Below we take an in-depth look into Synadrene, to see whether this DMAA-based product is safe enough to be considered by dieters.
Synadrene is a weight-loss product that is heavily inspired by a more famous predecessor called Synadrex (which was produced in various forms by a separate manufacturer). Both products live on the extreme boundaries of what is considered legal to sell in the unregulated supplement market, and both are essentially stimulant-mixes that provide weight-loss benefits at the expense of severe side effects and risks. Synadrene’s primary and most effective ingredient is DMAA, a risky stimulant that was banned by the FDA in 2013.
Synadrene is manufactured by Hi-Tech Pharmaceuticals, a US-based supplement store based in the USA. Hi-Tech Pharma (as they are often called) are known mainly for their extraordinary history of litigation, having fought long and protracted legal battles with the FTC, FDA, respected university professors, medical authorities and rival companies. The company is currently fighting to overturn the FDA’s existing ban on the dangerous stimulant DMAA, on the basis that it can be naturally derived from plants. Until this legal point is clarified, Hi-Tech Pharma continue to defiantly sell DMAA-based products, as well as products that contain senegalia berlandieri (a natural source of otherwise banned substances like methylsynephrine).
Synadrene contains substances that were banned for a reason, and thus may come with serious side effects. These effects are too numerous to list here, but readers can check out the Side Effects tab to read more if desired.
The most notable cause of side effects in Synadrene is DMAA, which causes increased blood pressure and heart rate. DMAA was directly found to cause strokes, heart attacks and death before it was banned. Other side effects may include shortness of breath and tightening in the chest, seizures, neurological problems and psychiatric problems. This mix also contains caffeine, which can cause numerous issues (such as insomnia and jitters) in customers who are sensitive to it.
For reasons unknown, Synadrene contains massive doses of certain vitamins and minerals. Such huge doses could cause serious side effects over time, including brain and nerve problems, liver and kidney damage, stomach ulcers, muscle damage, blood disorders, headaches, and other minor side effects. Synadrene’s own caution box recommends that customers avoid taking the product for more than 8 weeks.
From most online suppliers (including My Supplement Store, Best Price Nutrition, and Same Day Supplements), a 2-week supply of Synadrene with 45 capsules costs $34.95. The price is significantly higher on the Hi-Tech Pharma webstore, reaching a bafflingly high price of $69.95 – that’s $140 for a month’s supply.
Synadrene is ultimately a very poor choice for dieters. Although it should work roughly as advertised, a significant number of customer reviews claim that the product is a poor version of the original it copies from (Synadrex), containing more side effects alongside fewer benefits. This is hard to believe, as the formula stays true to the original Synadrex product devoutly, even including the same useless ingredients as the original (such as bizarre choices like sandalwood).
The real reason to avoid this product is that it is ultimately illegal. Hi-Tech Pharma have continued their longstanding policy to fight the USA’s consumer protection and safety laws at every turn, and have infused this product with the banned stimulant, DMAA. Expect serious side effects from using this product, as well as the potential to cause the body serious damage if used for more than 8 weeks.
Hi-Tech Pharma are also shady in the extreme in virtually every other way. The company never publishes their ingredient quantities, fails to offer customers a returns policy, and prices their products ridiculously on their official webstore (this unimpressive weight-loss aid costs nearly $140 for a one month supply). Do your wallet and your body a favour and stay well away from Synadrene!
We do not recommend Synadrene to our readers.
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Synadrene is a weight-loss aid that uses the banned ingredient, DMAA. The product is based on and heavily influenced by a now discontinued and illegal formula called Synadrex, which was produced by controversial manufacturer USPLabs. Though not identical, Synadrene can be regarded as an unofficial clone of Synadrex in terms of its ingredients list and marketing spiel, with slight alterations made to keep the manufacturer on (or near to) the right side of the law.
Synadrene is produced and sold by Hi-Tech Pharmaceuticals, an American manufacturer of various sports, weight-loss and sexual enhancement supplements. Hi-Tech Pharmaceuticals is far more well-known for its legal battles with American authorities and university professors than for its effective and high-quality supplements. As of 2017, its most high-profile legal fracas is being fought against the FDA over whether the company has the right to sell DMAA; although it is clearly banned, Hi-Tech Pharma appear to be continuing their policy of selling banned ingredients until they are forced not to. Despite such a bullish standing against the authorities, Hi-Tech Pharma do not appear to be a particularly major player in the industry, and their poorly-written website and lack of presence with major distributors like Amazon and Walmart give the appearance of an unprofessional small-fry. The company can be contacted via the contact details provided on the website.
The directions for use are as follows:
Take 1 capsules three times daily. Do not exceed 4 capsules in any 24-hour period.
On the official Hi-Tech Pharma website, very few claims are made about what Synadrene is supposed to do. The company writes at length about its “brave” fight against the FDA and its regulations, and brags about the product’s similarity to a now-banned original called Synadrex. It is presumed that most customers are already aware of the original product, and should thus know and assume what the effects of Synadrene will be.
On other seller websites, more specific benefits are described. Synadrene is intended to act as a weight-loss product, and should help customers to burn fat even when resting. The following benefits are listed on the Synadrene product page hosted on Best Price Nutrition:
This product contains DMAA, caffeine and green tea and should work well as a fat burner (albeit one that will come with a host of side effects). This ingredient combination should also give customers a significant energy boost. Alpha Lipoic Acid has a somewhat good reputation as an appetite suppressant, which should combine well with the DMAA to stave off hunger.
