well with me. Maybe it was something only with me, but I figured I’d write this review. I have taken this now on 2 separate occasions. The first time I took this in a stack with hydravax over a period of about 2 weeks. I definitely lost weight, but the side effects…

I’ve ordered a bottle of this hoping to give me the same energy boost as Synedrex before a workout. I’ve tried it for a week, one dose in the morning, I always end up with nausea and vomiting during my workout. I stopped using it. Not pleased to say the least.

Synadrene Money-Back Guarantee

On the official Hi-Tech Pharmaceuticals website, no mention is made of a money-back guarantee or a returns policy of any kind.

Where To Buy Synadrene

Synadrene is available to buy from a few specialist supplement retailers operating online, including the official Hi-Tech Pharma webstore, My Supplement Store, Best Price Nutrition, Same Day Supplements, A1 Supplements and more. It is not available to buy from more mainstream retailers like Amazon and Walmart due to its use of banned ingredients.

On most online webstores, a 2-week supply of Synadrene (45 capsules) costs $34.95. The price is significantly higher on the Hi-Tech Pharma webstore, reaching a colossal $69.95.

Watchdog Verdict

Synadrene is ultimately a very poor choice for dieters. Although it should work roughly as advertised, a significant number of customer reviews claim that the product is a poor version of the original it copies from (Synadrex), containing more side effects alongside fewer benefits. This is hard to believe, as the formula stays true to the original Synadrex product devoutly, even including the same useless ingredients as the original (such as bizarre choices like sandalwood).

The real reason to avoid this product is that it is ultimately illegal. Hi-Tech Pharma have continued their longstanding policy to fight the USA’s consumer protection and safety laws at every turn, and have infused this product with the banned stimulant, DMAA. Expect serious side effects from using this product, as well as the potential to cause the body serious damage if used for more than 8 weeks.

Hi-Tech Pharma are also shady in the extreme in virtually every other way. The company never publishes their ingredient quantities, fails to offer customers a returns policy, and prices their products ridiculously on their official webstore (this unimpressive weight-loss aid costs nearly $140 for a one month supply). Do your wallet and your body a favour and stay well away from Synadrene!

We do not recommend Synadrene to our readers.

How does Synadrene compare to Phentaslim?

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Disclaimer: Our reviews and investigations are based on extensive research from the information publicly available to us and consumers at the time of first publishing the post. Information is based on our personal opinion and whilst we endeavour to ensure information is up-to-date, manufacturers do from time to time change their products and future research may disagree with our findings. If you feel any of the information is inaccurate, please contact us and we will review the information provided.

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