Overall, customers should expect the product to work as advertised, although most of the product’s remaining ingredients are strange to say the least. Synadrene is intended to act as a barely-disguised rip-off of a more famous product, and has thus made the same bizarre choices as its predecessor. To our knowledge, sandalwood, sulbutiamine, and poly-thyronine won’t do anything related to weight-loss and have apparently been included so as not to deviate too far from the original Synadrex formula.
The ingredients contained within Synadrene are listed below. Readers should note that the individual ingredient quantities are not listed, which can make it difficult for us to estimate how effective the product is. Those that are listed are correct for 1 capsule of Synadrene.
Synadrene Proprietary Blend 815mg
Synadrene is a stimulant-based weight-loss product, and is therefore very likely to come with side effects that many will find unpleasant.
DMAA is a banned substance for a reason. 1, 3-Dimethylamylamine significantly increases blood pressure and heart rate, and has been linked with causing strokes, heart attacks and death, even in previously healthy people. Other side effects may include shortness of breath and tightening in the chest, seizures, neurological problems and psychiatric problems. The FDA has been engaged in a major campaign to remove it entirely from the unregulated supplement market for many years, a motion that is heavily resisted by a few unscrupulous companies like Hi-Tech Pharma.
Side effects of caffeine can include headaches, increased heart rate, increased blood pressure, heart palpitations, increased urination, dehydration, jitteriness, dizziness and insomnia. Yohimbe can also cause a wide range of side effects, including stomach upset, excitation, tremor, sleep problems, anxiety or agitation, high blood pressure, a racing heartbeat, dizziness, stomach problems, drooling, sinus pain, irritability, headache, frequent urination, bloating, rash, nausea, and vomiting. High doses can cause more severe effects.
Synadrene also contains huge doses of certain vitamins and minerals – although these ingredients are not often harmful, such massive quantities can cause issues over time. In large doses, chromium can on rare occasions cause skin irritation, headaches, nausea, dizziness, mood changes and impaired coordination and thinking. High doses have also been linked to liver damage, kidney damage and blood disorders. Vitamin B3 sometimes causes flushing, stomach issues and diarrhoea, but on very rare occasions can also cause liver problems, stomach ulcers, muscle damage and blood pressure/heart rhythm issues. Long-term high doses of Vitamin B6 have been linked with brain and nerve problems, and can also cause vomiting, loss of appetite, headaches, tingling and sleepiness.
Not for use by individuals under the age of 18 years. Do not use if you are pregnant or nursing. This product can raise blood pressure and interfere with other drugs you may be taking. Talk to your doctor about this product. Individuals who consume caffeine with this product may experience serious adverse health effects. Individuals who are sensitive to the effects of caffeine should consult a licensed health care professional before consuming this product. Do not consume synephrine or caffeine from other sources, including but not limited to, coffee, tea, soda or other dietary products or medications containing caffeine or phenylephrine. Do not use for more than 8 weeks. Consult with your physician prior to use if you are taking medication, including but not limited to MAOI inhibitors, aspirin, antidepressants, nonsteroidal anti-inflammatory drugs or products containing phylephrine, ephedrine, pseudoephedrine, or other stimulants. Consult your physician prior to use if you have a medical condition, including but not limited to, heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma. Discontinue 2 weeks prior to surgery or if you experience rapid heartbeat, dizziness, severe headaches or shortness of breath. In case of accidental overdose, seek professional assistance or contact a poison control center immediately. Avoid alcohol while taking this product. Exceeding recommended serving may cause serious adverse health effects, including heart attack and stroke. Improper use of this product may be hazardous to a person’s health.
Synadrene is often compared to Synadrex in customer reviews for obvious reasons. It seems to hold up surprisingly poorly compared to the original; even fans of this product generally admit that it weaker than the original, with many citing serious side effects as the main drawback. Positive reviews still maintain that the product is effective enough to warrant consideration.
When Synedrex stopped being sold, I decided to try this. Killer product. The dmaa is awesome. I won’t ever use another fat burner without it in it. Try this and you won’t need anything else
I lost a lot of weight using synedrex. I would only need one a day. With Synedrene I need more to get the same affect. It does provide, mental clarity and decreased appetite. The energy levels aren’t off the chart like with synedrex. I will continue with Synedrene, it’s better than coffee of any other supplement that I’ve tried.
I was a huge fan of Synedrex, but something about Synedrene did not mesh well with me. Maybe it was something only with me, but I figured I’d write this review. I have taken this now on 2 separate occasions. The first time I took this in a stack with hydravax over a period of about 2 weeks. I definitely lost weight, but the side effects…
I’ve ordered a bottle of this hoping to give me the same energy boost as Synedrex before a workout. I’ve tried it for a week, one dose in the morning, I always end up with nausea and vomiting during my workout. I stopped using it. Not pleased to say the least.
On the official Hi-Tech Pharmaceuticals website, no mention is made of a money-back guarantee or a returns policy of any kind.
Synadrene is available to buy from a few specialist supplement retailers operating online, including the official Hi-Tech Pharma webstore, My Supplement Store, Best Price Nutrition, Same Day Supplements, A1 Supplements and more. It is not available to buy from more mainstream retailers like Amazon and Walmart due to its use of banned ingredients.
On most online webstores, a 2-week supply of Synadrene (45 capsules) costs $34.95. The price is significantly higher on the Hi-Tech Pharma webstore, reaching a colossal $69.95.
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Disclaimer: Our reviews and investigations are based on extensive research from the information publicly available to us and consumers at the time of first publishing the post. Information is based on our personal opinion and whilst we endeavour to ensure information is up-to-date, manufacturers do from time to time change their products and future research may disagree with our findings. If you feel any of the information is inaccurate, please contact us and we will review the information provided.